ID   G7WJY9_METH6            Unreviewed;       956 AA.
AC   G7WJY9;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   RecName: Full=Peptidase S8/S53 domain-containing protein {ECO:0000259|Pfam:PF00082};
GN   OrderedLocusNames=Mhar_0037 {ECO:0000313|EMBL:AET63430.1};
OS   Methanothrix harundinacea (strain 6Ac) (Methanosaeta harundinacea).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanotrichales; Methanotrichaceae; Methanothrix.
OX   NCBI_TaxID=1110509 {ECO:0000313|EMBL:AET63430.1, ECO:0000313|Proteomes:UP000005877};
RN   [1] {ECO:0000313|EMBL:AET63430.1, ECO:0000313|Proteomes:UP000005877}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=6Ac {ECO:0000313|EMBL:AET63430.1,
RC   ECO:0000313|Proteomes:UP000005877};
RX   PubMed=22590603; DOI=10.1371/journal.pone.0036756;
RA   Zhu J., Zheng H., Ai G., Zhang G., Liu D., Liu X., Dong X.;
RT   "The genome characteristics and predicted function of methyl-group
RT   oxidation pathway in the obligate aceticlastic methanogens, Methanosaeta
RT   spp.";
RL   PLoS ONE 7:E36756-E36756(2012).
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR   EMBL; CP003117; AET63430.1; -; Genomic_DNA.
DR   RefSeq; WP_014585619.1; NC_017527.1.
DR   AlphaFoldDB; G7WJY9; -.
DR   STRING; 1110509.Mhar_0037; -.
DR   GeneID; 12509206; -.
DR   KEGG; mhi:Mhar_0037; -.
DR   PATRIC; fig|1110509.7.peg.39; -.
DR   HOGENOM; CLU_308524_0_0_2; -.
DR   Proteomes; UP000005877; Chromosome.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.1350.20; -; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR   PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01240};
KW   Protease {ECO:0000256|PROSITE-ProRule:PRU01240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005877};
KW   Serine protease {ECO:0000256|PROSITE-ProRule:PRU01240}.
FT   DOMAIN          494..755
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   ACT_SITE        500
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        544
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        722
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   956 AA;  104400 MW;  000DD60DDB16659B CRC64;
     MKTEGLLIRS ILIIILGLSL GASLEVGLAR EFGGPLTAVR MAGWTIDDGN LTGYGASWAG
     YNESCEEGDL NLSFKLKNLT GEMRVNINID GSNRYSIGFT NTPSLAIDAP AAFVGLIPSA
     DYTLSTFIFK YVGETEAPEK FAGNSIPYDP TKEHQVSIIS REGHIQVYIE RIEEAEKTVI
     REIDGEMMEG KISALQQVID YADPDPLPPG IIDFETLEGA YVELYDLVLT CRPNQPPTVT
     SLGPDPTALR VDRDAIWTAS ASDPEGDPVF YCFWLRGPST GDDWVLQQNW SAEAKWEWRP
     SQRGVYRIGA YATDGRHSAD EIFYSKGSWK DDLVYVEERP LVLGEEDSFQ RPDPEELVDG
     TADGIDWGGK VPINHVLVVV DERFSFEEAT GIAEDLAKGL NGSVVGQFET ILMFQIKTNR
     TTARGDSIEG LIRDIATARE DPSIELAFPN QQIYRESSLS DSVYAEENCK GYEMVRVQES
     WDRVNESGVR LFPVKVAVID DGIYRWENCC EFDNATINTT VGGDAFAPAV LEEPLPGFEI
     AGSHGTGIMN ILAADPDDGG LVGIASQPLG NKLMINLYNI YPPDDNMSFS TDAFLSLKYA
     LENGSTIISC SWGNDRANNA LNVAYKKFFK NISNIAPERL FVCSAGNGGV TTRHSDYKHA
     PGGIEISNMI TVGNVMNDRT PAPDSNQNIK DFFEVTLAAP GAQAVWGRND SGDIKNNSGG
     TSMAAPHVTA AAAMMRSIYP SLEAKDMKDI LRDTGDITPD DPDELVGRVL NIDGSIDNVL
     ENLPETLKDE TRAPLHVEIP RIDGVVTRHT TPKGTNWSLD LTLSDGSGEA KAELKLTQHE
     TVISGNGNLY FLPEEDIDGS ASPRSKCPRD DIFGDVAEAF LGNALPTPSQ QPVEARGSFE
     ETNLQLSIVS LNDMVRYEMT LSVIGSQITG TFKSYDGRGM ARSRGVCYGS LKKEDI
//