ID G7XXM8_ASPKW Unreviewed; 489 AA.
AC G7XXM8;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Hsp90 chaperone protein kinase-targeting subunit {ECO:0000256|ARBA:ARBA00031396};
GN ORFNames=AKAW_09840 {ECO:0000313|EMBL:GAA91726.1};
OS Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus
OS awamori var. kawachi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1033177 {ECO:0000313|EMBL:GAA91726.1};
RN [1] {ECO:0000313|EMBL:GAA91726.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFO 4308 {ECO:0000313|EMBL:GAA91726.1};
RX PubMed=22045919; DOI=10.1128/EC.05224-11;
RA Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H.,
RA Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.;
RT "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used
RT for brewing the Japanese distilled spirit shochu.";
RL Eukaryot. Cell 10:1586-1587(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the CDC37 family.
CC {ECO:0000256|ARBA:ARBA00006222}.
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DR EMBL; DF126483; GAA91726.1; -; Genomic_DNA.
DR AlphaFoldDB; G7XXM8; -.
DR STRING; 1033177.G7XXM8; -.
DR VEuPathDB; FungiDB:AKAW_09840; -.
DR eggNOG; KOG2260; Eukaryota.
DR InParanoid; G7XXM8; -.
DR Proteomes; UP000006812; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR Gene3D; 1.20.58.610; Cdc37, Hsp90 binding domain; 1.
DR InterPro; IPR004918; Cdc37.
DR InterPro; IPR013873; Cdc37_C.
DR InterPro; IPR013874; Cdc37_Hsp90-bd.
DR InterPro; IPR038189; Cdc37_Hsp90-bd_sf.
DR InterPro; IPR013855; Cdc37_N_dom.
DR PANTHER; PTHR12800; CDC37-RELATED; 1.
DR PANTHER; PTHR12800:SF4; HSP90 CO-CHAPERONE CDC37; 1.
DR Pfam; PF08564; CDC37_C; 1.
DR Pfam; PF08565; CDC37_M; 1.
DR Pfam; PF03234; CDC37_N; 1.
DR SMART; SM01069; CDC37_C; 1.
DR SMART; SM01070; CDC37_M; 1.
DR SMART; SM01071; CDC37_N; 1.
DR SUPFAM; SSF101391; Hsp90 co-chaperone CDC37; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT DOMAIN 2..191
FT /note="Cdc37 N-terminal"
FT /evidence="ECO:0000259|SMART:SM01071"
FT DOMAIN 189..360
FT /note="Cdc37 Hsp90 binding"
FT /evidence="ECO:0000259|SMART:SM01070"
FT DOMAIN 381..480
FT /note="Cdc37 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01069"
FT REGION 95..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 143..174
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 208..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..480
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 489 AA; 54445 MW; ABF1CACFAEA684AC CRC64;
MVLDYSKWDA LELSDDSDIE VHPNVDKRSF IRAKQAQIHQ QRAQRRHEIE TLKYEHIVNN
GLLSRIDKLL TALKQNEGSK SVEEVIFQNL MEFAGNPSDD HPPAAPAGVH TQEKEQPKYS
QMMSALVDQV KKEMGDVSSE NLYQEYIKGV QRHNDKVQGL QKELLQRLAQ LEKEEGSKIT
SEGLHEGFNT SHIAKPGEAK GQKTETVELL NPGASTAGSS QQAAAPAADD DDEEEDPENV
KASELAKRFA KINRNDYRAL LQFISENPQI VAEKETDGLL VEAFNSQMEG KEDYARTCVH
QGLLLQYCRS LGRDGISLFF KRITNADHQA GTLFRNDVNE TYHKIKTRAA ELAKDGSASN
DPAGVEQIQL HAVDPNTKIT INIPSAEGDD PVEVEARKVF ESFSKDLQKA LASESLDEVN
KVLGKMSVEE AEDVVEKLGQ SGMLSLEEGI VDATTEEGRK KLEEIEAENK REREEQEVGE
PGGDITELD
//
