ID G7PVS0_MACFA Unreviewed; 676 AA.
AC G7PVS0;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 22-FEB-2023, entry version 29.
DE RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
DE Flags: Fragment;
GN ORFNames=EGM_08641 {ECO:0000313|EMBL:EHH58721.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH58721.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH58721.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR EMBL; CM001292; EHH58721.1; -; Genomic_DNA.
DR AlphaFoldDB; G7PVS0; -.
DR eggNOG; KOG2167; Eukaryota.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000009130; Chromosome 17.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF68; CULLIN-4A; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 321..549
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EHH58721.1"
FT NON_TER 676
FT /evidence="ECO:0000313|EMBL:EHH58721.1"
SQ SEQUENCE 676 AA; 78706 MW; 72D03E37C5419549 CRC64;
QAVENLCSHK VSPMLYKQLR QACEDHVQAQ ILPFREYPFF DSLDSVLFLK KINTCWQDHC
RQMIMIRSIF LFLDRTYVLQ NSTLPSIWDM GLELFRTHII SDKMVQSKTI DGILLLIEHE
RSGEAVDRSL LRSLLGMLSD LQVYKDSFEL KFLEETNCLY AAEGQRLMQE REVPEYLNHV
SKRLEEEGDR VITYLDHGTQ KPLIACVEKQ LLGEHLTAIL QKGLDHLLDE NRVPDLAQMY
QLFSRVRGGQ QALLQHWSEY IKTFGTAIVI NPEKDKDMVQ DLLDFKDKVD HVIEVCFQKN
ERFVNLMKES FETFINKRPN KPAELIAKHV DSKLRAGNKE ATDEELERTL DKIMILFRFI
HGKDVFEAFY KKDLAKRLLV GKSASVDAEK SMLSKLKHEC GAAFTSKLEG MFKDMELSKD
IMVHFKQHMQ NQSDSGPIDL TVNILTMGYW PTYTPMEVHL TPEMVKLQEV FKAFYLGKHS
GRKLQWQTTL GHAVLKAEFK EGKKEFQVSL FQTLVLLMFN EGDGFSFEEI KMATGIEDSE
LRRTLQSLAC GKARVLIKSP KGKEVEDGDK FIFNGEFKHK LFRIKINQIQ MKETVEEQVS
TTERVFQDRQ YQIDAAIVRI MKMRKTLGHN LLVSELYNQL KFPVKPGDLK KRIESLIDRD
YMERDKDNPN QYHYVA
//
