ID G7Q2J9_MACFA Unreviewed; 312 AA.
AC G7Q2J9;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Farnesyl pyrophosphate synthase {ECO:0000256|ARBA:ARBA00034546};
DE AltName: Full=(2E,6E)-farnesyl diphosphate synthase {ECO:0000256|ARBA:ARBA00032873};
DE AltName: Full=Dimethylallyltranstransferase {ECO:0000256|ARBA:ARBA00032448};
DE AltName: Full=Farnesyl diphosphate synthase {ECO:0000256|ARBA:ARBA00032424};
DE AltName: Full=Geranyltranstransferase {ECO:0000256|ARBA:ARBA00032380};
GN ORFNames=EGM_18703 {ECO:0000313|EMBL:EHH60828.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH60828.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH60828.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)-
CC farnesyl diphosphate + diphosphate; Xref=Rhea:RHEA:19361,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:58057, ChEBI:CHEBI:128769,
CC ChEBI:CHEBI:175763; EC=2.5.1.10;
CC Evidence={ECO:0000256|ARBA:ARBA00001744};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=dimethylallyl diphosphate + isopentenyl diphosphate = (2E)-
CC geranyl diphosphate + diphosphate; Xref=Rhea:RHEA:22408,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57623, ChEBI:CHEBI:58057,
CC ChEBI:CHEBI:128769; EC=2.5.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000969};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis;
CC farnesyl diphosphate from geranyl diphosphate and isopentenyl
CC diphosphate: step 1/1. {ECO:0000256|ARBA:ARBA00005035}.
CC -!- PATHWAY: Isoprenoid biosynthesis; geranyl diphosphate biosynthesis;
CC geranyl diphosphate from dimethylallyl diphosphate and isopentenyl
CC diphosphate: step 1/1. {ECO:0000256|ARBA:ARBA00004932}.
CC -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC {ECO:0000256|RuleBase:RU004466}.
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DR EMBL; CM001296; EHH60828.1; -; Genomic_DNA.
DR AlphaFoldDB; G7Q2J9; -.
DR Proteomes; UP000009130; Chromosome X.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 2.
DR InterPro; IPR039702; FPS1-like.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR000092; Polyprenyl_synt.
DR InterPro; IPR033749; Polyprenyl_synt_CS.
DR PANTHER; PTHR11525:SF0; FARNESYL PYROPHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR11525; FARNESYL-PYROPHOSPHATE SYNTHETASE; 1.
DR Pfam; PF00348; polyprenyl_synt; 2.
DR SUPFAM; SSF48576; Terpenoid synthases; 1.
DR PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Transferase {ECO:0000256|RuleBase:RU004466}.
SQ SEQUENCE 312 AA; 35309 MW; 14BEAE0FF8E77CEF CRC64;
MNGDQKSDVY AQGKQDFIQH FSQIVRVLTE DEMGYSETGD AIAQLKEVLE YNAIGGKYHQ
GLTVLVASRE LVEPRKQDAD SLQRALTMGW FVELLQAFFL VADDIMDSSL SPQGQIWWYQ
KPSMGLDAIN DAMLPEAWQW GGVGLGRFTE KRYKSIVKYK AAFYSYLPVA AAMYIAGIDG
EKNHANAKKI LLDMGEFFQI QDDYLDLFGD PSVTSKVGAD IQDNKCSWLV VQRLQQATPE
QYQILKKNYG QKEAKKVAQV KALYEELDLP AVGLQYEEDS YSHIMGLIEQ YAAPLTPAIF
LGLLRKIYKQ KK
//
