ID G7PM26_MACFA Unreviewed; 1055 AA.
AC G7PM26;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 13-SEP-2023, entry version 58.
DE RecName: Full=Son of sevenless homolog 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=EGM_04743 {ECO:0000313|EMBL:EHH55521.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH55521.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH55521.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
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DR EMBL; CM001288; EHH55521.1; -; Genomic_DNA.
DR AlphaFoldDB; G7PM26; -.
DR eggNOG; KOG3417; Eukaryota.
DR Proteomes; UP000009130; Chromosome 13.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd01261; PH_SOS; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 6.10.250.3060; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF168; SON OF SEVENLESS HOMOLOG 1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 1..122
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 175..278
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 329..474
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 513..756
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 756..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 869..883
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 912..928
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..993
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1043
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1055 AA; 120376 MW; 05903241B566F064 CRC64;
MTDEGSPHPL VGSCFEDLAE ELAFDPYESY ARDILRPGFH DRFLSQLSKP GAALYLQSIG
EGFKEAVQYV LPRLLLAPVY HCLHYFELLK QLEEKSEDQE DKECLKQAIT ALLNVQSGME
KICSKSLAKR RLSESACRFY SQQMKGKQLA IKKMNEIQKN IDGWEGKDIG QCCNEFIMEG
TLTRVGAKHE RHIFLFDGLM ICCKSNHGQP RLPGASNAEY RLKEKFFMRK VQINDKDDTN
EYKHAFEIIL KDENSVIFSA KSAEEKNNWM AALISLQYRS TLERMLDVTM LQEEKEEQMR
LPSADVYRFA EPDSEENIIF EENMQPKAGI PIIKAGTVIK LIERLTYHMY ADPNFVRTFL
TTYRSFCKPQ ELLSLIIERF EIPEPEPTEA DRIAIENGDQ PLSAELKRFR KEYIQPVQLR
VLNVCRHWVE HHFYDFERDA YLLQRMEEFI GTVRAGKAMK KWVESITKII QRKKIARDNG
PGHNITFQSS PPTVEWHISR PGHIETFDLL TLHPIEIARQ LTLLESDLYR YVLPFPGILT
AWQWYWKDPS TPSLNAVPRN VGNIGTELFL EICIVETENL EERVAVVSRI IEILQVFQEL
NNFNGVLEVV SAMNSSPVYR LDHTFEQIPS RQKKILEEAH ELSEDHYKKY LAKLRSINPP
CVPFFVLGIY LTNILKTEEG NPEVLKRHGK ELINFSKRRK VAEITGEIQQ YQNQPYCLRV
ESDIKRFFEN LNPMGNSMEK EFTDYLFNKS LEIEPRNPKP LPRFPKKYSY PLKSPGVRPS
NPRPGTMRHP TPLQQEPRKI SYSRIPESET ESTASAPNSP RTPLTPPPAS GASSTTDVCS
VFDSDHSSPF HSRSASVSSI SLTKGTDEVP VPPPVPPRRR PESAPAESSP SKIMSKHLDS
PPAIPPRQPT SKAYSPRYSI SDRTSISDPP ESPPLLPPRE PVRTPDVFSS SPLHLQPPPL
GKKSDHGNAF FPNSPSPFTP PPPQTPSPHG TRRHLPSPPL TQEVDLHSIA GPPVPPRQST
SQHIPKLPPK TYKREHTHPS MHRDGPPLLE NAHSS
//
