ID   G7PLG6_MACFA            Unreviewed;       819 AA.
AC   G7PLG6;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=TFIIS N-terminal domain-containing protein {ECO:0000259|PROSITE:PS51319};
GN   ORFNames=EGM_05219 {ECO:0000313|EMBL:EHH55917.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1] {ECO:0000313|EMBL:EHH55917.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CE-4 {ECO:0000313|EMBL:EHH55917.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA   Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA   Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA   Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA   Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA   Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal models,
RT   the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00649}.
CC   -!- SIMILARITY: Belongs to the IWS1 family.
CC       {ECO:0000256|ARBA:ARBA00037992}.
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DR   EMBL; CM001288; EHH55917.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7PLG6; -.
DR   eggNOG; KOG1793; Eukaryota.
DR   Proteomes; UP000009130; Chromosome 13.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR017923; TFIIS_N.
DR   PANTHER; PTHR46010; PROTEIN IWS1 HOMOLOG; 1.
DR   PANTHER; PTHR46010:SF1; PROTEIN IWS1 HOMOLOG; 1.
DR   Pfam; PF08711; Med26; 1.
DR   SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR   PROSITE; PS51319; TFIIS_N; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00649}.
FT   DOMAIN          614..692
FT                   /note="TFIIS N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51319"
FT   REGION          1..520
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          696..728
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..71
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..463
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        475..493
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        494..520
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        698..714
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   819 AA;  91925 MW;  525ACCC4C608D1B6 CRC64;
     MDSEYYSGDQ SDDGGATPVQ DERDSGSDGE DDVNEQHSGS DTGSVERHSE NEPSDREDGL
     TKGHHVIDSE NDEPINLNAS DSESEDLHRQ KDSDSESEER AEPPASDSEN EDVNQHGSDS
     ESEETRKLPG SDSENEELLN GHASDSENED VGKHPASDSE IEELQKSPAS DSETEDALKP
     QISDSESEEP PRHQASDSEN EEPPKPRMSD SESEELPKPQ VSDSESEEPP RHQASDSENE
     ELPKPRISDS ESEDPPRHQA TDSENEELPK PRISDSESED PPRNQASDSE NEELPKPRVS
     DSESEGPRKG PASDSETEDA SRHKQKPESD DDSDRENKGE DTEMQNDSFH SDSHMDRKKF
     HSSDSEEEEP KKQKLDSDED EKEGEEEKVA KRKAAVLSDS EDGEKASAKK SRVVSDADDS
     DSDAVSDKSG KREKTIASDS EEEAGKELSD KKNEEKDLFG SDSESGNEEE NLIADIFGES
     GDEEEEEFTG FNQEDLEEEK SETQVKEAED SDSDDNIKRG KHMDFLSDFE MMLQRKKSMS
     GKRRRNRDGG TFISDADDVV SAMIVKMNEA AEEDRQLNNQ KKPALKKLTL LPTVVMHLKK
     QDLKETFIDS GVMSAIKEWL SPLPDRSLPA LKIREELLKI LQELPSVSQE TLKHSGIGRA
     VMYLYKHPKE SRSNKDMAGK LINEWSRPIF GLTSNYKGMT REEREQRDLE QMPQRRRMNS
     TGGQTPRRDL EKVLTGEEKA LRPGDPGFCA RARVPMPSNK DYVVRPKWNV EMESSRFQAT
     SKKGISRLDK QMRKFTDIRK KSRSAHAVKI SIEGNKMPL
//