ID G7WIM9_DESOD Unreviewed; 1183 AA.
AC G7WIM9;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN OrderedLocusNames=Desor_3625 {ECO:0000313|EMBL:AET69103.1};
OS Desulfosporosinus orientis (strain ATCC 19365 / DSM 765 / NCIMB 8382 / VKM
OS B-1628 / Singapore I) (Desulfotomaculum orientis).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfitobacteriaceae;
OC Desulfosporosinus.
OX NCBI_TaxID=768706 {ECO:0000313|EMBL:AET69103.1, ECO:0000313|Proteomes:UP000006346};
RN [1] {ECO:0000313|Proteomes:UP000006346}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19365 / DSM 765 / NCIMB 8382 / VKM B-1628
RC {ECO:0000313|Proteomes:UP000006346};
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Ovchinnikova G., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Pester M.,
RA Spring S., Ollivier B., Rattei T., Klenk H.-P., Wagner M., Loy A.,
RA Woyke T.;
RT "Complete sequence of Desulfosporosinus orientis DSM 765.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AET69103.1, ECO:0000313|Proteomes:UP000006346}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19365 / DSM 765 / NCIMB 8382 / VKM B-1628
RC {ECO:0000313|Proteomes:UP000006346};
RX PubMed=23105050; DOI=10.1128/JB.01392-12;
RA Pester M., Brambilla E., Alazard D., Rattei T., Weinmaier T., Han J.,
RA Lucas S., Lapidus A., Cheng J.F., Goodwin L., Pitluck S., Peters L.,
RA Ovchinnikova G., Teshima H., Detter J.C., Han C.S., Tapia R., Land M.L.,
RA Hauser L., Kyrpides N.C., Ivanova N.N., Pagani I., Huntmann M., Wei C.L.,
RA Davenport K.W., Daligault H., Chain P.S., Chen A., Mavromatis K.,
RA Markowitz V., Szeto E., Mikhailova N., Pati A., Wagner M., Woyke T.,
RA Ollivier B., Klenk H.P., Spring S., Loy A.;
RT "Complete genome sequences of Desulfosporosinus orientis DSM765T,
RT Desulfosporosinus youngiae DSM17734T, Desulfosporosinus meridiei DSM13257T,
RT and Desulfosporosinus acidiphilus DSM22704T.";
RL J. Bacteriol. 194:6300-6301(2012).
CC -!- FUNCTION: DNA polymerase III is a complex, multichain enzyme
CC responsible for most of the replicative synthesis in bacteria. This DNA
CC polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain
CC is the DNA polymerase. {ECO:0000256|ARBA:ARBA00025611}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBUNIT: DNA polymerase III contains a core (composed of alpha, epsilon
CC and theta chains) that associates with a tau subunit. This core
CC dimerizes to form the POLIII' complex. PolIII' associates with the
CC gamma complex (composed of gamma, delta, delta', psi and chi chains)
CC and with the beta chain to form the complete DNA polymerase III
CC complex. {ECO:0000256|ARBA:ARBA00026073}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE
CC subfamily. {ECO:0000256|ARBA:ARBA00009496}.
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DR EMBL; CP003108; AET69103.1; -; Genomic_DNA.
DR RefSeq; WP_014185911.1; NC_016584.1.
DR AlphaFoldDB; G7WIM9; -.
DR STRING; 768706.Desor_3625; -.
DR KEGG; dor:Desor_3625; -.
DR PATRIC; fig|768706.3.peg.3658; -.
DR eggNOG; COG0587; Bacteria.
DR HOGENOM; CLU_001600_0_0_9; -.
DR Proteomes; UP000006346; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF160975; AF1531-like; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000313|EMBL:AET69103.1};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000006346};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 13..80
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1183 AA; 133020 MW; 163900697BC13ED0 CRC64;
MMADTPKETC GFVHLHNHTE YSLLDGAARI KSLVQRAADL NMPALAITDH GVMYGVIDFY
KACRQAGIKP IIGCEVYVAP HKRTDKAAGK DDANFHLVLL AENEQGYRNL IRLVSMAHIE
GFYYKPRVDK EILRKHSQGL IALSACLAGE VSDHLVHDQL DMAVEKAREY EDIFGKGNFF
LEVQDHGLEE QREVNAGMWK VHERTGIPMV ATNDVHYVQR EDAFVQDALL CIQTGKTLED
ASRMRFSSQE FFLKSEQEMA LLFGEHPELL TNTQQIAQRC QLDFQFGENY LPVFDVPAGY
TLDSFLEAEC RKAFPHFYPQ MTAKEQERLE YELRVIFQTG FSGYFLIVAD FCRYARANGV
AVGPGRGSAA ASMVAYLLGI TSVEPMRFDL LFERFLNPER VSMPDIDIDF DPEGRERVIH
YVTDKYGADK VCQIITFGTM GAKAAIRDVG RVMAIPLYRV DKVAKAIPSD PGMTLEKALE
VSPDLARLID EDEETKRLYT LAKSLEGMPR HASTHAAGIV ISKDSLVNYL PLQRTSEDFV
MTQFPMKTVE EIGLLKMDFL GLRNLTILQE AVQRIEETQG FKLDLHTLAL DDAKTYELLS
SGNSTGIFQL ESGGMRGILK DLKPSCFEDI IAVIALYRPG PMEQIPEFLR RKHGGNITYL
HPKLEPILKS TYGVIVYQEQ VMQIARDLAG YSLGRADLLR RAMGKKKKEI MAEERQNFVH
GLQDSNGEWI IPGALRLGLT LKEAEEIFDL MAKFAEYGFN KGHATAYAVI SYQTAYLKAN
YPLEFMAALL STVMGSSDKI SFYIQDARLS GIEVLPPDVQ YSQVGFSIEK QAIRFGLGAI
RNVGVNVVEK ILEARKEGIF KSLDDFCLRV DQKVLNKRVM ESLIRAGAFS SLCSRNQALK
VMDQVLESTG RRQKDRLSGQ FSLFDFDEGM DEVTVLPQVP DLSEREILDM EKEYLGLYLS
GHPLSSVLPI LKNFISSDIL TCLEGDEEKK VILGGLVTGF RQNVTKKGEM MASFVLEDLT
AGIEVLVFPR VYAQTASLTN DDVIVVTGRY NIRDDEKKIF AEKITKLEDL KPGGENSGGE
NSVAASGSLP DEKIAAYHAP QAVLPKRLFL RFSHESTDIM ENVLKILQRY PGSQPVYFYF
EDTRKVLEGN RSYWVSDQDE LTSALQKVLN QQNVVWQSVK NFA
//