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Database: UniProt
Entry: G7PNJ1_MACFA
LinkDB: G7PNJ1_MACFA
Original site: G7PNJ1_MACFA 
ID   G7PNJ1_MACFA            Unreviewed;       785 AA.
AC   G7PNJ1;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   24-JAN-2024, entry version 60.
DE   RecName: Full=Progesterone receptor {ECO:0000256|ARBA:ARBA00013488, ECO:0000256|RuleBase:RU368037};
DE            Short=PR {ECO:0000256|RuleBase:RU368037};
DE   AltName: Full=Nuclear receptor subfamily 3 group C member 3 {ECO:0000256|ARBA:ARBA00031166, ECO:0000256|RuleBase:RU368037};
GN   ORFNames=EGM_06148 {ECO:0000313|EMBL:EHH56686.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1] {ECO:0000313|EMBL:EHH56686.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CE-4 {ECO:0000313|EMBL:EHH56686.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA   Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA   Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA   Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA   Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA   Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal models,
RT   the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
CC   -!- FUNCTION: Steroid hormone receptor involved in the regulation of
CC       eukaryotic gene expression which affects cellular proliferation and
CC       differentiation in target tissues. {ECO:0000256|RuleBase:RU368037}.
CC   -!- FUNCTION: The steroid hormones and their receptors are involved in the
CC       regulation of eukaryotic gene expression and affect cellular
CC       proliferation and differentiation in target tissues. Transcriptional
CC       activator of several progesteron-dependent promoters in a variety of
CC       cell types. Involved in activation of SRC-dependent MAPK signaling on
CC       hormone stimulation. {ECO:0000256|ARBA:ARBA00003111}.
CC   -!- SUBUNIT: Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the
CC       interaction promotes ubiquitination, decreases sumoylation, and
CC       represses transcriptional activity. Interacts with PIAS3; the
CC       interaction promotes sumoylation of PR in a hormone-dependent manner,
CC       inhibits DNA-binding, and alters nuclear export. Interacts with SP1;
CC       the interaction requires ligand-induced phosphorylation on Ser-345 by
CC       ERK1/2-MAPK. Interacts with PRMT2. Interacts with NCOA2 and NCOA1.
CC       Interacts with KLF9. Interacts with GTF2B.
CC       {ECO:0000256|ARBA:ARBA00025942}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU368037}.
CC       Cytoplasm {ECO:0000256|RuleBase:RU368037}.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC       DNA-binding domain and a C-terminal ligand-binding domain.
CC       {ECO:0000256|RuleBase:RU368037}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000256|ARBA:ARBA00005993, ECO:0000256|RuleBase:RU004334}.
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DR   EMBL; CM001289; EHH56686.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7PNJ1; -.
DR   eggNOG; KOG3575; Eukaryota.
DR   Proteomes; UP000009130; Chromosome 14.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003707; F:nuclear steroid receptor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005496; F:steroid binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   CDD; cd07172; NR_DBD_GR_PR; 1.
DR   CDD; cd07074; NR_LBD_PR; 1.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR000128; Progest_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR48092; KNIRPS-RELATED PROTEIN-RELATED; 1.
DR   PANTHER; PTHR48092:SF6; PROGESTERONE RECEPTOR; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF02161; Prog_receptor; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00544; PROGESTRONER.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|RuleBase:RU368037};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121,
KW   ECO:0000256|RuleBase:RU368037};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU004334};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW   Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW   Steroid-binding {ECO:0000256|ARBA:ARBA00022665,
KW   ECO:0000256|RuleBase:RU368037};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU004334};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU004334};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT   DOMAIN          416..491
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000259|PROSITE:PS51030"
FT   DOMAIN          531..765
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51843"
FT   REGION          1..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          331..356
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..84
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..137
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        162..176
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   785 AA;  84462 MW;  13B349AC551D0E25 CRC64;
     MTELKAKSPR APHVAGGPPS PEVGSPLLCR PAAGPFQGSQ TSDTLPEVSA IPISLDGLLF
     PRPCQGQDPL DEKTQDQQSL SDVEGAYSRA EATRGTGGSS SRPPEKDSGL LDSVLDTLLA
     PSGPGQSQPS PPASEVTSSW CLFGPELPED PPAAPATPAT QRVLSPLMSR SGGKAGDSSE
     TAAAHKVLPR GLSPSRQLLL PASGSPHWSG APVKPSPLPT AVEVEEEDGS ESEDSAGPLL
     KGKPRALGGA AAGGGAAAVP PGAAAGGVAL VPKEDSRFSA PRVALVEQDA PMAPGRSPLA
     TTTMDFTHVP ILPLNHALLA ARTRQLLEEE SYDGGAGAAS AFAPPRSSPS ASSTPVAVGD
     FPDCAYPPDA DPKDDAYPLY GDFQPPALKI KEEEEGARPD SEASQSPQYS FESLPQKICL
     ICGDEASGCH YGVLTCGSCK VFFKRAMEGQ HNYLCAGRND CIVDKIRRKN CPACRLRKCC
     QAGMVLGGRK FKKFNKVRVM RALDAVALPQ PVGIPNESQA LSQRFTFSPG QDIQLIPPLI
     NLLVSIEPDV IYAGHDNSKP DTSSSLLTSL NQLGERQLLS VVKWSKLLPG FRNLHIDDQI
     TLIQYSWMSL MVFGLGWRSY KHVSGQMLYF APDLILNEQR MKESSFYSLC LTMWQIPQEF
     VKLQVSQEEF LCMKVLLLLN TIPLEGLRSQ TQFEEMRSSY IRELIKAIGL RQKGVVSSSQ
     RFYQLTKLLD NLHDLVKQLH LYCLNTFIQS RALSVEFPEM MSEVIAAQLP KILAGMVKPL
     LFHKK
//
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