ID   G7XRX5_ASPKW            Unreviewed;       880 AA.
AC   G7XRX5;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   SubName: Full=RhoGAP and Fes/CIP4 domain protein {ECO:0000313|EMBL:GAA89655.1};
GN   ORFNames=AKAW_07769 {ECO:0000313|EMBL:GAA89655.1};
OS   Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus
OS   awamori var. kawachi).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1033177 {ECO:0000313|EMBL:GAA89655.1};
RN   [1] {ECO:0000313|EMBL:GAA89655.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFO 4308 {ECO:0000313|EMBL:GAA89655.1};
RX   PubMed=22045919; DOI=10.1128/EC.05224-11;
RA   Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H.,
RA   Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.;
RT   "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used
RT   for brewing the Japanese distilled spirit shochu.";
RL   Eukaryot. Cell 10:1586-1587(2011).
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DR   EMBL; DF126469; GAA89655.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7XRX5; -.
DR   STRING; 1033177.G7XRX5; -.
DR   VEuPathDB; FungiDB:AKAW_07769; -.
DR   eggNOG; ENOG502QQWB; Eukaryota.
DR   InParanoid; G7XRX5; -.
DR   Proteomes; UP000006812; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd04399; RhoGAP_fRGD2; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR   PANTHER; PTHR23065:SF17; RHO-GTPASE-ACTIVATING PROTEIN RGD2; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00055; FCH; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils}.
FT   DOMAIN          2..430
FT                   /note="F-BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51741"
FT   DOMAIN          227..296
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          464..662
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          672..880
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          116..143
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        685..703
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        711..726
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        727..858
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        859..875
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   880 AA;  98120 MW;  6150FA6E4A446426 CRC64;
     MPGFADSFWT PDYATGLGVL YGKLQQGAVE NKQIITIASM RADAEEQYGL KLGEIAPTVD
     RVTPTGFGKD DGASVRKAYE GVRTEMVEAS KNHQKIASNI RELVVSPFRR WCDQHEARIQ
     NSHDDLQARI KEHSKQVDLV KKLRSHYFNK CRVVEDLEEE NKLAFQAPET SPKIKPTPKI
     VLPEEQEEEE PVEIGDRIYP PEDLKRLLTH MLENIKIGEV KVPIIGTYQN TSTGADIVEY
     TQKHLNGTSI TYSERIGQDL VDNGFLRLVG NMGSTFANSS KMRYQWRPKV FQITGVPEKK
     KPLMRVTSVA TSEDGSESPL SSVSEMLAGW NPLNNPYPNE TPAEKLRREA READERYKAA
     VRKLDMIRCK LEEEVVENLR FMEQCELDRL KAIKAVILDF SGAISNVIPN LQSTVDHMML
     YQETIQPLGD LRYLLENYRT GGFVPRVQAY ENYYGSVEDQ NFGVDLEARA RADRKRVPIV
     VTTLLTYLDN RYPDLEGDEA RRAIWLYDVP LAATHHLRSA LNNSKADYNE ILEKYEIPII
     ASVLKLYLLE LPDSLVSSQV YEIVKTIYST TAHETTEEGR IKVLQSTLGQ LRLNNIATLD
     AIMTHFTRLI DLTSADESYV SALAQALSPC ILRPRTESSL TMNERHSYRL IRDLFAHKDA
     IFGELKRQSS ALGISGSTNR PRAISTDESN RRAAMEARNR AILDRSRANS PAPPQKHRRD
     RSSGASETRR FPINVTSPTE RRTVARSSLD VPIKSESPTA AEQMTSVNIN GPEPVTNGAL
     SESPVSAAAS ASPSSGSASP PPAPESDASV TPTTTPTQDT EKRSSTISRS SVSYTRKPGL
     GNRSSFPAVA STEGTDSKRS SLAETEPKGV TLEDKPMDDD
//