ID G7WLI3_METH6 Unreviewed; 575 AA.
AC G7WLI3;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Chloride transporter, chloride channel (ClC) family protein {ECO:0000313|EMBL:AET64286.1};
GN OrderedLocusNames=Mhar_0915 {ECO:0000313|EMBL:AET64286.1};
OS Methanothrix harundinacea (strain 6Ac) (Methanosaeta harundinacea).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanotrichales; Methanotrichaceae; Methanothrix.
OX NCBI_TaxID=1110509 {ECO:0000313|EMBL:AET64286.1, ECO:0000313|Proteomes:UP000005877};
RN [1] {ECO:0000313|EMBL:AET64286.1, ECO:0000313|Proteomes:UP000005877}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6Ac {ECO:0000313|EMBL:AET64286.1,
RC ECO:0000313|Proteomes:UP000005877};
RX PubMed=22590603; DOI=10.1371/journal.pone.0036756;
RA Zhu J., Zheng H., Ai G., Zhang G., Liu D., Liu X., Dong X.;
RT "The genome characteristics and predicted function of methyl-group
RT oxidation pathway in the obligate aceticlastic methanogens, Methanosaeta
RT spp.";
RL PLoS ONE 7:E36756-E36756(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP003117; AET64286.1; -; Genomic_DNA.
DR AlphaFoldDB; G7WLI3; -.
DR STRING; 1110509.Mhar_0915; -.
DR KEGG; mhi:Mhar_0915; -.
DR PATRIC; fig|1110509.7.peg.1024; -.
DR HOGENOM; CLU_015263_5_1_2; -.
DR OrthoDB; 89900at2157; -.
DR Proteomes; UP000005877; Chromosome.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd00400; Voltage_gated_ClC; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR43427; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR PANTHER; PTHR43427:SF6; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 2.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW Reference proteome {ECO:0000313|Proteomes:UP000005877};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 449..505
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 511..570
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 575 AA; 59352 MW; 368718BD0E064C39 CRC64;
MIRSWGENRW LVLDALAVGT GLLGGLGAVV FRWLAGEVQG LFFGPVATLL PGGGEALLPV
LGGLAVGLLI LRFAPEARGE GIPALMVALH KRGGRVRRRT GPAILIASAI TIGSGGSAGR
ESPIAQIGAS FGSLLGQRLR LDVADVQILA VSGFVAGLAG TFNAPLGSAI FGMEVVMRRF
RMVDAVPILL SAVVGAATAS AFLGQSPAFT PVWTEITLPE LLLCFLMGLT FGGLAILWAG
LLSRAERLFL WLPLKEGLKP GLGGLVAGAA GVYFIGYGVM GVGYDGVDRI LAIASDPAGS
DGSRLVLFLL ALAAAKALAT ASTLGSGGCG GTIGPTLVIG AVAGASFGLL FGHLVPAAGG
HAPAYALLGA AALLAGSAGA PLASVVLISE MAADYSLLPA LMITSAASYA VASIGLSGST
IFTFQLLRRG VTLDGGEALL ERVLVRDAMT REVVALGPET TVREAMARIF EENVRGFPVV
EGGRLAGIVT FDDLRRVPEG KQDEVRVGEV AVKDVIVAFP DENMKNVMDR LYRNNVGRLP
VMEREDPKKV VGIVTRTDAI AAYQVLSREE AGRER
//
