ID G7XF46_ASPKW Unreviewed; 406 AA.
AC G7XF46;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Glycosyl hydrolase family 43 protein {ECO:0000313|EMBL:GAA85193.1};
GN ORFNames=AKAW_03307 {ECO:0000313|EMBL:GAA85193.1};
OS Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus
OS awamori var. kawachi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1033177 {ECO:0000313|EMBL:GAA85193.1};
RN [1] {ECO:0000313|EMBL:GAA85193.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFO 4308 {ECO:0000313|EMBL:GAA85193.1};
RX PubMed=22045919; DOI=10.1128/EC.05224-11;
RA Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H.,
RA Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.;
RT "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used
RT for brewing the Japanese distilled spirit shochu.";
RL Eukaryot. Cell 10:1586-1587(2011).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865, ECO:0000256|RuleBase:RU361187}.
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DR EMBL; DF126453; GAA85193.1; -; Genomic_DNA.
DR AlphaFoldDB; G7XF46; -.
DR SMR; G7XF46; -.
DR STRING; 1033177.G7XF46; -.
DR VEuPathDB; FungiDB:AKAW_03307; -.
DR eggNOG; ENOG502S9PF; Eukaryota.
DR InParanoid; G7XF46; -.
DR Proteomes; UP000006812; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd08999; GH43_ABN-like; 1.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR PANTHER; PTHR42812; BETA-XYLOSIDASE; 1.
DR PANTHER; PTHR42812:SF5; ENDO-ARABINASE; 1.
DR Pfam; PF04616; Glyco_hydro_43; 1.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|RuleBase:RU361187};
KW Hydrolase {ECO:0000256|RuleBase:RU361187, ECO:0000313|EMBL:GAA85193.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 62..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 114
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT ACT_SITE 306
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT SITE 235
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 406 AA; 44195 MW; C738086E0A4326CD CRC64;
MKGLPSLLNG SSTRKWTQST PSTDTAEDEG QSGSTISPTK PPSADISSGG SKNPMIWTRR
KITWLITLIA LSVAIIVVVI TVPVVLLVDD AHNDDPSYYN SANRPVRVVQ DFPDPGLIQV
NSTWYAYATV ATPDNPDVPH VPVSTSRNFS SWDWLQGHDV MPAMSSWETN MNQYAPDVIQ
RKDGRFVLYY SGELKDWLRH HCVGAAVSNS TSPLGPYIPH NSTLACPRDH GGAIDPAPFK
DVNGTLYVVY KVDGNSVGHG GDCNNGKKPI VSTPIMLQQL NDDGVTPVGD PVQILTNEKV
DGPLVEAPNI IRTDRGIYYL FFSSHCYTSS KYSVKYAWST SLKGPYTRAE RPLFRTGDFG
LKSPGGATAS IDGSKIVFHA FCGDYRCMFA AAMNITANYT ILPAAL
//
