ID G7PRN4_MACFA Unreviewed; 101 AA.
AC G7PRN4;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=SOSS complex subunit C {ECO:0000256|ARBA:ARBA00014540, ECO:0000256|RuleBase:RU369016};
DE Short=SOSS-C {ECO:0000256|RuleBase:RU369016};
DE Short=SSB-interacting protein 1 {ECO:0000256|RuleBase:RU369016};
DE AltName: Full=Sensor of single-strand DNA complex subunit C {ECO:0000256|ARBA:ARBA00030383, ECO:0000256|RuleBase:RU369016};
DE AltName: Full=Sensor of ssDNA subunit C {ECO:0000256|ARBA:ARBA00033066, ECO:0000256|RuleBase:RU369016};
DE AltName: Full=Single-stranded DNA-binding protein-interacting protein 1 {ECO:0000256|ARBA:ARBA00031967, ECO:0000256|RuleBase:RU369016};
GN Name=INIP {ECO:0000313|Ensembl:ENSMFAP00000024547.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000024547.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000024547.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000024547.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the SOSS complex, a multiprotein complex that
CC functions downstream of the MRN complex to promote DNA repair and G2/M
CC checkpoint. The SOSS complex associates with single-stranded DNA at DNA
CC lesions and influences diverse endpoints in the cellular DNA damage
CC response including cell-cycle checkpoint activation, recombinational
CC repair and maintenance of genomic stability. Required for efficient
CC homologous recombination-dependent repair of double-strand breaks
CC (DSBs). {ECO:0000256|RuleBase:RU369016}.
CC -!- SUBUNIT: Component of the SOSS complex.
CC {ECO:0000256|RuleBase:RU369016}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369016}.
CC -!- SIMILARITY: Belongs to the SOSS-C family.
CC {ECO:0000256|ARBA:ARBA00007829, ECO:0000256|RuleBase:RU369016}.
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DR AlphaFoldDB; G7PRN4; -.
DR SMR; G7PRN4; -.
DR STRING; 9541.ENSMFAP00000024547; -.
DR Ensembl; ENSMFAT00000032687.2; ENSMFAP00000024547.2; ENSMFAG00000043846.2.
DR VEuPathDB; HostDB:ENSMFAG00000043846; -.
DR eggNOG; ENOG502S23S; Eukaryota.
DR GeneTree; ENSGT00390000006366; -.
DR OrthoDB; 2913067at2759; -.
DR Proteomes; UP000233100; Chromosome 15.
DR Bgee; ENSMFAG00000043846; Expressed in cerebellum and 13 other cell types or tissues.
DR GO; GO:0070876; C:SOSS complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0010212; P:response to ionizing radiation; IEA:UniProtKB-UniRule.
DR InterPro; IPR031821; SOSSC.
DR PANTHER; PTHR31526; SOSS COMPLEX SUBUNIT C; 1.
DR PANTHER; PTHR31526:SF2; SOSS COMPLEX SUBUNIT C; 1.
DR Pfam; PF15925; SOSSC; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU369016};
KW DNA repair {ECO:0000256|RuleBase:RU369016};
KW Nucleus {ECO:0000256|RuleBase:RU369016};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
SQ SEQUENCE 101 AA; 11204 MW; 4550A5E0EF9F6A52 CRC64;
MPPSLGFQNK NRVAILAELD KEKRKLLMQN QSSTNHPGAS IALSRPSLNK DFRDHAEQQH
IAAQQKAALQ HAHAHSSGYF ITQDSAFGNL ILPVLPRLDP E
//
