ID G7XKF9_ASPKW Unreviewed; 1796 AA.
AC G7XKF9;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN ORFNames=AKAW_05571 {ECO:0000313|EMBL:GAA87457.1};
OS Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus
OS awamori var. kawachi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1033177 {ECO:0000313|EMBL:GAA87457.1};
RN [1] {ECO:0000313|EMBL:GAA87457.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFO 4308 {ECO:0000313|EMBL:GAA87457.1};
RX PubMed=22045919; DOI=10.1128/EC.05224-11;
RA Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H.,
RA Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.;
RT "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used
RT for brewing the Japanese distilled spirit shochu.";
RL Eukaryot. Cell 10:1586-1587(2011).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550,
CC ECO:0000256|RuleBase:RU004279};
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|RuleBase:RU004279}.
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DR EMBL; DF126459; GAA87457.1; -; Genomic_DNA.
DR STRING; 1033177.G7XKF9; -.
DR VEuPathDB; FungiDB:AKAW_05571; -.
DR eggNOG; KOG0262; Eukaryota.
DR InParanoid; G7XKF9; -.
DR Proteomes; UP000006812; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd02735; RNAP_I_Rpa1_C; 1.
DR CDD; cd01435; RNAP_I_RPA1_N; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.150.390; -; 1.
DR Gene3D; 1.10.357.120; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.30.70.2850; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR047107; DNA-dir_RNA_pol1_lsu_C.
DR InterPro; IPR015699; DNA-dir_RNA_pol1_lsu_N.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF11; DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 480..807
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1476..1580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1525..1551
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1796 AA; 199227 MW; 4EAC4B173032C61A CRC64;
MNAPLTHGDQ QSDRQASDGI EVRESKKGSF ISKIWGRSRK DVNNRDKERI SNHGALQVPT
WVRRRCRTAE KKLGETFRIV DTDEPAFSAS QAFNPPRVPE FAPPASFVAQ AAARGIMTTF
ARPVASSIAG IEFGVYNDQD IKAISVKRIH NTPTLDSFNN PVPGGLYDPA MGAWGDHVCT
TCRQTSWSCT GHPGHIELPV HVYNVTHFDQ LYRLLKGQCV YCHRFQMSRT NINSYSCKLR
LLHYGLVDEV AVIDTIGGKG SDKKKANKDG EGSSSEEEDD DDIIARRNAF VKKSIRQAQA
DGRLRGLMSG SKNPLAAEQR RALVREFFKD IGAVKKCASC SGLSPSYRKD RSSKIFRKAL
PEKSRLTMTQ AGFQIPNSLV LLQQAKKLTS KEKAALANGV SDNVSTTSET HGAEEEVARG
NAIVAQAESR KQAVGETQQF MPSPEVHAAM TLLFEKEQEI LSLVYNSRPL PKKESQVSAD
MFFIKNILVP PNKFRPAAPQ GPGQIMEAQQ NQSFTAILKN CDIINQISKE RQSAGADSTT
RVRDYRDLLH SIVTLQDTVN MLIDRDRGNL SGPAAAAAPM GIKQYLEKKE GLFRKNMMGK
RVNFAARSVI SPDPNIETNE IGVPMVFAKK LTYPEPVTNH NFWEMKQAVI NGPDKYPGAS
AIENEFGQVT NLRFKSLDER TALANQLLAP SNWRMKGSRN KKVYRHLTTG DIVLMNRQPT
LHKPSIMGHK ARVLPNERTI RMHYANCNTY NADFDGDEMN MHFPQNELAR SEAMMLADAD
HQYLVATSGK PLRGLIQDHI SMGTWFTCRD SFFDEEEYYQ LLYSCLRPEN SHTITDRIQT
VGPTVIRPKR LWTGKQIIST ILKNIMPSDR AGLNLKSKSS TPGDRWGEGN EEGEVIFKDG
EMLCGILDKK QIGPTAGGLI DAIHEIYGHT IAGRLISILG RLLTRYLNMR AFTCGIDDLR
LTPEGDRVRK EKISEAAAIG REVALKYVTL DQTTVPDQDA ELRRRMEEVL RDDEKQGGLD
SVSNARTAKL STEITKACLP KGLVKPFPWN QMQSMTISGA KGSSVNANLI SCNLGQQVLE
GRRVPVMVSG KTLPSFRAFD TNPMAGGYVC GRFLTGIKPQ EYYFHAMAGR EGLIDTAVKT
SRSGYLQRCL IKGMEGLKAE YDSSVREATD GSIVQFLYGE DGLDITKQVH LKDFDFLASN
YVSIMSQVNL TSDFHNLEKE EVANWHKDAM KKVRKTGKVE AMDPVLSLYH PGGNLGSISE
NFSQALKKYE DANPDKLLKD KKKDVNGIIS KKAFNTLMNM KYMKSVVEPG EAIGIVAGQS
IGEPSTQMTL NTFHLAGHSA KNVTLGIPRL REIVMTASAH IMTPTMTLIL NDELSKEHSE
RFAKAISKLS IAEVVDKVQV RERVSSGSVK AKVYDIDITF FPADEYTAEY AITTKDVQNT
LQKKLIPKLV KLTKAELKKR VDEKTLKKYS TAQPEIGASV GTVQDGPRGA DADAEPADDD
VEDDEDDAKR ARGTQNRSNQ VSYEGPEDEE VDMVRQQDAE EDDDDDEEGN AGEKRDVEMD
DASDEESEGE TKDTKLREED IKNQYQEVTQ FKFNPRDGGS CTIQLQYDID TPKLLLLPLV
EDACRNAVIQ SIPGLGNCTF VEADPIKGEP AHVITDGVNL LAMRDYQDII KPHSLYTNSI
HDMLNLYGVE AARASIVKEM SDVFQGHSIS VDNRHLNLIG DVMTQSGGFR PFNRNGLVKD
GSSPLAKMSF ETTVGYLKEA VVERDFDNLK SPSARIVVGR TGTVGTGAFD VLAPVA
//
