ID G7X8W8_ASPKW Unreviewed; 734 AA.
AC G7X8W8;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE SubName: Full=DNA mismatch repair protein Mlh1 {ECO:0000313|EMBL:GAA83324.1};
GN ORFNames=AKAW_01439 {ECO:0000313|EMBL:GAA83324.1};
OS Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus
OS awamori var. kawachi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1033177 {ECO:0000313|EMBL:GAA83324.1};
RN [1] {ECO:0000313|EMBL:GAA83324.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFO 4308 {ECO:0000313|EMBL:GAA83324.1};
RX PubMed=22045919; DOI=10.1128/EC.05224-11;
RA Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H.,
RA Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.;
RT "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used
RT for brewing the Japanese distilled spirit shochu.";
RL Eukaryot. Cell 10:1586-1587(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; DF126449; GAA83324.1; -; Genomic_DNA.
DR AlphaFoldDB; G7X8W8; -.
DR STRING; 1033177.G7X8W8; -.
DR VEuPathDB; FungiDB:AKAW_01439; -.
DR eggNOG; KOG1979; Eukaryota.
DR InParanoid; G7X8W8; -.
DR Proteomes; UP000006812; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03483; MutL_Trans_MLH1; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 246..365
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 734 AA; 81558 MW; 6F6EA581B57E24E8 CRC64;
MDPQMDLDHT EPRGTKRSAE DNEEPQRPKR IRALDPDVVN KIAAGEIIVA PMHALKELIE
NAVDAGSTSI EILVKDGGLK LLQITDNGHG IDRDDLPILC ERFTTSKLKQ FEDLSSIGTY
GFRGEALASI SHIAHLTVTT KTAGSSCAWR AHYSDGKLVP PKPGQSAAPK ATAGRGGTQI
TVEDLFYNVP TRRRAFRSAS EEYAKILDVV GRYSVHCSGV AFSCRKHGDS GVSVSTPAAA
NTIDRIRQIH GSAVANELVE FSVEDDKLGF RSSGFATNAN YHVKRTTILL FINHRSVEST
AIKRAVEQTY SSFLPKGGHP FAYIDLEIEP QRVDVNVHPT KREVNFLNED EIIECICNEI
RSKLAQVDSS RTFLTQTLLP GVTTMEPANR DAEGSTDTVP KTPSTTRKPY EHNLVRTDSK
VRKITSMLTP ATPHTPTASQ ADTTTILDEG LQYETTSREP HRISFTSVKN LRASVRNAMH
NTLTETIASH TYVGLVDERR RIAAIQSGVK LYLIDYGMFC TEFFYQIGLT DFANFGVIKL
SPPPKLIDLL RIAADTERTQ SSQESTAAEE ANEIFTNAPD LVAETLIDRR EMLNEYFSLE
ISPDGDLLSI PLLLKGYLPS LGKLPRFLLR LGPYVDWTSE EECFRTFLRE LAAFYTPEQL
PPPPNVQKSN DAGAEGEVEM EDEFITQRRA QMARMLEHVV FPALRARMVA TTRLLKGVVE
VADLKGLYRV FERC
//
