ID G7WQC8_METH6 Unreviewed; 619 AA.
AC G7WQC8;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Chaperone protein DnaK {ECO:0000256|HAMAP-Rule:MF_00332};
DE AltName: Full=HSP70 {ECO:0000256|HAMAP-Rule:MF_00332};
DE AltName: Full=Heat shock 70 kDa protein {ECO:0000256|HAMAP-Rule:MF_00332};
DE AltName: Full=Heat shock protein 70 {ECO:0000256|HAMAP-Rule:MF_00332};
GN Name=dnaK {ECO:0000256|HAMAP-Rule:MF_00332};
GN OrderedLocusNames=Mhar_2126 {ECO:0000313|EMBL:AET65481.1};
OS Methanothrix harundinacea (strain 6Ac) (Methanosaeta harundinacea).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanotrichales; Methanotrichaceae; Methanothrix.
OX NCBI_TaxID=1110509 {ECO:0000313|EMBL:AET65481.1, ECO:0000313|Proteomes:UP000005877};
RN [1] {ECO:0000313|EMBL:AET65481.1, ECO:0000313|Proteomes:UP000005877}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6Ac {ECO:0000313|EMBL:AET65481.1,
RC ECO:0000313|Proteomes:UP000005877};
RX PubMed=22590603; DOI=10.1371/journal.pone.0036756;
RA Zhu J., Zheng H., Ai G., Zhang G., Liu D., Liu X., Dong X.;
RT "The genome characteristics and predicted function of methyl-group
RT oxidation pathway in the obligate aceticlastic methanogens, Methanosaeta
RT spp.";
RL PLoS ONE 7:E36756-E36756(2012).
CC -!- FUNCTION: Acts as a chaperone. {ECO:0000256|HAMAP-Rule:MF_00332}.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|HAMAP-Rule:MF_00332, ECO:0000256|RuleBase:RU003322}.
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DR EMBL; CP003117; AET65481.1; -; Genomic_DNA.
DR RefSeq; WP_014587657.1; NC_017527.1.
DR AlphaFoldDB; G7WQC8; -.
DR STRING; 1110509.Mhar_2126; -.
DR GeneID; 12511300; -.
DR KEGG; mhi:Mhar_2126; -.
DR PATRIC; fig|1110509.7.peg.2359; -.
DR HOGENOM; CLU_005965_2_4_2; -.
DR OrthoDB; 9944at2157; -.
DR Proteomes; UP000005877; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR HAMAP; MF_00332; DnaK; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR012725; Chaperone_DnaK.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR NCBIfam; TIGR02350; prok_dnaK; 1.
DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR PANTHER; PTHR19375:SF184; STRESS-70 PROTEIN, MITOCHONDRIAL; 1.
DR Pfam; PF00012; HSP70; 2.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 1.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00332}; Chaperone {ECO:0000256|HAMAP-Rule:MF_00332};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00332}; Reference proteome {ECO:0000313|Proteomes:UP000005877}.
FT REGION 582..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 619 AA; 67065 MW; DB23A3D105F8CD02 CRC64;
MSKIIGIDLG TSNSAAAVLI GGKPTMIPSA EGTSIVAGGK AFPSYVAFTK DGQRLVGEPA
RRQAATNPEG TITGIKRKMG QDYRVEVYGK SYTPQDISSF ILRKIKDDSE AFLGEKVEKA
VITVPAYFND NQRQATKDAG TIAGLDVVRI INEPTAAALA YGMDKEGEAT LMVFDLGGGT
LDVTIMEAGE GVFEVKSTSG DTQLGGRDMD EILTNYVVER YRQESGIDLK GDRMAMQRLR
EAVEIAKIEL SSVLQTTINL PYITADQTGP KHLEMTITRA KLEELIKEVL ERCRNPMIQA
IRDAKLDKSG IDKIVLVGGP TRMPAVRKFV TEFMGKEPEG GVDPMECVAI GAAVQGGVLG
GEVKDILLLD VTPLSLGIET LGGVATKLIE RNTTIPTRKS QIFTTAADNQ TTVEIHVLQG
ERPLAKDNTS LGRFTLSGIP PAPRGIPQIE VAFDIDANGI LNVSAKDLAT GKEQAITISA
PHKLSQNEIE RKIREAEQHA YEDTRRKEEI EAKNQAETLV YTAEKTLKDA GEVVTADQKE
KIERAIGEAK EALAGGDIAK IKEKTEALQN AIYELSTAMY QRAAEQQQRE QEKQQQSQGG
PTASGETIDA DFEVVNDKR
//
