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Database: UniProt
Entry: G7X4R5_ASPKW
LinkDB: G7X4R5_ASPKW
Original site: G7X4R5_ASPKW 
ID   G7X4R5_ASPKW            Unreviewed;       998 AA.
AC   G7X4R5;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   13-FEB-2019, entry version 38.
DE   SubName: Full=Lactase B {ECO:0000313|EMBL:GAA82087.1};
GN   ORFNames=AKAW_00202 {ECO:0000313|EMBL:GAA82087.1};
OS   Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus
OS   awamori var. kawachi).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1033177 {ECO:0000313|EMBL:GAA82087.1, ECO:0000313|Proteomes:UP000006812};
RN   [1] {ECO:0000313|EMBL:GAA82087.1, ECO:0000313|Proteomes:UP000006812}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 4308 {ECO:0000313|Proteomes:UP000006812};
RX   PubMed=22045919; DOI=10.1128/EC.05224-11;
RA   Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y.,
RA   Takashita H., Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.;
RT   "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308,
RT   used for brewing the Japanese distilled spirit shochu.";
RL   Eukaryot. Cell 10:1586-1587(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing beta-D-galactose
CC         residues in beta-D-galactosides.; EC=3.2.1.23;
CC         Evidence={ECO:0000256|SAAS:SAAS01116863};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|RuleBase:RU003679, ECO:0000256|SAAS:SAAS00534244}.
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DR   EMBL; DF126447; GAA82087.1; -; Genomic_DNA.
DR   InParanoid; G7X4R5; -.
DR   Proteomes; UP000006812; Unassembled WGS sequence.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.102.20.10; -; 1.
DR   Gene3D; 2.60.120.260; -; 2.
DR   Gene3D; 2.60.390.10; -; 1.
DR   InterPro; IPR018954; Betagal_dom2.
DR   InterPro; IPR037110; Betagal_dom2_sf.
DR   InterPro; IPR025972; BetaGal_dom3.
DR   InterPro; IPR036833; BetaGal_dom3_sf.
DR   InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; PTHR23421; 1.
DR   Pfam; PF10435; BetaGal_dom2; 1.
DR   Pfam; PF13363; BetaGal_dom3; 1.
DR   Pfam; PF13364; BetaGal_dom4_5; 2.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SMART; SM01029; BetaGal_dom2; 1.
DR   SUPFAM; SSF117100; SSF117100; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006812};
KW   Glycosidase {ECO:0000256|SAAS:SAAS00108888};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00108869};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006812};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    998       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003505257.
FT   DOMAIN      385    567       BetaGal_dom2. {ECO:0000259|SMART:
FT                                SM01029}.
SQ   SEQUENCE   998 AA;  109342 MW;  50928EC4D04E0C66 CRC64;
     MTRITKLCAL LLSSTGLLAA AQNQTETGWP LYDDGLTTDI QWDHYSFKVH VPGLWRDILE
     KIKAAGFTTF SIYSSWAWHA PNNHTVDFST GARDITPIFE LAKELGMYII VRPGPYINAE
     ASAGGFPLWL TTGDYGTLRN NDSRYTAAWK PYFEKMTEIT SRYQVTNGHN TFCYQIENEY
     GDQWLSDPSE RVPNETAIAY MELLESSARE NGILVPFTAN DPNMNAMAWS RDWSNAGGNV
     DVVGLDSYPS CWTCDVSQCT STNGEYVAYQ VVEYYDYFLE FSPTMPSFMP EFQGGSYNPW
     AGPEGGCGDD TGVDFVNLFY RWNIAQRVTA MSLYMLYGGT NWGAIAAPVT ATSYDYSSPI
     SEDRSISSKY YETKLLSLFT RSARDLTMTD LIGNGTQYTN NTAVKAYELR NPTTNAGFYV
     TLHEDSTVGT NEAFSLRVNT SAGNLIVPRL GGSIRLNGHQ SKIIVTDFTF GSETLLYSTA
     EVLTYAVLDK KPTLVLWVPT GESGEFAVKG AKSGSVVSKC QDCSAINFHQ QGGNLVVGFT
     QAQGMSIVQI DNDIRVILLD RTAAYEFWAP ALTEDPLVPE DEAVLIQGPY LVRSASLEKS
     TLAIKGDSIN ETAVEIFAPN DVKTVTWNGK QLKTSKSSYG SLKATIAAPV SIQLPAFTSW
     KVNDSLPERL PTYDASGLAW VDANHMTTAN PSKPATLPVL YADEYGFHNG VRLWRGYFNG
     TASGVFLNVQ GGSAFGFSAY LNGQFLGSYL GNASIEQANQ TFVFPTNITH PTTQNTLLII
     HDDTGHDETT GALNPRGILE ARLLPSTTTD NTASPEFTHW RLAGTAGGES NLDPVRGAWN
     EDGLYAERVG WHLPGFDDST WPSVSSSSLS FTGATVKFFR TTIPLNIPRG LDVSISFVLG
     TPDNAPNTYR AQLFVNGYQY GRFNPYIGNQ VVFPVPVGVL DYSGENTIGV AVWAQTEDGA
     AITVDWKVNY VADSSLDVAG LETAGLRPGW SVERLKFA
//
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