ID G7PER4_MACFA Unreviewed; 415 AA.
AC G7PER4; A0A2K5UI59;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Heterogeneous nuclear ribonucleoprotein F {ECO:0000256|ARBA:ARBA00044148};
GN Name=HNRNPF {ECO:0000313|Ensembl:ENSMFAP00000012080.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000012080.1, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000012080.1, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000012080.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the heterogeneous nuclear ribonucleoprotein
CC (hnRNP) complexes which provide the substrate for the processing events
CC that pre-mRNAs undergo before becoming functional, translatable mRNAs
CC in the cytoplasm. Plays a role in the regulation of alternative
CC splicing events. Binds G-rich sequences in pre-mRNAs and keeps target
CC RNA in an unfolded state. {ECO:0000256|ARBA:ARBA00043862}.
CC -!- SUBUNIT: Identified in the spliceosome C complex. Interacts with AGO1,
CC AGO2, TBP and TXNL4/DIM1. {ECO:0000256|ARBA:ARBA00044002}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
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DR RefSeq; NP_001270670.1; NM_001283741.1.
DR RefSeq; XP_005565111.1; XM_005565054.2.
DR RefSeq; XP_005565112.1; XM_005565055.2.
DR RefSeq; XP_005565114.1; XM_005565057.2.
DR RefSeq; XP_005565115.1; XM_005565058.2.
DR RefSeq; XP_005565116.1; XM_005565059.2.
DR RefSeq; XP_005565117.1; XM_005565060.2.
DR RefSeq; XP_005565118.1; XM_005565061.2.
DR RefSeq; XP_005565119.1; XM_005565062.2.
DR RefSeq; XP_005565120.1; XM_005565063.2.
DR RefSeq; XP_005565121.1; XM_005565064.2.
DR SMR; G7PER4; -.
DR Ensembl; ENSMFAT00000055033.2; ENSMFAP00000012080.1; ENSMFAG00000021184.2.
DR Ensembl; ENSMFAT00000080952.1; ENSMFAP00000054529.1; ENSMFAG00000021184.2.
DR Ensembl; ENSMFAT00000085973.1; ENSMFAP00000062831.1; ENSMFAG00000021184.2.
DR Ensembl; ENSMFAT00000088755.1; ENSMFAP00000055662.1; ENSMFAG00000021184.2.
DR Ensembl; ENSMFAT00000092823.1; ENSMFAP00000057432.1; ENSMFAG00000021184.2.
DR Ensembl; ENSMFAT00000092837.1; ENSMFAP00000060185.1; ENSMFAG00000021184.2.
DR Ensembl; ENSMFAT00000093081.1; ENSMFAP00000052677.1; ENSMFAG00000021184.2.
DR Ensembl; ENSMFAT00000096070.1; ENSMFAP00000049897.1; ENSMFAG00000021184.2.
DR Ensembl; ENSMFAT00000102374.1; ENSMFAP00000062884.1; ENSMFAG00000021184.2.
DR Ensembl; ENSMFAT00000102582.1; ENSMFAP00000062367.1; ENSMFAG00000021184.2.
DR GeneID; 101867097; -.
DR KEGG; mcf:101867097; -.
DR CTD; 3185; -.
DR VEuPathDB; HostDB:ENSMFAG00000021184; -.
DR GeneTree; ENSGT00940000157838; -.
DR OMA; SANEQHI; -.
DR OrthoDB; 314723at2759; -.
DR Proteomes; UP000233100; Chromosome 9.
DR Bgee; ENSMFAG00000021184; Expressed in lymph node and 13 other cell types or tissues.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:Ensembl.
DR GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0043484; P:regulation of RNA splicing; IEA:Ensembl.
DR CDD; cd12729; RRM1_hnRNPH_hnRNPH2_hnRNPF; 1.
DR CDD; cd12731; RRM2_hnRNPH_hnRNPH2_hnRNPF; 1.
DR CDD; cd12506; RRM3_hnRNPH_CRSF1_like; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR012996; Znf_CHHC.
DR PANTHER; PTHR13976:SF32; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN F; 1.
DR PANTHER; PTHR13976; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED; 1.
DR Pfam; PF00076; RRM_1; 2.
DR Pfam; PF08080; zf-RNPHF; 1.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
DR PROSITE; PS50102; RRM; 2.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 111..188
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 289..366
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
SQ SEQUENCE 415 AA; 45672 MW; D14E170631FB1F31 CRC64;
MMLGPEGGEG FVVKLRGLPW SCSVEDVQNF LSDCTIHDGA AGVHFIYTRE GRQSGEAFVE
LGSEDDVKMA LKKDRESMGH RYIEVFKSHR TEMDWVLKHS GPNSADSAND GFVRLRGLPF
GCTKEEIVQF FSGLEIVPNG ITLPVDPEGK ITGEAFVQFA SQELAEKALG KHKERIGHRY
IEVFKSSQEE VRSYSDPPLK FMSVQRPGPY DRPGTARRYI GIVKQAGLER MRPGAYSTGY
GGYEEYSGLS DGYGFTTDLF GRDLSYCLSG MYDHRYGDSE FTVQSTTGHC VHMRGLPYKA
TENDIYNFFS PLNPVRVHIE IGPDGRVTGE ADVEFATHEE AVAAMSKDRA NMQHRYIELF
LNSTTGASNG AYSSQVMQGM GVSAAQATYS GLESQSVSGC YGAGYSGQNS MGGYD
//