ID G7XXD9_ASPKW Unreviewed; 386 AA.
AC G7XXD9;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=hydroxymethylglutaryl-CoA reductase (NADPH) {ECO:0000256|ARBA:ARBA00012999};
DE EC=1.1.1.34 {ECO:0000256|ARBA:ARBA00012999};
GN ORFNames=AKAW_09712 {ECO:0000313|EMBL:GAA91598.1};
OS Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus
OS awamori var. kawachi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1033177 {ECO:0000313|EMBL:GAA91598.1};
RN [1] {ECO:0000313|EMBL:GAA91598.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFO 4308 {ECO:0000313|EMBL:GAA91598.1};
RX PubMed=22045919; DOI=10.1128/EC.05224-11;
RA Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H.,
RA Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.;
RT "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used
RT for brewing the Japanese distilled spirit shochu.";
RL Eukaryot. Cell 10:1586-1587(2011).
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661}.
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DR EMBL; DF126482; GAA91598.1; -; Genomic_DNA.
DR AlphaFoldDB; G7XXD9; -.
DR STRING; 1033177.G7XXD9; -.
DR VEuPathDB; FungiDB:AKAW_09712; -.
DR eggNOG; KOG2480; Eukaryota.
DR InParanoid; G7XXD9; -.
DR Proteomes; UP000006812; Unassembled WGS sequence.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR GO; GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00643; HMG-CoA_reductase_classI; 1.
DR Gene3D; 3.30.70.420; Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR InterPro; IPR023076; HMG_CoA_Rdtase_CS.
DR InterPro; IPR004554; HMG_CoA_Rdtase_eu_arc.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR PRINTS; PR00071; HMGCOARDTASE.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR PROSITE; PS00318; HMG_COA_REDUCTASE_2; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166}.
SQ SEQUENCE 386 AA; 41804 MW; A181977F4805D533 CRC64;
MAPPSEKTKA QISQILTGVE HITRHNQDPF KVKIENFIGY THVPVGLAGP LHIRTPTGPD
KEIWAPMATT EAAVVASCCR GCKVANASGG IEVHMEEEGM TRGPVFRFQN PGDALRFARA
LPTLQASFKE VAESTSKHAR LQSLKPHTIG SSVHLLLSYA CGDASGQNMV TIATDWIRDW
VSKNLEKEYK VVDTFVEGML SSDKKPSWRN VAVVRGVETV AWTALSDSAC QRVLGCSSAQ
LYNFIQTTQE AGIRNGQHGS NMDSANILAA IFIATGQDPA CVADASWAHL TPEYDQASKT
ITLSLYFPSM PVGVIGGGTS YATQQEGLRI MQCNEPGGKR RLAGYIAAFA LALEISSASA
VVTKTFARSH KRLARWEASE RPRSKL
//
