ID G7Y408_CLOSI Unreviewed; 1141 AA.
AC G7Y408;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Putative transporter SVOPL {ECO:0000313|EMBL:GAA47694.1};
GN ORFNames=CLF_100686 {ECO:0000313|EMBL:GAA47694.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA47694.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA47694.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA47694.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000256|ARBA:ARBA00008335}.
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DR EMBL; DF142849; GAA47694.1; -; Genomic_DNA.
DR AlphaFoldDB; G7Y408; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0005892; C:acetylcholine-gated channel complex; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR033438; MOLO1.
DR PANTHER; PTHR23511; SYNAPTIC VESICLE GLYCOPROTEIN 2; 1.
DR PANTHER; PTHR23511:SF5; TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03500)-RELATED; 1.
DR Pfam; PF17175; MOLO1; 1.
DR Pfam; PF00083; Sugar_tr; 2.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 688..709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 716..735
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 741..763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 775..797
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 803..821
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 881..902
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 952..973
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 980..998
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1004..1026
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1038..1058
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1070..1090
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 649..1093
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 1141 AA; 126691 MW; 8CF3A0D774A102C3 CRC64;
MLKEFRNLRS RDESMCSPHS PHPVIALALV NKLKVGNENP DRLLSYASIF TYYLFNEWNL
PSTCHTGSDK VIIFYSKDDG VIYTFAGNLL ERKLPSQRII DFAVESRIHF SNGIAAGLGF
LIQRYRFRLR TPGDAAGYAG VNVVLSDRAE ASLHDWIFLD SGLCAVRLAT SVRESRENEV
HRNLFITSAY APNDCSSGSA KDNFGDGLRV LLQRANIRNV VVVGSGCSGC SPFFAQRYAD
FLIDVPKVAV SKFAVIFGPK HLVYNILMFS HLFKFVKFYG CLDRFSCFPY ESELGHLKHY
IHVPKPPAFQ LHRRLAELVE LDAFEGGIFL GDVGLPLRPS ATCGCHRCPN PTVSTIGNIS
VSDAPPVPDE ALITCVTEFE EDLLYAPETA YEAGCFSTHE QALTEPLLPL SSMDELRRCE
EHPREQLWSA LCTAGVRKTR TPRLAIEKLV DPEVKRNYQN QLVECLPDGT VSDINGHWEK
ISKALLKVGT SVCGTTQPTS FKHWISDRTV SLLETRRQIP PGHHHNSTRR IIRRQVKLSV
RADREAWWTR KAQEMEDAKN AGNVRRLFHL IRSTGPRKPL VSETIRDQNG SLICNKAERL
PRWAHFIHLD DAKKRQSALN GKSFDDTDSE GKTYTVEDAV EAAGFGRFQL LLCVICGVLM
AADAMEMLLL SILGPALRCS WLLSSEEIAA ITTVVFAGFL IGSPIWGFVS DRFGRWPTFF
TVLTLISYYG FLTAVSPTYV WVLILRFTVG FAIGGCSSSF ALLSEFLPVK YRAKVLLGFQ
IFWAIGSTFE VGIAYLILPR FGWRWLVFAS ALPLALFLGL MKLLPESPRY LVTAGYTVEA
EKVIARLFRT NRATPIEGKL TSTPVSAKSL GSVKQLFGKR YLITTLMLPM IWFGAAFGYY
GVVLLSAEIF RFRHSCFGAP STPPEVLNAT LPNDDTPPVD TSCCRDMNDD DFVAMLVSSV
GEFINVPLMV LVIDCFGRKI TMGVWNGLTG LMFFLLYVCM SKEAMTGVLF VVRAFSAGLL
SLAYLYTTEV YPTSCRAIAV GSFSSISRVG AIVTPYVAQV MMPEVSQIGA LSLYAAVGVL
SSILAFSLPI ETAGRELPGL LSFVKRRMLL PSLRAKNCSI YIPFDASAQV QSGYHITPGC
T
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