ID G7X824_ASPKW Unreviewed; 789 AA.
AC G7X824;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=ADAM family of metalloprotease ADM-B {ECO:0000313|EMBL:GAA82952.1};
GN ORFNames=AKAW_01067 {ECO:0000313|EMBL:GAA82952.1};
OS Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus
OS awamori var. kawachi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1033177 {ECO:0000313|EMBL:GAA82952.1};
RN [1] {ECO:0000313|EMBL:GAA82952.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFO 4308 {ECO:0000313|EMBL:GAA82952.1};
RX PubMed=22045919; DOI=10.1128/EC.05224-11;
RA Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H.,
RA Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.;
RT "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used
RT for brewing the Japanese distilled spirit shochu.";
RL Eukaryot. Cell 10:1586-1587(2011).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
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DR EMBL; DF126448; GAA82952.1; -; Genomic_DNA.
DR AlphaFoldDB; G7X824; -.
DR STRING; 1033177.G7X824; -.
DR VEuPathDB; FungiDB:AKAW_01067; -.
DR eggNOG; KOG3607; Eukaryota.
DR InParanoid; G7X824; -.
DR Proteomes; UP000006812; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04271; ZnMc_ADAM_fungal; 1.
DR Gene3D; 3.40.1620.60; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR InterPro; IPR006586; ADAM_Cys-rich.
DR InterPro; IPR041645; ADAMTS_CR_2.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR InterPro; IPR034028; ZnMc_ADAM_fungal.
DR PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR PANTHER; PTHR11905:SF159; MIND-MELD, ISOFORM J; 1.
DR Pfam; PF17771; ADAMTS_CR_2; 1.
DR Pfam; PF00200; Disintegrin; 1.
DR Pfam; PF13688; Reprolysin_5; 1.
DR SMART; SM00608; ACR; 1.
DR SMART; SM00050; DISIN; 1.
DR SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00023049, ECO:0000313|EMBL:GAA82952.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000313|EMBL:GAA82952.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:GAA82952.1};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..789
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003505234"
FT TRANSMEM 700..721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 275..487
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT DOMAIN 512..601
FT /note="Disintegrin"
FT /evidence="ECO:0000259|PROSITE:PS50214"
FT REGION 738..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 738..756
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 426
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 425
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 429
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 435
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
SQ SEQUENCE 789 AA; 84142 MW; 4AF365632E42550B CRC64;
MRFLTYSLPF IASAISLFGA SVQARSQAPS AIRHVSTLDQ PTIKTPSQRV DHLDHFDITF
DIHDTHQRIK LELEPNHDIL AEDASVQYLD ADGNVRRHEP IARHEHKVFK GRSLLGRGKG
MWDPVGWARI YLKQDGSEPL FEGVFSVDGD NHHVQLKSAY MEKKRPVDVD LPDSAKDYMI
FYRDSDMVRL HTELKRSSLG STSCQADQLG FNTNPNHPVL QPYVQAETDA WGAMSLNSLF
GLNKRQSDIG SVSGNAGGVN LASTIGDTSG CPSTKQVALI GVATDCSFTG SFNNETAAKE
WVISTVNSAS NVYEKSFNIT IGLRNLTITD SSCPDNPPAA TAWNMPCSSG NLTSRLDLFS
KWRGEQSDDN AYWTLMSDCA TGNEVGLSWL GQLCNSDASS DGSSTVSGTN VVVRSSGSDW
QIFAHESGHT FGAVHDCDSQ TCAQDLEASS QCCPLTSSTC DANAKYIMNP TTGTDITSFS
QCTIGNICAA LGRNSVKSSC LSANRDVTTY TGSQCGNGIV ESGEDCDCGG EDGCGDNNCC
DAKTCKFKSG AVCDDSNDSC CSSCQFSSAG TVCRASRGDC DVAETCSGNS STCPTDSFKK
DGTSCGSSGS GLACASGQCT SRDYQCRSVM GSLLHSNDTY ACSSFSSSCE LVCTSPKIGT
CYSVNQNFLD GTPCGSGGYC SNGDCKGQNV ESWIKNHKGI VIGVACAVGA LILLALMTCI
VNRCRQARAP KPVPRPVPYG PWPGARPPPP PPMNQWPARG YQGLGNEPPP PYPGVAGQPQ
YMSPQGRYA
//
