ID G7Y3D9_CLOSI Unreviewed; 3163 AA.
AC G7Y3D9;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Cullin-associated NEDD8-dissociated protein 2 {ECO:0000313|EMBL:GAA47476.1};
GN ORFNames=CLF_100411 {ECO:0000313|EMBL:GAA47476.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA47476.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA47476.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA47476.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the CAND family.
CC {ECO:0000256|ARBA:ARBA00007657}.
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DR EMBL; DF142840; GAA47476.1; -; Genomic_DNA.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0010265; P:SCF complex assembly; IEA:InterPro.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR039852; CAND1/CAND2.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR013932; TATA-bd_TIP120.
DR PANTHER; PTHR12696:SF0; CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR12696; TIP120; 1.
DR Pfam; PF01426; BAH; 1.
DR Pfam; PF08623; TIP120; 1.
DR SMART; SM00439; BAH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51038; BAH; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 110..246
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REPEAT 1950..1988
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REGION 17..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 891..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1052
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1142..1172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1240..1269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1292..1331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1507..1579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1707..1779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2176..2198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..562
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..822
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..915
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..1004
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1046
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1529..1579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1707..1721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1763..1779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2178..2198
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3163 AA; 343658 MW; F348E3E2AD7F5B56 CRC64;
MTDCAFLPST CDANYHDEAT PPNLSNTDPA VQTDYHPVET ESTKGAGEPV ESNGDYNLEV
PLRRSKRGKG KGTNSTASAT AAAGANTGAT NGSGGGVAEE RVSSCLVNGT EYQTGNFVYY
EEPDFEYFTI GLIEEIKFSR RDKFAITVKC FYRTHDIPES SKQCILEREL FHSPSNSLRK
AEVLSRELFV SEVQETIASK QLRGRCKVSH LQDLRTALNT FSPDEEDCFF YVFAYNPETR
RLMHTRAEIR VGHAFQANIP RFRHLPPATY HPHPHRLRCG RRCRFLHNSH GHYPRRSKVP
RVPPGGLLDE SKPELDERTH SPTAAASVTE VPHNMEECIS QKHPQTVEEQ CKLEDADLDT
DVPKSPPALE NFSSVRHGED SPSLERLHPH RHTVAESPVR KLLSRRRRAR RFETLTWRPH
GLAKRLSAAN NLNASEVNHL FNGDIVDEPL KTYLDAVRSM DTPRHWTADQ VRLFAYALRV
HGKDFFAIQR DFFGGRASAV TTTPSTQLGH AGTGNTPSSG RLRGRGRRRA GVSGVGCNHK
VKADEEEMMT DLKTEDHPQA GEESDQGLSN DATGDNKPVK TVKELIAFYY YWKRKGAASA
ASPSMLVTTN HQGGLTGAAV NFAAAVACAN ADGQSVLGNG ANLNGVVSQI SSQQPQQLQQ
QQQPLTGVGG KRRKPTTSRG NAPRASTPAS ELSESACASL PDSETDGPPE AYETSDYSVI
AKDDKDSLFE VASNKLAGSE QDLPPSGRLR RRLCRNCAKE LPSPTDTLQP TGVGQLRFLC
HACRNHLQKY GELKSTSLAS YPPPQLHSEV SHPPSSCVET TDEGKLSIDH TATEDPTHGS
PVSPVASPVS CSRHSWNPDA QTSSLYSSTY SLCHSSPCST ALDSEEYFSS SSSMESDCSS
PSSGSRASSD TGPETFGKDS EGRTLRKRSK RPRYESYPHT STHSKMPCVT HPQVKESSEV
ANAGVSGTAT PPVTKTSPSW PPANSTTGEE SHTSPLQVTI TTSQWSLPDT KKQYSEYTVD
NSASHLPKVE VRARPSPMHH EVEGDDAGDA ESETEVELMA HVSSLTPCLR QIHRSTWSRL
VRIWDRSVTV RVPSDTSRTL FNAGSCSRTD VIYDGRGLTE EELAVARHEL YSRHLETAVG
PGALSIGSGG KTDAAAEPSK HQSRPSESHG SLSCSFAISN SGVHDSTALN LSARTLYSSP
TQRLAPPCSR ASSYDGSALL GQHSSVQSSA ASFKNPSAYL PAARTSTTPN QPSGNNVTPA
PYDPSPTQQQ IQAAYEQAML LAAAATQHHY QQAKLTGQQS REAHQQSHRQ FVASTSAHSP
RPSSTHTSNA KVSAAQLSAR LGAAAGTFYP PALVTSTLNL VSPTGGRPIT AGHVSSQSFP
PTFLSPTLLN SLGAGGHVPT LPHTPGYPSF VNPAVNTPGE ALWKNHDALQ LQLTMMGLLP
PTTPPDPALL YGSMDPRETE AFRLLMAEKF THLRYPPANL SANDQQDFLT TATEMLLRAR
ANLGTGGGTF GDNSNGHTNP VLYPPPPISN TGAMTSAVNS ISTRPTASVQ SPHYRHSSGS
HPSSYSRHPS GLASSQDSHV QLSLPNFNLA PPTAHLGLNT TASRHSSLAS ALTTSYLSPA
LAASTSSAHS RLPTSTTIAN SSVSSASFSR QSSSISAAQQ LQEQMFNAAK LAMLAANMQS
DPSKAFTFAA ALAELAAHEK AQNQSTVTLS HLGNQPSKPT GMSLPPFDMR IPATGGGNSN
STGAHPDRLG SASPFRRRSS GPFGGITSGS PSPSLLPSQT ACGLPPISRP LVGALTNQSR
MMSSPAVTTP SNRFSTATPL PIPNMTPNFA NVFNPGHIPS PSQLAQLSQL THSAGLAPGL
GLQMVSTDTD YRFMGINDLI NELQADSLRL GPLTNKVKEQ LVSAIVKDLI VTMDKGSDEQ
LRGVCSIGLK TVINSLPATN DARAIMNECL VPLMHMAVSH TDDNVRIEAC EVLGELINHL
GNRLTAHHRD LLDCMLCNLS SQQNTLRKRA TQALGGLAWI VSPDLLASLF VYLLSRLRNA
SLFVSSSGKG LSDEQVTAMV TDHPLLQRPL LIDQLKQSAS SELVKTMLQC LNLISRQLLR
TPQQIQPVTQ LLAWILQQPG SAGAVDMDDV HELAIQSLET VVRCCPRVIL PNLPELVALL
CDRLQYDPNY DYNVGEDDMT VDNSDSEGED EEADYSDDED YSWKVRRAAA RALEAVVLTY
PEKTADFYQS IAPLLIKRFN DHEEPVRSNI FSCFATLLRQ TRITPSASSV PFHSQPKVIE
SYNYQHMNYS QLHTRTTSPD CSISHACLHE LAAQLKDPES AQSRLLALLP TICQAIQRQA
SVTSRRAAAS RGTPGIQHVA FMLNRDLALA LPGHLGEHLN SIFTLIHTYS QDPTTNNTVK
IDMVNLVVLL LGTHNPVCFK SNLNLLVQLA LWAMHDPFYR VALEGLELTQ LLSCYLRQLG
QEGQTQTLLV PLYTLLEAND RDLELKEKAV TSAAVFINQL GDLIGADRLE QCLEVLYRRL
TNELTRLTTV RAIHIISVSP FTLNLRQFLP KASDELATFL SKNDRLLRLA TLRCLYTIWS
KHPGLVGPHC LDTVFEVLPK LLTSEQDQLA IHLVSLLLES FSADHNGLDD RITQFITTNA
FVQPVIGLAH SPLLRGQALG AMLRLMRAIG RRAIRNGQEQ GGIMTLFLSR LLAPLNGSGL
LVVSGSTSSV LLHRDALPSL AQCVAELLAE LPTVSSSGKA ASSVASVGVA VDRLIAAVRN
ADSSVTQIYL NLLILGELGR KVCLLMASSG LPEEGTRLVV AECLGRLILV SPRDLINRLR
RQLTSPEASC PLVRCTLVTA IRSILIATDL DTNSHHPMLS GQSRLDSFDW ATIGLLPSGL
LLSTVASSPL QQHESDDPEK TTRTAVLLEV DSILRSEQPP PLLDFLSRLA DPDILVRRAS
LMALNTAAHH RPGLVRPLLN MPLDLSGHVT TLLKLLYGET VVRPELIREV EMGPFKRKED
DGLDLRKCAF ECMFTLLENC LDKLVMSDFL DPLIKGLKDH TDIQLLSYQI LQHVACVRPL
EIAAKMEALS VPLKAVLLSK PKEDWVKQEL EKQQELSRAA VAAIVQFKSI ENIDKNRSYL
DLLRTIETEP ALKSMYTTMA AQDTPASFSR KIPGTAPSYA YNP
//
