ID G7PZR3_MACFA Unreviewed; 1605 AA.
AC G7PZR3;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=NACHT and WD repeat domain-containing protein 1 {ECO:0000313|EMBL:EHH59333.1};
GN ORFNames=EGM_09415 {ECO:0000313|EMBL:EHH59333.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH59333.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH59333.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
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DR EMBL; CM001294; EHH59333.1; -; Genomic_DNA.
DR eggNOG; KOG0265; Eukaryota.
DR eggNOG; KOG3602; Eukaryota.
DR Proteomes; UP000009130; Chromosome 19.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR025139; DUF4062.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR043365; NWD1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR45013; NACHT DOMAIN- AND WD REPEAT-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45013:SF1; NACHT DOMAIN- AND WD REPEAT-CONTAINING PROTEIN 1; 1.
DR Pfam; PF13271; DUF4062; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 12.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 32..130
FT /note="DUF4062"
FT /evidence="ECO:0000259|Pfam:PF13271"
FT DOMAIN 378..549
FT /note="NACHT"
FT /evidence="ECO:0000259|Pfam:PF05729"
FT REPEAT 905..946
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 947..988
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1165..1206
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1425..1459
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 1605 AA; 179129 MW; B92AEBD2C2E420F3 CRC64;
MSVGPLSPST RRRLLQGEAG PLPPPPPTGV TIFISSTVSD MDAEREALQS TAYPEVQSFC
QKHGLMFEVV DLRWGIRNTE VTDLLTTELC LEEVDRCWKT SIGPAFVALI GDQYGPCVVP
SRIDEKEWEV LRARLTARPS DLELVARHFR RDENAVPPTY ILQAPGTGEA CEPEEATLTS
VLRSGAQEAR RLGLITQEQW QRYHRSVIDW EIQQGLLSSE ERDQGATVFL REIQDLYKHI
LEDCALGMVD RLADGCLDTD AQNLLSSLKG HITDMHPEVL KAHRLPWSRD LVNPKNKTHA
QYLKELGEQF VARANHQVLE RLRELDVAGQ ELAWLYQEIR HHLWQSSEVT QNFCGRQELL
ARLGQQLRHD DSKQHTPLVL FGPPGIGKTA LMCKLVEQMP RLLGHKTVTV LRLLGTSQMS
SDARGLLKSI CFQVCLAYGL PLPRAQVLDA HTRVVQFFHT LLHTVSCRNF ESLVLLLDAM
DDLDSVRHAR RVPWLPLNCP PRVHLILSAC SGALGVLDTL QRVLLDPEAY WEVKPLSGNQ
GQEMIQHLLV AARRTLSPVH TDLLWASLPE CGNPGRLRLA FEEARKWVSF TVPAPLATTA
EEATHQLCAR LEQTHGRLLV AHVLGYIVSS RHGLSEAELK DVLSLDDEVL QAVYRDWTPP
SKELLRFPPL LWVRLRRDLG YYLARRPVDG FTLLAIAHRQ LVEVVRERYL SGSERAKRHG
VLADFFSGTW SQGTKKLITL PLVGKPLNLD RKVAPQPLWF SDTVANLRKL KELPYHLLHS
GRLEELKQEV LGSMSWISCR GISGGIEDLL DDFDLCAPHL DSPEVGLVRE ALQLCRPAVE
LRGMERSLLY TELLARLHFF TTSHPALVGQ LCQQAQSWFR LCAHPVLVPL GGFLQPPGGP
LRATLSGCHK GITAMAWGVE EKLLVIGTQD GIIAVWDMEE QHVIHMLTGH TGEVRCVKVF
AKGTLAISAS KDYTLRLWNL LTGQEKFAIW DGGSKNPTEP QIWSLHVDEA HKVVYSASAS
KINAWNLETA ELVFHILGDA SDPWMCMAML ASQATLLTVS RGGVVSLWSS ATGKLQGQQH
MSSIKEETPT CAVSVQKQGK LVTGFSNGSI SLVSSKEDRL LEKLPDAVRF LVVSEDESLL
AAGFGRSVRI FSADWRGFRR FMATDLEHED MVETAVFGPE NNLIVTGSLD ALIQVWSLSE
QGTLLDILEG VGAPVSLLAR GGTLVASASL QSSSFKVWDL SNAHRSRVPA PFLDRTGLTA
VSHNGSYVYF PKIGDKNKVT IWDLAEGEEQ DSLDASSEVR CLEVAEQHKL LFTGLVSGVV
LVFPLNSRQD VICIPPPEAR KAIHCMSLSK WEDRLAVAYD NMVLVLDIAP GDPCPVINGP
RYTFYTQLPE TISSVAILTD YRMVYSMTNG DLFLYECANS KAFPLEAHRS RVACVEVSHK
EQLVVSGSED ALLRLWDLQA RKWKFEMSYT SSYCRGVQCA CFSKDDKYVY VGLKDRSILV
WSVLDGTLLT VQFVHAVVNR IIPTTSGFIA PTRHGYLIRE RFQCLSARTS QQDPLRNFKK
AVWMVKSRQR EELVAAVGAH RDLESESAQG NETKSNKCSQ VCLIV
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