ID G7PKA6_MACFA Unreviewed; 124 AA.
AC G7PKA6;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=C-type natriuretic peptide {ECO:0000256|ARBA:ARBA00018109};
GN Name=NPPC {ECO:0000313|Ensembl:ENSMFAP00000040170.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000040170.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000040170.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000040170.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU003686}.
CC -!- SIMILARITY: Belongs to the natriuretic peptide family.
CC {ECO:0000256|ARBA:ARBA00009041, ECO:0000256|RuleBase:RU003686}.
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DR AlphaFoldDB; G7PKA6; -.
DR STRING; 9541.ENSMFAP00000040170; -.
DR Ensembl; ENSMFAT00000014437.2; ENSMFAP00000040170.2; ENSMFAG00000046253.2.
DR VEuPathDB; HostDB:ENSMFAG00000046253; -.
DR eggNOG; ENOG502S2QY; Eukaryota.
DR GeneTree; ENSGT00390000015492; -.
DR OrthoDB; 4269066at2759; -.
DR Proteomes; UP000233100; Chromosome 12.
DR Bgee; ENSMFAG00000046253; Expressed in frontal cortex and 1 other cell type or tissue.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0051427; F:hormone receptor binding; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0097746; P:blood vessel diameter maintenance; IEA:UniProtKB-KW.
DR GO; GO:0001974; P:blood vessel remodeling; IEA:Ensembl.
DR GO; GO:0061939; P:c-di-GMP signaling; IEA:Ensembl.
DR GO; GO:1904588; P:cellular response to glycoprotein; IEA:Ensembl.
DR GO; GO:0006182; P:cGMP biosynthetic process; IEA:Ensembl.
DR GO; GO:0051276; P:chromosome organization; IEA:Ensembl.
DR GO; GO:0001549; P:cumulus cell differentiation; IEA:Ensembl.
DR GO; GO:0035483; P:gastric emptying; IEA:Ensembl.
DR GO; GO:0003418; P:growth plate cartilage chondrocyte differentiation; IEA:Ensembl.
DR GO; GO:0003419; P:growth plate cartilage chondrocyte proliferation; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:1903537; P:meiotic cell cycle process involved in oocyte maturation; IEA:Ensembl.
DR GO; GO:0071965; P:multicellular organismal locomotion; IEA:Ensembl.
DR GO; GO:0051447; P:negative regulation of meiotic cell cycle; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:1900194; P:negative regulation of oocyte maturation; IEA:Ensembl.
DR GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR GO; GO:0006457; P:protein folding; IEA:Ensembl.
DR GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; IEA:Ensembl.
DR GO; GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:0048678; P:response to axon injury; IEA:Ensembl.
DR GO; GO:0002931; P:response to ischemia; IEA:Ensembl.
DR GO; GO:0090649; P:response to oxygen-glucose deprivation; IEA:Ensembl.
DR InterPro; IPR002406; C_natriurtcpep.
DR InterPro; IPR000663; Natr_peptide.
DR InterPro; IPR030480; Natr_peptide_CS.
DR PANTHER; PTHR12167; C-TYPE NATRIURETIC PEPTIDE; 1.
DR PANTHER; PTHR12167:SF2; C-TYPE NATRIURETIC PEPTIDE; 1.
DR Pfam; PF00212; ANP; 1.
DR PRINTS; PR00713; CNATPEPTIDE.
DR PRINTS; PR00710; NATPEPTIDES.
DR SMART; SM00183; NAT_PEP; 1.
DR PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE 3: Inferred from homology;
KW Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Vasoactive {ECO:0000256|ARBA:ARBA00022858, ECO:0000256|RuleBase:RU003686}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..124
FT /note="C-type natriuretic peptide"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030172132"
FT REGION 20..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 124 AA; 13127 MW; 4C5902AB84CAD408 CRC64;
MHLSQLLACA LLLTLLSLRP SEAKPGAPPK VPRTPPGEEL AEPQAAGGGQ KKGDKAPGGA
NLKGDRSRLL RDLRVDTKSR AAWARLLHEH PNARKYKGAN KKGLSKGCFG LKLDRIGSMS
GLGC
//
