ID G7P7J0_MACFA Unreviewed; 561 AA.
AC G7P7J0; A0A2K5VZF5;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Neutral amino acid transporter 9 {ECO:0000256|ARBA:ARBA00040233};
DE AltName: Full=Solute carrier family 38 member 9 {ECO:0000256|ARBA:ARBA00042870};
GN Name=SLC38A9 {ECO:0000313|Ensembl:ENSMFAP00000030206.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000030206.1, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000030206.1, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000030206.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-asparagine(out) = L-asparagine(in); Xref=Rhea:RHEA:73423,
CC ChEBI:CHEBI:58048; Evidence={ECO:0000256|ARBA:ARBA00036663};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-glutamine(out) = L-glutamine(in); Xref=Rhea:RHEA:73419,
CC ChEBI:CHEBI:58359; Evidence={ECO:0000256|ARBA:ARBA00036878};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-leucine(in) = L-leucine(out); Xref=Rhea:RHEA:73011,
CC ChEBI:CHEBI:57427; Evidence={ECO:0000256|ARBA:ARBA00036887};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-tyrosine(in) = L-tyrosine(out); Xref=Rhea:RHEA:68572,
CC ChEBI:CHEBI:58315; Evidence={ECO:0000256|ARBA:ARBA00036984};
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC SLC38A9 subfamily. {ECO:0000256|ARBA:ARBA00038442}.
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DR RefSeq; XP_005556964.1; XM_005556907.2.
DR AlphaFoldDB; G7P7J0; -.
DR SMR; G7P7J0; -.
DR STRING; 9541.ENSMFAP00000030206; -.
DR Ensembl; ENSMFAT00000004411.2; ENSMFAP00000030206.1; ENSMFAG00000042280.2.
DR GeneID; 101866617; -.
DR KEGG; mcf:101866617; -.
DR CTD; 153129; -.
DR VEuPathDB; HostDB:ENSMFAG00000042280; -.
DR eggNOG; KOG1305; Eukaryota.
DR GeneTree; ENSGT00390000005646; -.
DR OrthoDB; 51748at2759; -.
DR Proteomes; UP000233100; Chromosome 6.
DR Bgee; ENSMFAG00000042280; Expressed in liver and 13 other cell types or tissues.
DR GO; GO:1990877; C:FNIP-folliculin RagC/D GAP; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0071986; C:Ragulator complex; IEA:Ensembl.
DR GO; GO:0015485; F:cholesterol binding; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR GO; GO:0061459; F:L-arginine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015182; F:L-asparagine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015186; F:L-glutamine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015190; F:L-leucine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032935; F:sterol sensor activity; IEA:Ensembl.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:Ensembl.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; IEA:Ensembl.
DR InterPro; IPR013057; AA_transpt_TM.
DR PANTHER; PTHR22950; AMINO ACID TRANSPORTER; 1.
DR PANTHER; PTHR22950:SF244; SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 9; 1.
DR Pfam; PF01490; Aa_trans; 2.
PE 3: Inferred from homology;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 119..239
FT /note="Amino acid transporter transmembrane"
FT /evidence="ECO:0000259|Pfam:PF01490"
FT DOMAIN 299..557
FT /note="Amino acid transporter transmembrane"
FT /evidence="ECO:0000259|Pfam:PF01490"
SQ SEQUENCE 561 AA; 63743 MW; 429633128354CDD9 CRC64;
MANMNSDSRH LGTSKVDHER DPGPMNIQFE PSDLRSKRPF YIEPTNIVNV NHVIQRVSDH
ASAMNKRIHY YSRLTTPADK ALIAPDHVVP GPEECYVYSP LGSAYKLQSY TEGYGKNTSL
VTIFMIWNTM MGTSILSIPW GIKQAGFTTG MCVIILMGLL TLYCCYRVVK SRTMISSLDT
TTWEYPDVCR HYFGSFGQWS SLLFSLVSLI GAMIVYWVLM SNFLFNTGKF IFNFIHHIND
TDTILSTNNS NPVICPSAGS GGHPDNSSMI FYANDTGAQQ FEKWWDKSRT VPFYLVGLLL
PLLNFKSPSF FSKFNILGTV SVLYLIFLVT FKAVRLGFHL EFHWFIPTEF FVPEIRFQFP
QLTGVLTLAF FIHNCIITLL KNNKKQENNV RDLCIAYMLV TLTYLYIGVL VFASFPSPPL
SKDCIEQNFL DNFPSSDTLS FIARIFLLFQ MMTVYPLLGY LARVQLLGHI FGDIYPSIFH
VLILNLIIVG AGVIMACFYP NIGGIIRYSG AACGLAFVFI YPSLIYIISL HQEERLTWPK
LVFHVFIIIL GVANLIVQFF M
//
