ID G7P5X3_MACFA Unreviewed; 1221 AA.
AC G7P5X3;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Multimerin-1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=EGM_14545 {ECO:0000313|EMBL:EHH53841.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH53841.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH53841.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CM001280; EHH53841.1; -; Genomic_DNA.
DR AlphaFoldDB; G7P5X3; -.
DR eggNOG; ENOG502QTYP; Eukaryota.
DR Proteomes; UP000009130; Chromosome 5.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048583; P:regulation of response to stimulus; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15427; EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER; 1.
DR PANTHER; PTHR15427:SF3; MULTIMERIN-1; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07546; EMI; 1.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SMART; SM00181; EGF; 1.
DR SMART; SM00179; EGF_CA; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS50871; C1Q; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1221
FT /note="Multimerin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003502090"
FT DOMAIN 201..276
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 1034..1070
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1089..1221
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 71..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1060..1069
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1221 AA; 137954 MW; 36E6E72EB69933CC CRC64;
MKGARLFVLL SSLWSGGIGL NNSKHSWTIP EDGHSQKTMT SASVPPNKIQ SLQILPTTWV
MSAEIATAPE ARTSEESLLQ STLPPSETSA PAEGVRNQTP TSTERAEGVV KLQNLTLPTK
ANIEFNPGAE PVVLSNSTLK FLQSFARKSN EQATSLNAVG GVGGTGGVGN RAPRETYLSR
GDSSPSQRTD YQKSSFETTR GKNWCAYVHT RLSPTVILDN QVTYVPGGRG PCGWTGGSCP
QRSQKISNPI YRMQHKIVTS LDWRCCPGYS GPKCQLRAQE QQHLIHTNQA ESHTAVGRGV
AEQQQQDCGD PEVMRKMTDQ VNYQAKKLTL LQNKIDNISL TVNDIRNTYS SLEGKVNEDK
GREFQSLLKD LKSKSINVLV RDTVREQFKM FQNDMQDTVA QLFKTVSSLS EDLESTRQII
KKVNESVVSI AAQQKSVLMQ DDRPTLTDIV DLRNHIVNVR QEMTVTCEKP IKELEVKQTH
LEGALEQEHS RSILYYESLN KTLSQLKEVH EQLLSTEQVS DQKNVPAIES LSNNVTEYMS
TLHENMKKQS LMMLQLFEDL HIQESKINNL TISLEMEKES LRGECEDMLS KCRNDFKFQL
KDTEENLHVL NQTLAEVLFP MDNKMDQMSE QLNDLTYDME ILQPLLEQGA SLRQTMTYEQ
PKEAIVTRKK IENLTSAVNS LNFIIKELTK RHNLLRNEVQ SRDDTLERRI NEYALEMEDG
LNKTMTIVNN AIDFIQDNYA LKETLSTIKD NHEVHHKCTS DMETILTFIP QFQRLNDSIQ
ILINDNQRYN FVLQVAKTLA GIPRDEKLNQ SNFQKMFQMF NETTSQVRKY QQNMSHLEEK
MLLATKISKN LETRLQDIES KVTQTLIPYY ISLKKGNVVT NERDQALQLQ VLNSRFKALE
AKSIHLSSNF FLLNKTLHEV LTMCHNASTS VSELNATIPK WIKRSLPDIQ LLQKGLTEFV
EPIIQIKTQA VLSNLTCCID QSLPGSLANV VKSKKQVKSL PKKINMLKKP TVNLTTVLIG
RTQRNTDNVI YPEEYSSCSR HPCQNGGTCI NGRTSFTCAC RHPFTGDNCT IKLVEENALA
PDFSKGSYRY APMVAFFASH TYGMTTPGPI LFNNLDVNYG ASYTPRTGKF RIPYLGVYVF
KYTIESFSAH ISGFLVVDGI DKLAFESENI NSEIHCDRVL TGDALLELNY GQEVWLRLAK
GTIPAKFPPV TTFSGYLLYR T
//
