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Database: UniProt
Entry: G7WCY4_DESOD
LinkDB: G7WCY4_DESOD
Original site: G7WCY4_DESOD 
ID   G7WCY4_DESOD            Unreviewed;       288 AA.
AC   G7WCY4;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   08-MAY-2019, entry version 39.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:AET66890.1};
GN   OrderedLocusNames=Desor_1224 {ECO:0000313|EMBL:AET66890.1};
OS   Desulfosporosinus orientis (strain ATCC 19365 / DSM 765 / NCIMB 8382 /
OS   VKM B-1628) (Desulfotomaculum orientis).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Peptococcaceae;
OC   Desulfosporosinus.
OX   NCBI_TaxID=768706 {ECO:0000313|EMBL:AET66890.1, ECO:0000313|Proteomes:UP000006346};
RN   [1] {ECO:0000313|Proteomes:UP000006346}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19365 / DSM 765 / NCIMB 8382 / VKM B-1628
RC   {ECO:0000313|Proteomes:UP000006346};
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Ovchinnikova G., Teshima H., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Pester M.,
RA   Spring S., Ollivier B., Rattei T., Klenk H.-P., Wagner M., Loy A.,
RA   Woyke T.;
RT   "Complete sequence of Desulfosporosinus orientis DSM 765.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AET66890.1, ECO:0000313|Proteomes:UP000006346}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19365 / DSM 765 / NCIMB 8382 / VKM B-1628
RC   {ECO:0000313|Proteomes:UP000006346};
RX   PubMed=23105050; DOI=10.1128/JB.01392-12;
RA   Pester M., Brambilla E., Alazard D., Rattei T., Weinmaier T., Han J.,
RA   Lucas S., Lapidus A., Cheng J.F., Goodwin L., Pitluck S., Peters L.,
RA   Ovchinnikova G., Teshima H., Detter J.C., Han C.S., Tapia R.,
RA   Land M.L., Hauser L., Kyrpides N.C., Ivanova N.N., Pagani I.,
RA   Huntmann M., Wei C.L., Davenport K.W., Daligault H., Chain P.S.,
RA   Chen A., Mavromatis K., Markowitz V., Szeto E., Mikhailova N.,
RA   Pati A., Wagner M., Woyke T., Ollivier B., Klenk H.P., Spring S.,
RA   Loy A.;
RT   "Complete genome sequences of Desulfosporosinus orientis DSM765T,
RT   Desulfosporosinus youngiae DSM17734T, Desulfosporosinus meridiei
RT   DSM13257T, and Desulfosporosinus acidiphilus DSM22704T.";
RL   J. Bacteriol. 194:6300-6301(2012).
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DR   EMBL; CP003108; AET66890.1; -; Genomic_DNA.
DR   RefSeq; WP_014183711.1; NC_016584.1.
DR   STRING; 768706.Desor_1224; -.
DR   EnsemblBacteria; AET66890; AET66890; Desor_1224.
DR   KEGG; dor:Desor_1224; -.
DR   PATRIC; fig|768706.3.peg.1206; -.
DR   eggNOG; ENOG4105DYT; Bacteria.
DR   eggNOG; COG1250; LUCA.
DR   KO; K00074; -.
DR   OrthoDB; 862072at2; -.
DR   BioCyc; DORI768706:G1H1K-1200-MONOMER; -.
DR   Proteomes; UP000006346; Chromosome.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   PIRSF; PIRSF000105; HCDH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006346};
KW   NAD {ECO:0000256|PIRSR:PIRSR000105-2};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00324627};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006346}.
FT   DOMAIN        9    186       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      191    287       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   NP_BIND      13     18       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING      36     36       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING      96     96       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     101    101       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     123    123       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     147    147       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   BINDING     279    279       NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
FT   SITE        144    144       Important for catalytic activity.
FT                                {ECO:0000256|PIRSR:PIRSR000105-1}.
SQ   SEQUENCE   288 AA;  31955 MW;  88F6CA58B274F7D8 CRC64;
     MNIEDIKNIC IIGAGNMGHQ IAVCCVLAGY KVTCTDISQE MLAKAEAFAK SYLPERVTKG
     KLSQEQADMA LDNLCFTPSL EEAAGGADYI IEAAVEKMAI KRKLFADLDR IAPPQAILAT
     NSSYIVSSQI ADATKRPDKV CNMHFFNPAL VMKLVEVVQG PHTSEETAQI TMDLCAKLGK
     RAVWLKKEIY GFLVNRILSA LSQEALYLAE MGIATPEEID IAVTNALGHP MGPFRLMDLT
     GIDLTYYRTM ERYQNSRDPK LKPSPLVVER FIKGEWGKKT KKGFYSYE
//
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