ID G7Y4V3_CLOSI Unreviewed; 1180 AA.
AC G7Y4V3;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 28-JUN-2023, entry version 52.
DE SubName: Full=Suppressor of cytokine signaling 7 {ECO:0000313|EMBL:GAA47989.1};
GN ORFNames=CLF_101052 {ECO:0000313|EMBL:GAA47989.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA47989.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA47989.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA47989.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DF142864; GAA47989.1; -; Genomic_DNA.
DR AlphaFoldDB; G7Y4V3; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF5; SUPPRESSOR OF CYTOKINE SIGNALING 7; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 967..1075
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 1071..1120
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 123..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 747..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 871..943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1142..1180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..602
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..778
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1180 AA; 128775 MW; 19E58341E0CBB556 CRC64;
MPRENPACKC NRPHKLPHLL TETSPTEISV FCTTTATASV TSGTTTDDTG IESAASLGAS
PTLPCSSKLI QHADIKRPPW NPEQPPPIPP KANRRVLNRR ISPDRSSICS RFCEGPRFLS
SPRQFSPTAA ATNSPPATQL HPSRRDDCPT IVNVQPKSVS AQNYSIPPNT ASRSLRFNRR
CLHPTSESSQ PSGIAPFRSS DECVHNTNHP NSRRVDSSGY SVAVGDLRHF TPSSHPTSYA
HLPVTDGLVE SGTIRPPCVC QLNRHVHTKA LPPIPTHDRH RTIRSLNTSS SDPRRDQWVD
PCSGYGPTTN RYDDGTQNLA SKLGCGGLLW ISSSFVRLFR YSTSRGKLLE IKRKRLFSRS
SAQRNTTTEA TTPSSGDRWQ SAPLAREGER EVVSANTLSE HLNKLISTNT VTCGAAIWDR
QSRTPCPVEL LDNVNTSSHS SPLSTNATAV HSPPSNKHVL PSPTPISIDP DIFSALAQCP
CCSSKYDQSK LTSVHSVSQS GRTHPLPPSR TTETPSRHSL SLIRPHCCAC PSDPHKPCSC
VQSLQFIPNN MSQAHTSDSH PTSASQFHSR RCVTPSNQRL SGIDPSLSDR PHRKENRIRR
PLTDHRHSKA THKKTSERLS SSSLTSSDAD HPDELPGVGL PSSSSKVTAT SDHLHCIGSS
LPTGLANSEL TSGTETVQPC PSCIFADLSL PRRSPGRSSL RTAGPVDGTV MIPTAFDFEP
SQQQKTVCFV DPQHQIHHHV HHIHHVHHVH HHHHHHQQQQ LDRPSESATL QHAGSTTSPR
TLCCDRCFLD GTPVSCCSLE AGVWRTSTAS SCLTTRLTTH QASSQLCSLR ESPSCLTSNQ
FPLDSTDSCR AICSSSAALC SDVAVSTAGR SADQVGRTAN LTDSTRSRST PSTVRTNGTC
ATQAYPPVSH STAASALTSP SSSVCRSPRT ASSPPSTPVT ASSAAVDVQA GRLSFQRSML
ELRKVGWYWG PLSFREAQVL LAKRPDGTFL VRDSGHDTYI LSLSFRVRGE TYHTRIGHSQ
GRFSFWSQPQ SHSASTMVEF IEKAVDHSIS GQFHYFLQNI AQGQPPVEVP LLYPLSRFQV
VPSLRHLARF TILSFVRRDH IDKLPLPSRV LTYLKEKQYY VESLEAFEEA IRDRSPLEFR
PRSADVASNV GRSNSDRLAN NLSETATADA AGPHPPPATS
//