ID G7PL97_MACFA Unreviewed; 763 AA.
AC G7PL97;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=Disintegrin and metalloproteinase domain-containing protein 23 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=EGM_04245 {ECO:0000313|EMBL:EHH55106.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH55106.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH55106.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM001287; EHH55106.1; -; Genomic_DNA.
DR AlphaFoldDB; G7PL97; -.
DR MEROPS; M12.979; -.
DR eggNOG; KOG3607; Eukaryota.
DR Proteomes; UP000009130; Chromosome 12.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR006586; ADAM_Cys-rich.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR InterPro; IPR002870; Peptidase_M12B_N.
DR InterPro; IPR034027; Reprolysin_adamalysin.
DR PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR PANTHER; PTHR11905:SF13; DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 23; 1.
DR Pfam; PF08516; ADAM_CR; 1.
DR Pfam; PF00200; Disintegrin; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF01562; Pep_M12B_propep; 1.
DR Pfam; PF01421; Reprolysin; 1.
DR SMART; SM00608; ACR; 1.
DR SMART; SM00050; DISIN; 1.
DR SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 230..427
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT DOMAIN 433..519
FT /note="Disintegrin"
FT /evidence="ECO:0000259|PROSITE:PS50214"
FT DOMAIN 663..700
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 491..511
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00068"
FT DISULFID 690..699
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH55106.1"
FT NON_TER 763
FT /evidence="ECO:0000313|EMBL:EHH55106.1"
SQ SEQUENCE 763 AA; 85457 MW; 3F806797EABD11DE CRC64;
PPAPRWNETA EKNLGVLAEE DNTLQQNSSS NISYSNAMQK EITLPSRLIY YINQDSESPY
HVLDTKARHQ QKHNKAVHLA QASFQIEAFG SKFILDLILN NGLLSSDYVE IHYENGKPQY
SKGGEHCYYH GSIRGVKDSK VALSTCNGLH GMFEDDTFVY MIEPLELVHD EKSTGRPHII
QKTLAGQYSK QMKNLTMERG DQWPFLSELQ WLKRRKRAVN PSRGIFEEMK YLELMIVNDH
KTYKKHRSSH AHTNNFAKSV VNLVDSIYKE QLNTRVVLVA VETWTERDQI DITTNPVQML
HEFSKYRQRI RQHADAVHLI SRVTFHYKRS SLSYFGGVCS RTRGVGVNEY GLPMAVAQVL
SQSLAQNLGI QWEPSSRKPK CDCTESWGGC IMEETGVSHS RKFSKCSVLE YRDFLQRGGG
ACLFNRPTKL FEPTECGNGY VEAGEECDCG FHVECYGLCC KKCSLSNGAH CSDGPCCNNT
SCLFQPRGYE CRDAVNECDI TEYCTGDSGQ CPPNLHKQDG YACNQNQGRC YNGECKTRDN
QCQYIWGTKA AGSDKFCYEK LNTEGTEKGN CGKDGDRWIQ CSKHDVFCGF LLCTNLTRAP
RIGQLQGEII PTSFYHQGRV IDCSGAHVVL DDDTDVGYVE DGTPCGPSMM CLDRKCLQIQ
ALNMSSCPLD SKGKVCSGHG VCSNEATCIC DFTWAGTDCS IRDPVRNLHP PKDEGPKEMS
RREGLILLSK APSESAALDG HHLALLDSGY DILAAVLPEL LSL
//
