ID G7PIH1_MACFA Unreviewed; 540 AA.
AC G7PIH1; A0A2K5VQS7;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Solute carrier family 39 member 5 {ECO:0000313|Ensembl:ENSMFAP00000027131.2};
DE SubName: Full=Zrt-and Irt-like protein 5 {ECO:0000313|EMBL:EHH66394.1};
GN Name=SLC39A5 {ECO:0000313|Ensembl:ENSMFAP00000027131.2};
GN ORFNames=EGM_03378 {ECO:0000313|EMBL:EHH66394.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH66394.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH66394.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000027131.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSMFAP00000027131.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
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DR EMBL; CM001286; EHH66394.1; -; Genomic_DNA.
DR STRING; 9541.ENSMFAP00000027131; -.
DR Ensembl; ENSMFAT00000001314.2; ENSMFAP00000027131.2; ENSMFAG00000044988.2.
DR VEuPathDB; HostDB:ENSMFAG00000044988; -.
DR eggNOG; KOG2693; Eukaryota.
DR GeneTree; ENSGT00940000161155; -.
DR OrthoDB; 5488029at2759; -.
DR Proteomes; UP000009130; Chromosome 11.
DR Proteomes; UP000233100; Chromosome 11.
DR Bgee; ENSMFAG00000044988; Expressed in adult mammalian kidney and 2 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0034224; P:cellular response to zinc ion starvation; IEA:Ensembl.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR GO; GO:0048026; P:positive regulation of mRNA splicing, via spliceosome; IEA:Ensembl.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR PANTHER; PTHR12191:SF17; ZINC TRANSPORTER ZIP5; 1.
DR Pfam; PF02535; Zip; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022906};
KW Zinc {ECO:0000256|ARBA:ARBA00022906};
KW Zinc transport {ECO:0000256|ARBA:ARBA00022906}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..540
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040662614"
FT TRANSMEM 212..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 78..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 540 AA; 56549 MW; AEACEBB95B8C35CE CRC64;
MMGSPVSHLL AGFCVWVILG WVGGSVPNLG PAEQEQNHYL AQLFGLYGEN GTLTAGGLAR
LLHSLGLGRV QGLRLGQHGP LTGRAAPPAA NNSTHRPQNP ELSVDVWAGM PLGPSGWGDL
EESKAPHLPR GPAPSGLDLF HRLLLLDHSL ADHLNEDCLN GSQLLVNFGL SPAAPLTPRQ
FALLCPALLY QIDSRVCIGA PAPAPPGDLL SALLQSALAV LLLSLPSPLS LLLLRLLEPR
LLRPLLGFLG ALAVGTLCGD ALLHLLPHAQ EGRHAGPGGL PEEDLGPGLS VLGGLFLLFV
LENMLGLLRH RGLRPRCCRR KRRDLETRNL DPENGSGMAL QPLQAAPELG AQGQREQNSQ
HPPAPAPPGH QGHSHGHQGG TDITWMVLLG DGLHNLTDGL AIGAAFSDGF SSGLSTTLAV
FCHELPHELG DFAMLLQSGL SFRRLLLLSL VSGALGLGGA VLGVGLSLGP VPLTPWVFGV
TAGVFLYVAL VDMLPALLRP PEPKPTPHVL LQGLGLLLGG GLMLAIALLE EQLLPVTTEG
//
