ID G7PHJ8_MACFA Unreviewed; 1168 AA.
AC G7PHJ8;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=C1q domain-containing protein {ECO:0000259|PROSITE:PS50871};
GN ORFNames=EGM_03107 {ECO:0000313|EMBL:EHH66174.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH66174.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH66174.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- SIMILARITY: Belongs to the caprin family.
CC {ECO:0000256|ARBA:ARBA00007950}.
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DR EMBL; CM001286; EHH66174.1; -; Genomic_DNA.
DR AlphaFoldDB; G7PHJ8; -.
DR eggNOG; ENOG502QQ53; Eukaryota.
DR Proteomes; UP000009130; Chromosome 11.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0017148; P:negative regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR028816; Caprin.
DR InterPro; IPR022070; Caprin-1_C.
DR InterPro; IPR041637; Caprin-1_dimer.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR22922:SF5; CAPRIN-2; 1.
DR PANTHER; PTHR22922; GPI-ANCHORED PROTEIN P137; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF12287; Caprin-1_C; 1.
DR Pfam; PF18293; Caprin-1_dimer; 1.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50871; C1Q; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protein synthesis inhibitor {ECO:0000256|ARBA:ARBA00023193};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 1034..1168
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 46..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 735..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 813..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 986..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 164..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 84..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..463
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..838
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 994..1012
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1168 AA; 130567 MW; E1B9373D239FC45B CRC64;
MLSERQRCLC ISRLPTGLGQ PQARLIWQFR QGRAALLELL ESPVQGREPT GAAGNQRGPA
GLRGFRSARV RRRLGPHLVP RNLRKGSSSV SMVQLSSSPF GYQSPSGHSE EEREGNMKSA
KPQVNHSQHG ESQRALSPLQ STLSSAASPS QAYETYIENG LICLKHKIRN IEKKKLKLED
YKDRLKSGEQ LNPDQLEAVE KYEEVLHNLE FAKELQKTFS GLSLDLLKAQ KKAQRREHML
KLEAEKKKLR TILQVQYVLQ NLTQEHVQKD FKGGLNGAVY LPSKELDYLI KFSKLTCPER
NESLSVEDQM EQSSLYFWDL LEGSEKAVVG TTYKHLKDLL SKLLNSGYFE SIPVPKNAKE
KEVPLEDEML IQSEKKTQLS KTESVKESES LMEFAQPEIQ PQEFLNRRYM TEVDYSNKQG
EEQPWEADYA RKPNLPKRWD MLTEPDGQEK KQESFKSWES PGKHQEVSKP AVSLEQRKQD
TSKLRSTLPE EQKKQEISKS KPSPSQWKQE TPKSKAGYVQ EEQKKQETPK LWPAQLQKEQ
DPKKQTPKSW TPSVQSEQNT TKSWTTPMCE EQDSKQPETP KSWENNVESQ KHSLTSQSQI
SPKSWGVATA SLIPNDQLLP RKFNTEPKDV PKPMHQPVGS SSTLPKDPVL RKEKLQDLMT
QIQGTCNFMQ ESVLDFDKPS SAIPSSQPPS ATPGSPVASK EQNLSSQSDF LQEPLQATST
PVTCSSNACL VTTDQASSGS ETEFMTSETP EAAIPPGKQP SSLASPNPPM AKGSEQGLQS
PPASSSSVTI NTAPFQAMQT VFNVNAPLPP RKEQEIKESS YSSGYNQSFT TASTQTPPQC
QLPSIHVEQT VHSQETANYH PDGTIQVSNG SLAFYPAQTN VFPRPTQPFV NSRGSVRGCT
RGGRLITNSY RSPGGYKGFD TYRGLPSISN GNYSQLQFQA REYSGSPYSQ RCLETSEPLW
LLGKARIISS SVISEEGHLV VHEQIREVSS PERDNETFNS GDSGQGDSRS MTPVDVPVTN
PAATILPVHV YPLPQQMRVA FSAARTSNLA PGTLDQPIVF DLLLNNLGET FDLQLGRFNC
PVNGTYVFIF HMLKLAVNVP LYVNLMKNEE VLVSAYANDG APDHETASNH AILQLFQGDQ
IWLRLHRGAI YGSSWKYSTF SGYLLYQD
//
