ID G7XLY8_ASPKW Unreviewed; 350 AA.
AC G7XLY8;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00013109};
DE EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109};
DE AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing] {ECO:0000256|ARBA:ARBA00032649};
DE AltName: Full=Uroporphyrinogen-III cosynthase {ECO:0000256|ARBA:ARBA00031702};
GN ORFNames=AKAW_06061 {ECO:0000313|EMBL:GAA87947.1};
OS Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus
OS awamori var. kawachi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1033177 {ECO:0000313|EMBL:GAA87947.1};
RN [1] {ECO:0000313|EMBL:GAA87947.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFO 4308 {ECO:0000313|EMBL:GAA87947.1};
RX PubMed=22045919; DOI=10.1128/EC.05224-11;
RA Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H.,
RA Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.;
RT "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used
RT for brewing the Japanese distilled spirit shochu.";
RL Eukaryot. Cell 10:1586-1587(2011).
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC {ECO:0000256|ARBA:ARBA00004772}.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC {ECO:0000256|ARBA:ARBA00008133}.
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DR EMBL; DF126461; GAA87947.1; -; Genomic_DNA.
DR AlphaFoldDB; G7XLY8; -.
DR STRING; 1033177.G7XLY8; -.
DR VEuPathDB; FungiDB:AKAW_06061; -.
DR eggNOG; KOG4132; Eukaryota.
DR InParanoid; G7XLY8; -.
DR UniPathway; UPA00251; UER00320.
DR Proteomes; UP000006812; Unassembled WGS sequence.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR039793; UROS/Hem4.
DR PANTHER; PTHR12390; UROPORPHYRINOGEN III SYNTHASE; 1.
DR PANTHER; PTHR12390:SF0; UROPORPHYRINOGEN-III SYNTHASE; 1.
DR Pfam; PF02602; HEM4; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
PE 3: Inferred from homology;
FT DOMAIN 36..331
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 350 AA; 39048 MW; BF82E1F9B61BC378 CRC64;
MPSPENTNKP PIILLKTKST PHDNYSDYFH QPTSNYTPTF IPVLSHNFHT ERLRSIRALF
TSGQLLPSQK NNDRKYGGLI FTSQRAVEGF GRVLAELDDD SSALNTLKTS SQNLPIYTVG
PATSRSLTTT IVDKYLPHAS IHGADTGNGE ALAKYILEHY NSLYTTTTTS NPNGEDDVYN
NKPPLLFLVG EQRRDIIPRT LMNPDLPPGE GVGVDEVVVY ETGVMEGFEE SFKGVIERER
EVMKKNNTTE EGKGRVVWTV VFSPTGCEGM LRGLGYIGSE DGSGWGWRKV DGDGERRRFF
VATIGPTTRD YLRREFGFEA DVCAERPSPE GVGEGIERFM REMMKSSEET
//
