ID G7XZP3_ASPKW Unreviewed; 601 AA.
AC G7XZP3;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Beta-hexosaminidase {ECO:0000256|PIRNR:PIRNR001093};
DE EC=3.2.1.52 {ECO:0000256|PIRNR:PIRNR001093};
GN ORFNames=AKAW_10516 {ECO:0000313|EMBL:GAA92402.1};
OS Aspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus
OS awamori var. kawachi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1033177 {ECO:0000313|EMBL:GAA92402.1};
RN [1] {ECO:0000313|EMBL:GAA92402.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFO 4308 {ECO:0000313|EMBL:GAA92402.1};
RX PubMed=22045919; DOI=10.1128/EC.05224-11;
RA Futagami T., Mori K., Yamashita A., Wada S., Kajiwara Y., Takashita H.,
RA Omori T., Takegawa K., Tashiro K., Kuhara S., Goto M.;
RT "Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used
RT for brewing the Japanese distilled spirit shochu.";
RL Eukaryot. Cell 10:1586-1587(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231,
CC ECO:0000256|PIRNR:PIRNR001093};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285, ECO:0000256|PIRNR:PIRNR001093}.
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DR EMBL; DF126493; GAA92402.1; -; Genomic_DNA.
DR AlphaFoldDB; G7XZP3; -.
DR STRING; 1033177.G7XZP3; -.
DR VEuPathDB; FungiDB:AKAW_10516; -.
DR eggNOG; KOG2499; Eukaryota.
DR InParanoid; G7XZP3; -.
DR Proteomes; UP000006812; Unassembled WGS sequence.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR029019; HEX_eukaryotic_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF14845; Glycohydro_20b2; 1.
DR PIRSF; PIRSF001093; B-hxosamndse_ab_euk; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|PIRNR:PIRNR001093};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR001093};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..601
FT /note="Beta-hexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003506053"
FT DOMAIN 25..161
FT /note="Beta-hexosaminidase eukaryotic type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14845"
FT DOMAIN 184..546
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 348
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
SQ SEQUENCE 601 AA; 67370 MW; E40C56B90B04ED51 CRC64;
MLLHHLWLAC LTLLVAGAAA VKVNPLPAPR NITWASSGPK QLADFVSLRT SRDTSDFILA
NGWNRAWNSI VSLQWVPAAT QGPVPSYQPF PTGTAGATKR SPQALPSLQF VDVNVLDVAA
DLQHGVDESY TLEVTEGSTS VVIEAPTVWG ALHAFTTLQQ LVIADGQGGL IIEQPVKIQD
APLYPYRGIM IDTGRNFISV NKIYEQLDGM SLSKLNVLHW HMEDTQSWPV EIDAHPEMIY
DAYSPREVYS HADMRNVVAY ARARGVRVIP ELDMPSHSAS GWKQVDPQMV TCVDSWWSND
NYALHTAVEP PPGQMDIIYN GTYEVVRQVY NELSSIFPDN WFHVGADEIQ PNCFNFSSYV
TEWFAQDPSR TYNDLAQYWI DHAVPIFQNY STSRQLVMWE DIVLSTEHAH DVPTNIVMQT
WNNGLDYINQ LTAKGYDVIV SSADFMYLDC GIGGFLTNDP RYDVMSNPDA STPNFNYGGN
GGSWCAPYKT WQRIYDYDFT QNLTATQAQH IIGAEAPLWS EQVDDVTVSS LIWPRAAALA
ELVWSGNREN GQKRTTLMTQ RILNFREYLV ANGVQATALV PKYCVQRPHA CDLYLNQSVI
Q
//
