ID G7PDX6_MACFA Unreviewed; 1049 AA.
AC G7PDX6;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 08-NOV-2023, entry version 36.
DE RecName: Full=PKD domain-containing protein {ECO:0000259|PROSITE:PS50093};
DE Flags: Fragment;
GN ORFNames=EGM_18347 {ECO:0000313|EMBL:EHH65008.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH65008.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH65008.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR EMBL; CM001284; EHH65008.1; -; Genomic_DNA.
DR AlphaFoldDB; G7PDX6; -.
DR eggNOG; KOG3511; Eukaryota.
DR Proteomes; UP000009130; Chromosome 9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF10; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 953..971
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 687..731
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH65008.1"
FT NON_TER 1049
FT /evidence="ECO:0000313|EMBL:EHH65008.1"
SQ SEQUENCE 1049 AA; 117961 MW; 8BD369A56C1216B7 CRC64;
GGSAAEDLRL PSTSFALTGD SAHNQAMVHW SGHNSSVILI LTKLYDFNLG SVTESSLWRS
TDYGTTYEKL NDKVGLKTVL SYLYVNPTNK RKIMLLSDPE IESSILISSD EGATYQKYRL
TFYIQSLLFH PKQEDWVLAY SLDQKLYSSM DFGRRWQLMH ERITPNRFYW SVAGLDKEAD
LVHMEVRTTD GYAHYLTCRI QECAETTRNG PFARSIDISS LVVQDEYIFI QVTTGGRASY
YVSYRREAFA QIKLPKYSLP KDMHIISTDE NQVFAAVQEW NQNDTYNLYI SDTRGIYFTL
AMENIKSSRG LMGNIIIELY EVAGIKGIFL ANKKVDDQVK TYITYNKGRD WRLLQAPDVD
LRGSPVHCLL PFCSLHLHLQ LSENPYSSGR ISSKETAPGL VVATGNIGPE LSYTDIGVFI
SSDGGNTWRQ IFDEEYNVWF LDWGGALVAM KHTPLPVRHL WVSFDEGHSW DKYGFTSVPL
FVDGALVEAG METHIMTVFG HFSLRSEWQL VKVDYKSIFS RHCTKEDYQT WHLLNQGEPC
VMGERKIFKK RKPGAQCALG RDHSGSVVSE PCVCANWDFE CDYGYERHGE SQCVPAFWYN
PASPSKDCSL GQSYLNSTGY RRIVSNNCTD GLREKYTAKA QMCPGKAPRG LHVVTTDGRL
VAEQGHNATF IILMEEGDLQ RTNIQLDFGD GIAVSYANFS PIEDGIKHVY KSAGIFQVTA
YAENNLGSDT AVLFLHVVCP VEHVHLRVPF VAIRNKEVNI SAVVWPSQLG TLTYFWWFGN
STKPLITLDS SISFTFVAEG TNTITVQVAA GNALIQDTKE IAVHEYFQSQ LLSFSPNLDY
HNPDIPEWRQ DIGNVIKRAL VKVTSVPEDQ ILIAVFPGLP TSAELFILPP KNLTERRKGN
EGDLEQIVET LFNALNQNLV QFELKPGVQV IVYVTQLTLA PLVDSSAGHS SSAMLMLLSV
VFVGLAVFLI YKFKRKIPWI NIYAQVQHDK EQEMIGSVSQ SENAPKITLS DFTEPEELLD
KELDTRVIGG IATIANSEST KEIPNCTSV
//
