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Database: UniProt
Entry: G7P5T2_MACFA
LinkDB: G7P5T2_MACFA
Original site: G7P5T2_MACFA 
ID   G7P5T2_MACFA            Unreviewed;      1356 AA.
AC   G7P5T2;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   05-JUN-2019, entry version 47.
DE   SubName: Full=Vascular endothelial growth factor receptor 2 {ECO:0000313|EMBL:EHH53800.1};
GN   ORFNames=EGM_14501 {ECO:0000313|EMBL:EHH53800.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
RN   [1] {ECO:0000313|EMBL:EHH53800.1, ECO:0000313|Proteomes:UP000009130}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CE-4 {ECO:0000313|EMBL:EHH53800.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
RA   Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
RA   Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
RA   Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
RA   Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
RA   Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
RA   Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal
RT   models, the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-
CC         tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000256|RuleBase:RU000311,
CC         ECO:0000256|SAAS:SAAS01176171};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU000311};
CC       Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU000311}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. CSF-1/PDGF receptor subfamily.
CC       {ECO:0000256|RuleBase:RU000311}.
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DR   EMBL; CM001280; EHH53800.1; -; Genomic_DNA.
DR   STRING; 9541.XP_005555327.1; -.
DR   Proteomes; UP000009130; Chromosome 5.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019838; F:growth factor binding; IEA:InterPro.
DR   GO; GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IEA:InterPro.
DR   GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 7.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013151; Immunoglobulin.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR001824; Tyr_kinase_rcpt_3_CS.
DR   InterPro; IPR041348; VEGFR-2_TMD.
DR   InterPro; IPR009136; VEGFR2_rcpt.
DR   PANTHER; PTHR24416:SF45; PTHR24416:SF45; 1.
DR   Pfam; PF07679; I-set; 2.
DR   Pfam; PF00047; ig; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF17988; VEGFR-2_TMD; 1.
DR   PRINTS; PR01834; VEGFRECEPTR2.
DR   SMART; SM00409; IG; 7.
DR   SMART; SM00408; IGc2; 5.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF48726; SSF48726; 6.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50835; IG_LIKE; 5.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS00240; RECEPTOR_TYR_KIN_III; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00600564};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009130};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00916669};
KW   Immunoglobulin domain {ECO:0000256|RuleBase:RU000311,
KW   ECO:0000256|SAAS:SAAS00290237};
KW   Kinase {ECO:0000256|SAAS:SAAS00601152};
KW   Membrane {ECO:0000256|SAAS:SAAS00602125, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00600689};
KW   Receptor {ECO:0000256|RuleBase:RU000311,
KW   ECO:0000256|SAAS:SAAS00600436, ECO:0000313|EMBL:EHH53800.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009130};
KW   Repeat {ECO:0000256|SAAS:SAAS00295312};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS00601608};
KW   Transmembrane {ECO:0000256|RuleBase:RU000311,
KW   ECO:0000256|SAAS:SAAS00600943, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00602683,
KW   ECO:0000256|SAM:Phobius};
KW   Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00582553}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20   1356       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003502079.
FT   TRANSMEM    765    786       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      224    320       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      328    414       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      421    548       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      551    660       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      667    739       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      834   1162       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
FT   REGION     1283   1318       Disordered. {ECO:0000256|MobiDB-lite:
FT                                G7P5T2}.
FT   COMPBIAS   1283   1315       Polar. {ECO:0000256|MobiDB-lite:G7P5T2}.
SQ   SEQUENCE   1356 AA;  151494 MW;  8C4FF849B5DF82B5 CRC64;
     MASKVLLAVA LWLCVETRAA SVGLPSVSLD LPRLSIQKDI LTIKANTTLQ ITCRGQRDLD
     WLWPNNQSGS EQRVEVTECS DGLFCKTLTI PKVIGNDTGA YKCFYRETDL ASVIYVYVQD
     YRSPFIASVS DQHGVVYITE NKNKTVVIPC LGSISNLNVS LCARYPEKRF VPDGNRISWD
     SKKGFTIPSY MISYAGMVFC EAKINDESYQ SIMYIVVVVG YRIYDVVLSP SHGVELSVGE
     KLVLNCTART ELNVGIDFNW EYPSSKHQHK KLVNRDLKTQ SGSEMKKFLS TLTIDGVTRS
     DQGLYTCAAS SGLMTKKNST FVRVHEKPFV AFGSGMESLV EATLGERVRI PVKYLGYPPP
     EIKWYKNGIP LESNHTVKVG HVLTIMEVSE RDTGNYTVIL TNPISKEKQS HVVSLVVYVP
     PQIGEKSLIS PVDSYQYGTT QTLTCTVYAI PPPHHIHWYW QLEEECPNEP SQAVSVTNPY
     PCEEWRSVED FQGGNKIEVN KNQFALIEGK NKTVSTLVIQ AANVSALYKC EAVNKVGRGE
     RVISFHVTRG PEITLQPDLQ PTEQESVSLW CTADKSTFEN LTWYKLGPQP LPVHVGELPT
     PVCKNLDTLW KLNATIFSNS TNDILIMELK NASLQDQGDY VCVAQDRKTK KRHCVVRQLT
     VLERVAPMIT GNLENQTTSI GETIEVSCTA SGNPPPQIMW FKDNETLVED SGIVLKDGNR
     NLTIRRVRKE DEGLYTCQAC SVLGCAKVEA FFIIEGAQEK TNLEIIILVG TAVIAMFFWL
     LLVIILRTVK RANGGELKTG YLSIVMDPDE LPLDEHCERL PYDASKWEFP RDRLKLGKPL
     GRGAFGQVIE ADAFGIDKTA TCRTVAVKML KEGATHSEHR ALMSELKILI HIGHHLNVVN
     LLGACTKPGG PLMVIVEFCK FGNLSTYLRS KRNEFVPYKT KGARFRQGKD YVGAIPVDLK
     RRLDSITSSQ SSASSGFVEE KSLSDVEEEE APEDLYKDFL TLEHLICYSF QVAKGMEFLA
     SRKCIHRDLA ARNILLSEKN VVKICDFGLA RDIYKDPDYV RKGDARLPLK WMAPETIFDR
     VYTIQSDVWS FGVLLWEIFS LGASPYPGVK IDEEFCRRLK EGTRMRAPDY TTPEMYQTML
     DCWHGEPSQR PTFSELVEHL GNLLQANAQQ DGKDYIVLPI SETLSMEEDS GLSLPTSPVS
     CMEEEEVCDP KFHYDNTAGI SQYLQNSKRK SRPVSVKTFE DIPLEEPEVK VIPDDNQTDS
     GMVLASEELK TLEDRTKLAP SFSGMVSSKS RESVASEGSN QTSGYQSGYH SDDTDTTVYS
     SEEAELLKLI EIGVQTGSTA QILQPDSGTT LSSPPV
//
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