ID G7PCW8_MACFA Unreviewed; 469 AA.
AC G7PCW8;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=ADAM DEC1 {ECO:0000313|EMBL:EHH64054.1};
GN ORFNames=EGM_17173 {ECO:0000313|EMBL:EHH64054.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH64054.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH64054.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
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DR EMBL; CM001283; EHH64054.1; -; Genomic_DNA.
DR AlphaFoldDB; G7PCW8; -.
DR MEROPS; M12.219; -.
DR eggNOG; KOG3607; Eukaryota.
DR Proteomes; UP000009130; Chromosome 8.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR InterPro; IPR002870; Peptidase_M12B_N.
DR InterPro; IPR034027; Reprolysin_adamalysin.
DR PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR PANTHER; PTHR11905:SF125; ADAM DEC1; 1.
DR Pfam; PF01562; Pep_M12B_propep; 1.
DR Pfam; PF01421; Reprolysin; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00276};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..469
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003502180"
FT DOMAIN 218..412
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT DOMAIN 420..461
FT /note="Disintegrin"
FT /evidence="ECO:0000259|PROSITE:PS50214"
FT ACT_SITE 353
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT DISULFID 369..374
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
SQ SEQUENCE 469 AA; 52710 MW; 9F8EF03A7077C12A CRC64;
MLCGTSQLPA VATMSWVLLP VLWLIVQTQA IAIKQTPELT LHEIVRPIKL HILHKREIES
NQTEKHGKEE RYEPEVQYQM ILNGEEIILS LQKSKHLLGP DYTETLYSPR GEEITTKPEN
MEHCYYKGNI LNEKNSVASI STCHGLRGYF THHHQRYLIK PLKSTDEKEH AIFTSNQEEQ
DPANYTCGVR STGGKQGPIR ISRSLKSPEQ EDFLRAQKYI DLYLVLDNAF YKNYNENLTL
IRSFVFDVMN LLNVIYNTID VQVALVGMEI WSDGDKIKVV PSGSTTFNNF LRWHSSNLRE
KIHDHAQLLS GISFNNRRVG LAASNSLCSP SSIAVIEAKK KNSVALVAVM SHELGHVLGM
PDVPFDTKCP SGSCVMNQYL SSKFPKDFST SCRAHFERYL LSQKPKCLLQ APIPTNIMTT
PVCGNHLLEV GEDCDCGSPK ECTNLCCEAL KCKLKPGTDC GGDAPNHTT
//
