ID G7PEF6_MACFA Unreviewed; 1057 AA.
AC G7PEF6;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Integrin alpha-8 {ECO:0000313|EMBL:EHH64582.1};
DE Flags: Fragment;
GN ORFNames=EGM_17831 {ECO:0000313|EMBL:EHH64582.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH64582.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH64582.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; CM001284; EHH64582.1; -; Genomic_DNA.
DR AlphaFoldDB; G7PEF6; -.
DR eggNOG; KOG3637; Eukaryota.
DR Proteomes; UP000009130; Chromosome 9.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF5; INTEGRIN ALPHA-8; 1.
DR Pfam; PF01839; FG-GAP; 3.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 6.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 6.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 33..1057
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5001424826"
FT TRANSMEM 1006..1028
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 38..99
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 116..177
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 182..234
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 301..366
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 367..425
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 429..492
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 477..633
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 635..775
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 781..995
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH64582.1"
FT NON_TER 1057
FT /evidence="ECO:0000313|EMBL:EHH64582.1"
SQ SEQUENCE 1057 AA; 116971 MW; 452E6D1C14E05A39 CRC64;
RGPWGSRTPL IAPLCCAAAA LGMMMWSPAS QAFNLDVEKL TVYSGPEGSY FGYAVDFHIP
DARTASVLVG APKANTSQPD IVEGGAVYYC PWPAEGSAQC RQIPFDTTNN RKIRVNGTKE
HIEFKSNQWF GATVKAHKGK VVACAPLYHW RTLKPTPEKD PVGTCYVAIQ NFSAYAEFSP
CRNSNADPEG QGYCQAGFSL DFYKNGDLIV GGPGSFYWQG QVITASVADI IANYSFKDIL
RKLAGEKQTE VAPASYDDSY LGYSVAAGEF TGDSQQELVA GVPRGAQNFG YVSIINSTDM
TFIQNFTGEQ MASYFGYTIV VSDVNSDGLD DVLVGAPLFM EREFESNPRE VGQIYLYLQV
SSLLFRDPQI LTGTETFGRF GSAMAHLGDL NQDGYNDIAI GVPFAGKDQR GKVLIYNGNK
DGLNTKPSQV LQGVWASHAV PSGFGFTLRG DSDIDKNDYP DLIVGAFGTG KVAVYRARPV
VTVDAQLLLH PMIVNLENKT CQIPDSVTFA ACFSLRVCAS VAGQSISNTI VLMAEVQLDS
LKQKGAIKRT LFLDNHQAHH VFPLVIKGQK SHQCRDFIVY LRDEIEFRDK LSPINISLNY
SLDESTFKEG LEVKPILNYY RENVVSEQAH ILVDCGEDNL CVPDLKLSAR PDKHQVIIGD
ENHLMLIINA RNEGEGAYEA ELFVMIPEEA DYVGIERNNK GFRPLSCEYK MENVTRMVVC
DLGNPMVSGT NYSLGLRFAV PRLEKTNMSI NFDLQIRSSN KDNPDSNFVS LQINITAVAQ
VEIRGVSHPP QIVLPIHNWE PEEEPHKEEE VGPLVEHIYE LHNIGPSTIS DTILEVGWPF
SARDEFLLYI FHIQTLGPLQ CQTNPNINPQ DIKPAASPEH TPELSAFLRN STIPHLVRKR
DVPVVEFHRQ SPAKILNCTN IECLQISCAV GRLEGGESAV LKVRSRLWAH TFLQRKNDPY
ALASLVSFEV KKMPYKDQPA KLPEGSIAIK TSVIWATPNV SFSIPLWVII LAILLGLLVL
AILTLALWKC GFFDRARPPQ EDMTDKEQLT NDKTPEA
//
