ID G7PZH6_MACFA Unreviewed; 983 AA.
AC G7PZH6;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Lysosomal alpha-mannosidase {ECO:0000256|ARBA:ARBA00044166};
DE AltName: Full=Lysosomal acid alpha-mannosidase {ECO:0000256|ARBA:ARBA00044241};
DE AltName: Full=Mannosidase alpha class 2B member 1 {ECO:0000256|ARBA:ARBA00044220};
DE AltName: Full=Mannosidase alpha-B {ECO:0000256|ARBA:ARBA00044360};
GN ORFNames=EGM_09314 {ECO:0000313|EMBL:EHH59246.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH59246.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH59246.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
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DR EMBL; CM001294; EHH59246.1; -; Genomic_DNA.
DR AlphaFoldDB; G7PZH6; -.
DR Proteomes; UP000009130; Chromosome 19.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10810; GH38N_AMII_LAM_like; 1.
DR Gene3D; 2.60.40.1360; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 2.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR048534; Man2a1-like_dom.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF3; LYSOSOMAL ALPHA-MANNOSIDASE; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR Pfam; PF21260; Laman-like_dom; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..50
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 51..983
FT /note="Lysosomal alpha-mannosidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003502975"
FT DOMAIN 388..467
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 983 AA; 110423 MW; B94DC9E3D0E0AC38 CRC64;
MGAYAPAAGV SARGCLDAAG PWTISRALRP PLPPLCFFLL LLLAAPGARA GGYETCPAVQ
PNMLNVHLVP HTHDDVGWLK TVDQYFYGIK NDIQHAGVQY ILDSVISALL ADPTRRFIYV
EIAFFSRWWH QQTNAMREVV RDLVRQGRLE FANGGWVMND EAATHYGAIV DQMTLGLRFL
EDTFGSDGRP RVAWHIDPFG HSREQASLFA QMGFDGFFFG RLDYQDKRVR MQKLEMEQVW
RASASLKPPT ADLFTGVLPN GYNPPMNLCW DVLCVDQPVV EDPRSPEYNA KELVDYFLNV
ATAQGRHYRT NHIVMTMGSD FQYENANMWF KNLDKLIRLV NAQQQAKGSS VHVLYSTPAC
YLWELNKANL TWSVKHDDFF PYADGPHQFW TGYFSSRPAL KRYERLSYNF LQVCNQLEAL
VGLAANVGPY GSGDSAPLNK AMAVLQHHDA VSGTSRQHVA DDYARQLAAG WGSCEFQVIV
YNPLGRKANW MVRLPVSEGV FVVKDPNGRT VPSDVVIYPS SDSQAHPPEL LFSASLPALG
FSTYSVAQVP RWKPQARAPQ PIPRRSWSPA LTIENEHIRA TFDPDTGLLM EIMNMNQRLL
LPVRQTFFWY NASVGDNESD QASGAYIFRP NQQKPLPVSR WAQIRLVKTP LVQEVHQNFS
AWCSQVVRLY PGQRHLELEW SVGPIPVGDT WGKEVISRFD TPLETKGRFY TDSNGREILE
RRRDYRPTWK LNQTEPVAGN YYPVNTRIYI TDGKMQLTVL TDRSQGGSSL RDGSLELMVH
RRLLKDDERG VSEPLMENGS GAWVRGRHLV LLDTAQAAAA GHRLLAEQEV LAPQVVLAPG
GGAAYNLGAP PRTQFSGLRR ELPPSVHLLT LASWGPEMLL LRLEHQFAVG EDSGRNLSAP
VTLNLRDLFS TFTITRLQET TLVANQLREA ASRLKWTTNT GGALVRGPTP HQTPYQLDPA
NITLEPMEIR TFLASVQWKE VDG
//
