ID G7Q364_MACFA Unreviewed; 720 AA.
AC G7Q364; A0A2K5X550;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Kelch like family member 4 {ECO:0000313|Ensembl:ENSMFAP00000044430.2};
GN Name=KLHL4 {ECO:0000313|Ensembl:ENSMFAP00000044430.2};
GN ORFNames=EGM_18964 {ECO:0000313|EMBL:EHH61043.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000313|EMBL:EHH61043.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CE-4 {ECO:0000313|EMBL:EHH61043.1};
RX PubMed=22002653; DOI=10.1038/nbt.1992;
RA Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT "Genome sequencing and comparison of two nonhuman primate animal models,
RT the cynomolgus and Chinese rhesus macaques.";
RL Nat. Biotechnol. 29:1019-1023(2011).
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000044430.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSMFAP00000044430.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; CM001296; EHH61043.1; -; Genomic_DNA.
DR RefSeq; XP_005594130.1; XM_005594073.2.
DR STRING; 9541.ENSMFAP00000044430; -.
DR Ensembl; ENSMFAT00000018724.2; ENSMFAP00000044430.2; ENSMFAG00000039559.2.
DR GeneID; 101925929; -.
DR KEGG; mcf:101925929; -.
DR CTD; 56062; -.
DR VEuPathDB; HostDB:ENSMFAG00000039559; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000159818; -.
DR OrthoDB; 5472491at2759; -.
DR Proteomes; UP000009130; Chromosome X.
DR Proteomes; UP000233100; Chromosome X.
DR Bgee; ENSMFAG00000039559; Expressed in frontal cortex and 3 other cell types or tissues.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR CDD; cd18510; BACK_KLHL4; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR PANTHER; PTHR24412:SF74; KELCH-LIKE PROTEIN 4; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR PRINTS; PR00501; KELCHREPEAT.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 182..249
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 46..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 80688 MW; 362CF9B494A1E4C1 CRC64;
MSVSGKKEFD VKQILRLRWR WFSHPFQGST NTGSCLQQEG YEHRGTPVQG RLKSHSRDRN
GLKKSNSPVH HNILAPVPGP APAHQRAVQN LQQHNLIVHF QANEDTPKAV PEKNLFQEAC
GKRAQDLEMM ADDNIEDSTA RLDTQHSEEM NATGSEEQFH VINHAEQTLR KMENYLKEKQ
LCDVLLIAGH LRIPAHRLVL SAVSDYFAAM FTNDVLEAKQ EEVRMEGVDP NALNSLVQYA
YTGILQLKED TIESLLAAAC LLQLTQVIDV CSNFLIKQLH PSNCLGIRSF GDAQGCTELL
NVAHKYTMEH FIEVIKNQEF LLLPANEISK LLCSDDINVP DEETIFHALM QWVGHDVQNR
QGELGMLLSY IRLPLLPPQL LADLETSSMF TGDLECQKLL MEAMKYHLLP ERRSMMQSPR
TKPRKSTVGA LYAVGGMDAM KGTTTIEKYD LRTNSWLHIG TMNGRRLQFG VAVIDNKLYV
VGGRDGLKTL NTVECFNPVG RIWTVMPPMS THRHGLGVAT LEGPMYAVGG HDGWSYLNTV
ERWDPEGRQW NYVASMSTPR STVGVVALNN KLYAIGGRDG SSCLKSMEYF DPHTNKWSLC
APMSKRRGGV GVATYNGFLY VVGGHDAPAS NHCSRLSDCV ERYDPKSDSW STVAPLSVPR
DAVAVCPLGD KLYVVGGYDG HTYLNTVESY DAQRNEWKEG MQELPQNFYT TQKLKETLGH
//
