ID G7WKR6_METH6 Unreviewed; 1235 AA.
AC G7WKR6;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Anaerobic ribonucleoside-triphosphate reductase {ECO:0000313|EMBL:AET63545.1};
GN OrderedLocusNames=Mhar_0154 {ECO:0000313|EMBL:AET63545.1};
OS Methanothrix harundinacea (strain 6Ac) (Methanosaeta harundinacea).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanotrichales; Methanotrichaceae; Methanothrix.
OX NCBI_TaxID=1110509 {ECO:0000313|EMBL:AET63545.1, ECO:0000313|Proteomes:UP000005877};
RN [1] {ECO:0000313|EMBL:AET63545.1, ECO:0000313|Proteomes:UP000005877}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6Ac {ECO:0000313|EMBL:AET63545.1,
RC ECO:0000313|Proteomes:UP000005877};
RX PubMed=22590603; DOI=10.1371/journal.pone.0036756;
RA Zhu J., Zheng H., Ai G., Zhang G., Liu D., Liu X., Dong X.;
RT "The genome characteristics and predicted function of methyl-group
RT oxidation pathway in the obligate aceticlastic methanogens, Methanosaeta
RT spp.";
RL PLoS ONE 7:E36756-E36756(2012).
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DR EMBL; CP003117; AET63545.1; -; Genomic_DNA.
DR AlphaFoldDB; G7WKR6; -.
DR STRING; 1110509.Mhar_0154; -.
DR KEGG; mhi:Mhar_0154; -.
DR PATRIC; fig|1110509.7.peg.168; -.
DR HOGENOM; CLU_002707_0_0_2; -.
DR Proteomes; UP000005877; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0008998; F:ribonucleoside-triphosphate reductase activity; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR CDD; cd00081; Hint; 1.
DR Gene3D; 3.20.70.20; -; 2.
DR Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 1.
DR Gene3D; 3.10.28.10; Homing endonucleases; 1.
DR InterPro; IPR005144; ATP-cone_dom.
DR InterPro; IPR003586; Hint_dom_C.
DR InterPro; IPR003587; Hint_dom_N.
DR InterPro; IPR036844; Hint_dom_sf.
DR InterPro; IPR027434; Homing_endonucl.
DR InterPro; IPR006142; INTEIN.
DR InterPro; IPR004042; Intein_endonuc.
DR InterPro; IPR006141; Intein_N.
DR InterPro; IPR012833; NrdD.
DR NCBIfam; TIGR01445; intein_Nterm; 1.
DR PANTHER; PTHR21075; ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE; 1.
DR PANTHER; PTHR21075:SF0; ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE; 1.
DR Pfam; PF14890; Intein_splicing; 1.
DR Pfam; PF13597; NRDD; 2.
DR PRINTS; PR00379; INTEIN.
DR SMART; SM00305; HintC; 1.
DR SMART; SM00306; HintN; 1.
DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR SUPFAM; SSF55608; Homing endonucleases; 1.
DR SUPFAM; SSF51998; PFL-like glycyl radical enzymes; 2.
DR PROSITE; PS51161; ATP_CONE; 1.
DR PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
DR PROSITE; PS50817; INTEIN_N_TER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00492}; Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00492}; Protein splicing {ECO:0000256|ARBA:ARBA00023000};
KW Reference proteome {ECO:0000313|Proteomes:UP000005877}.
FT DOMAIN 24..119
FT /note="ATP-cone"
FT /evidence="ECO:0000259|PROSITE:PS51161"
FT DOMAIN 595..741
FT /note="DOD-type homing endonuclease"
FT /evidence="ECO:0000259|PROSITE:PS50819"
SQ SEQUENCE 1235 AA; 139212 MW; 01B22842B0EF2486 CRC64;
MSRRVNGYKS QQITLEGVSL SEMPMVRTTD GHLMRWNRDA VVKQLLRETK LSEQFYRIPG
ISEEEAAEIA REVERRIRWM DVKFLSGPLV REIVNVILLE RHHLEWRNIC TRVGTPVYDA
HLIDVGSGFE AHENANLQEN AETSHKKKAD KISKEQYLLL IPPYLSDHHL AGDLHIHDLE
YFGTRPFCQD WDLRYFFYYG LMPDGSGTKA SVAGPAKKPE VAMLHAVKAL ASAQTNFAGG
QGFYNFLTFL APYLEGLDYS EICQLMQMFV YEMTQMMVAR GGQVVFSSVQ LSPGVPKLWR
DKPVVYQGKV WDGEGAPLRT YGEFEKEVRL GFKALMEVML EGDYWGKPFN FPKPEISIEP
DFMAEDDGFN AAHPEVPTYR DLYLLSFQLA SKFGTPYYDN QLPAYRGAGK GISCYQCLAE
DELVSLADPE GQIHVKQISE IFSEAEEYGK ETDPFGVEFV RFQGRTPSVN FDTLEASLRE
FKGVMRQRCE GELLKIVLKS GRRIRVTPNH PVYVLDKGNF VKKQACDLNV GDFLPLLTDV
DFGLAPLASI DVETTLLKAG YADEIVVHNE SVNVKNAKKP GLPKNISITS ELVRFLGYYL
AEGCSDQSGR RYSVRLSFGK HESGLIDDAM ACIKSLGLEP KVSEEKTATN VVVNSKLLYL
LIDALGCGHD AHTKSVPDLL FNVDPSLVGE YICCAFRGDG NVNVQKGELN GRPHTAHVIR
IGLVSRDAVQ RLIWLAQRIG VQMNYMVRDE TVRHPQTGNP YRLTSYSCYV TSQDQIENFY
SRTGYGGCAV SDDRKEVGGV FTRIPIENAG LEHADLKYPS QYRSQGHKCV NQRHIDSSGS
PIIERLIGGD VHVLEIREIE VEEYGGYVYD LVDVSETHNF SNAMGIVTGN CCAYQFAATF
ESDAAFEDKL LFKEGMHFSM GSWQVVSLNC PRAAYLARGD DDLLFEYLRG LMDTAVEIFK
VKREWMNQVI KNRRMPFATQ RPKDPRTGKK GTLAVDLESL VYTIGVVGVN EMVQFHTGSQ
MHESKEAWKL AVRAMTEMEI YAKELSRRHG MTIALARTPA ETVVQRFAVS DLLSEKFRDC
AARVVKGDLD TAMKRIHQTR DLPVYYTNGT HIPPSLDVSI FERAKLEHIF FPIVDGGNIF
HIFLGESAPD PQGLMDFAMN LARSTQIGYF AFTRDMTVCL SCFCVSPGLK EECPRCGSDH
LEYLSRVTGY LQSVSGWNEA KKQELRDRNK YSDLS
//
