ID G7PJK3_MACFA Unreviewed; 2206 AA.
AC G7PJK3;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
DE Flags: Fragment;
GN ORFNames=EGM_02874 {ECO:0000313|EMBL:EHH65988.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH65988.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH65988.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma, T-tubule
CC {ECO:0000256|ARBA:ARBA00024012}. Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004415}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004415}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}. Perikaryon
CC {ECO:0000256|ARBA:ARBA00004484}. Postsynaptic density membrane
CC {ECO:0000256|ARBA:ARBA00034112}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. CACNA1C subfamily. {ECO:0000256|ARBA:ARBA00024028}.
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DR EMBL; CM001286; EHH65988.1; -; Genomic_DNA.
DR eggNOG; KOG2301; Eukaryota.
DR Proteomes; UP000009130; Chromosome 11.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030315; C:T-tubule; IEA:UniProtKB-SubCell.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 6.
DR InterPro; IPR031688; CAC1F_C.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005451; VDCC_L_a1csu.
DR InterPro; IPR005446; VDCC_L_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF10; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16885; CAC1F_C; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 5.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01630; LVDCCALPHA1.
DR PRINTS; PR01635; LVDCCALPHA1C.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|PIRSR:PIRSR602077-3};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 115..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 642..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 713..740
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 883..906
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 918..937
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 944..966
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 978..1004
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1025..1058
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1150..1176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1227..1244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1256..1278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1290..1307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1394..1417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1487..1511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1645..1679
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 57..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1765..1827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2014..2078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2171..2190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..796
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1765..1810
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2017..2034
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2046..2078
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2173..2190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 350
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 693
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1122
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT CARBOHYD 315
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-3"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH65988.1"
FT NON_TER 2206
FT /evidence="ECO:0000313|EMBL:EHH65988.1"
SQ SEQUENCE 2206 AA; 246977 MW; 757A0E0913F1049B CRC64;
GSNYGSPRPA HANMNANAAA GLAPEHIPTP GAALSWQAAI DAARQAKLMG SAGNATISTV
SSTQRKRQQY GKPKKQGSTT ATRPPRALLC LTLKNPIRRA CISIVEWKYP LPFEIIILLT
IFANCVALAI YIPFPEDDSN ATNSNLVPRP ANFFCIFSRY GFLKVICTGD FFYPFQSKYS
CPLSLDFLIC KLELFSAILE QATKADGANA LGGKGAGFDV KALRAFRVLR PLRLVSGVPS
LQVVLNSIIK AMVPLLHIAL LVLFVIIIYA IIGLELFMGK MHKTCYNQEG IADVPAEDDP
SPCALETGHG RQCQNGTVCK PGWDGPKHGI TNFDNFAFAM LTVFQCITME GWTDVLYWVN
DAVGRDWPWI YFVTLIIIGS FFVLNLVLGV LSGEFSKERE KAKARGDFQK LREKQQLEED
LKGYLDWITQ AEDIDPENED EGMDEEKPRN MSMPTSETES VNTENVAGGD IEGENCGARL
AHRISKSKFS RYWRRWNRFC RRKCRAAVKS NVFYWLVIFL VFLNTLTIAS EHYNQPHWLT
EVQDTANKAL LALFTAEMLL KMYSLGLQAY FVSLFNRFDC FVVCGGILET ILVETKIMSP
LGISVLRCVR LLRIFKITRY RASPLTLERG LREKFFQRAR EVHLLFSLSH LQSLFGMQLF
GGKFNFDEMQ TRRSTFDNFP QSLLTVFQIL TGEDWNSVMY DGIMAYGGPS FPGMLVCIYF
IILFICGNYI LLNVFLAIAV DNLADAESLT SAQKEEEEEK ERKKLARTAS PEKKQEMVEK
PAVEESKEEK IELKSITADG ESPPTTKINM DDLQPNENED KSPYPNPETT GEEDEEEPEM
PVGPRPRPLS ELHLKEKAVP MPEASAFFVF SSNNRFRLQC HRIVNDTIFT NLILFFILLS
SISLAAEDPV QHTSFRNHIL FYFDIVFTTI FTIEIALKIL GNADYVFTSI FTLEIILKMT
AYGAFLHKGS FCRNYFNILD LLVVSVSLIS FGIQSSAINV VKILRVLRVL RPLRAINRAK
GLKHVVQCVF VAIRTIGNIV IVTTLLQFMF ACIGVQLFKG KLYTCSDSSK QTEAECKGNY
ITYKDGEVDH PIIQPRSWEN SKFDFDNVLA AMMALFTVST FEGWPELLYR SIDSHTEDKG
PIYNYRVEIS IFFIIYIIII AFFMMNIFVG FVIVTFQEQG ETEYKNCELD KNQRQCVEYA
LKARPLRRYI PKNQHQYKVW YVVNSTYFEY LMFVLILLNT ICLAMQHYGQ SCLFKIAMNI
LNMLFTGLFT VEMILKLIAF KPKGYFSDPW NVFDFLIVIG SIIDVILSET NHYFCDAWNT
FDALIVVGSI VDIAITEVNP AEHTQCSPSM NAEENSRISI TFFRLFRVMR LVKLLSRGEG
IRTLLWTFIK SFQALPYVAL LIVMLFFIYA VIGMQVFGKI ALNDTTEINR NNNFQTFPQA
VLLLFRCATG EAWQDIMLAC MPGKKCAPES EPGNSTEGET PCGSSFAVFY FISFYMLCAF
LIINLFVAVI MDNFDYLTRD WSILGPHHLD EFKRIWAEYD PEAKGRIKHL DVVTLLRRIQ
PPLGFGKLCP HRVACKRLVS MNMPLNSDGT VMFNATLFAL VRTALRIKTE GNLEQANEEL
RAIIKKIWKR TSMKLLDQVV PPAGDDEVTV GKFYATFLIQ EYFRKFKKRK EQGLVGKPSQ
RNALSLQAGL RTLHDIGPEI RRAISGDLTA EEELDKAMKE AVSAASEDDI FRRAGGLFGN
HVSYYQSDGR SAFPQTFTTQ RPLHINKAGS SQGDTESPSH EKLVDSTFTP SSYSSTGSNA
NINNANNTAL GRLPRPAGYP STVSTVEGHG PPLSPAIRVQ EVAWKLSSKR ESHALVWEGL
ELRRDSGLAG TQAHCPLLRR ANPSRRGFLS SQTAMVGPEE TSQDETYEVK MNHDAEACSE
PSLLSTDINY RNAPNHSLAR PSMSASVLFS CPDPGSLAGF AGRRASFHLE CLKRQKDRGG
DISQKTVLPL HLVHHQALAV AGLSPLLQRS HSPASFPRPF ATPPATPGSR GWPPQPIPTL
RLEGAESSEK LNSSFPSIHC GSWAETTPGG GDSNTTRRAR PVSLMVPSQA GAPGRQFHGS
ASSLVEAVLI SEGLGQFAQD PKFIEVTTQE LADACDMTIE EMESAADNIL SGGAPQSPNG
ALLPFVNCRD AGQDRAGGEE DAGCARARGR LSEEELQDSR VYVSSL
//
