ID   FILR2_METH6             Reviewed;         155 AA.
AC   G7WMP8;
DT   24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=Probable methanogenesis regulatory protein FilR2 {ECO:0000305};
GN   Name=filR2 {ECO:0000303|PubMed:24748383};
GN   OrderedLocusNames=Mhar_0447 {ECO:0000312|EMBL:AET63832.1};
OS   Methanothrix harundinacea (strain 6Ac) (Methanosaeta harundinacea).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanotrichales; Methanotrichaceae; Methanothrix.
OX   NCBI_TaxID=1110509;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=6Ac;
RX   PubMed=22590603; DOI=10.1371/journal.pone.0036756;
RA   Zhu J., Zheng H., Ai G., Zhang G., Liu D., Liu X., Dong X.;
RT   "The genome characteristics and predicted function of methyl-group
RT   oxidation pathway in the obligate aceticlastic methanogens, Methanosaeta
RT   spp.";
RL   PLoS ONE 7:E36756-E36756(2012).
RN   [2]
RP   FUNCTION, INDUCTION, AND PHOSPHORYLATION.
RC   STRAIN=6Ac;
RX   PubMed=24748383; DOI=10.1371/journal.pone.0095502;
RA   Li J., Zheng X., Guo X., Qi L., Dong X.;
RT   "Characterization of an archaeal two-component system that regulates
RT   methanogenesis in Methanosaeta harundinacea.";
RL   PLoS ONE 9:E95502-E95502(2014).
CC   -!- FUNCTION: Member of the two-component regulatory system FilI/FilRs,
CC       which is involved in the regulation of methanogenesis.
CC       {ECO:0000269|PubMed:24748383}.
CC   -!- INDUCTION: Transcriptionally regulated by FilR1.
CC       {ECO:0000269|PubMed:24748383}.
CC   -!- PTM: Phosphorylated by FilI. {ECO:0000269|PubMed:24748383}.
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DR   EMBL; CP003117; AET63832.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7WMP8; -.
DR   SMR; G7WMP8; -.
DR   STRING; 1110509.Mhar_0447; -.
DR   KEGG; mhi:Mhar_0447; -.
DR   PATRIC; fig|1110509.7.peg.499; -.
DR   HOGENOM; CLU_000445_69_17_2; -.
DR   Proteomes; UP000005877; Chromosome.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   CDD; cd17557; REC_Rcp-like; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   PANTHER; PTHR44520; RESPONSE REGULATOR RCP1-RELATED; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; CheY-like; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..155
FT                   /note="Probable methanogenesis regulatory protein FilR2"
FT                   /id="PRO_0000433372"
FT   DOMAIN          18..142
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   MOD_RES         75
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   155 AA;  17705 MW;  A15C5AA5B70A3E29 CRC64;
     MSYGLDSGDV LEAEDPFIIL LVEDNNAHAM LIMRAFERLG FTGRIEWLRD GKAALDYLRL
     HEGGGRSLPR MVLLDLRLPK VDGHEVLSQI KRSERLRAIP VVVLTTSTSD DDLRRAYSNH
     VNSYLIKPLS FEDLKRTVEE IKEYWLGWNR SPGPA
//