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Database: UniProt
Entry: G7Y4V3_CLOSI
LinkDB: G7Y4V3_CLOSI
Original site: G7Y4V3_CLOSI 
ID   G7Y4V3_CLOSI            Unreviewed;      1180 AA.
AC   G7Y4V3;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   28-JUN-2023, entry version 52.
DE   SubName: Full=Suppressor of cytokine signaling 7 {ECO:0000313|EMBL:GAA47989.1};
GN   ORFNames=CLF_101052 {ECO:0000313|EMBL:GAA47989.1};
OS   Clonorchis sinensis (Chinese liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX   NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA47989.1, ECO:0000313|Proteomes:UP000008909};
RN   [1] {ECO:0000313|EMBL:GAA47989.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Henan {ECO:0000313|EMBL:GAA47989.1};
RX   PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA   Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA   Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA   Yu X.;
RT   "The draft genome of the carcinogenic human liver fluke Clonorchis
RT   sinensis.";
RL   Genome Biol. 12:R107-R107(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Henan;
RA   Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA   Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA   Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA   Wu Z., Yu X.;
RT   "The genome and transcriptome sequence of Clonorchis sinensis provide
RT   insights into the carcinogenic liver fluke.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DF142864; GAA47989.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7Y4V3; -.
DR   Proteomes; UP000008909; Unassembled WGS sequence.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF5; SUPPRESSOR OF CYTOKINE SIGNALING 7; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          967..1075
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          1071..1120
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          123..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          271..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          360..388
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          437..459
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          493..518
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          551..647
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          747..778
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          871..943
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1142..1180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..140
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        271..285
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        360..379
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        437..457
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        551..584
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        586..602
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        762..778
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1147..1167
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1180 AA;  128775 MW;  19E58341E0CBB556 CRC64;
     MPRENPACKC NRPHKLPHLL TETSPTEISV FCTTTATASV TSGTTTDDTG IESAASLGAS
     PTLPCSSKLI QHADIKRPPW NPEQPPPIPP KANRRVLNRR ISPDRSSICS RFCEGPRFLS
     SPRQFSPTAA ATNSPPATQL HPSRRDDCPT IVNVQPKSVS AQNYSIPPNT ASRSLRFNRR
     CLHPTSESSQ PSGIAPFRSS DECVHNTNHP NSRRVDSSGY SVAVGDLRHF TPSSHPTSYA
     HLPVTDGLVE SGTIRPPCVC QLNRHVHTKA LPPIPTHDRH RTIRSLNTSS SDPRRDQWVD
     PCSGYGPTTN RYDDGTQNLA SKLGCGGLLW ISSSFVRLFR YSTSRGKLLE IKRKRLFSRS
     SAQRNTTTEA TTPSSGDRWQ SAPLAREGER EVVSANTLSE HLNKLISTNT VTCGAAIWDR
     QSRTPCPVEL LDNVNTSSHS SPLSTNATAV HSPPSNKHVL PSPTPISIDP DIFSALAQCP
     CCSSKYDQSK LTSVHSVSQS GRTHPLPPSR TTETPSRHSL SLIRPHCCAC PSDPHKPCSC
     VQSLQFIPNN MSQAHTSDSH PTSASQFHSR RCVTPSNQRL SGIDPSLSDR PHRKENRIRR
     PLTDHRHSKA THKKTSERLS SSSLTSSDAD HPDELPGVGL PSSSSKVTAT SDHLHCIGSS
     LPTGLANSEL TSGTETVQPC PSCIFADLSL PRRSPGRSSL RTAGPVDGTV MIPTAFDFEP
     SQQQKTVCFV DPQHQIHHHV HHIHHVHHVH HHHHHHQQQQ LDRPSESATL QHAGSTTSPR
     TLCCDRCFLD GTPVSCCSLE AGVWRTSTAS SCLTTRLTTH QASSQLCSLR ESPSCLTSNQ
     FPLDSTDSCR AICSSSAALC SDVAVSTAGR SADQVGRTAN LTDSTRSRST PSTVRTNGTC
     ATQAYPPVSH STAASALTSP SSSVCRSPRT ASSPPSTPVT ASSAAVDVQA GRLSFQRSML
     ELRKVGWYWG PLSFREAQVL LAKRPDGTFL VRDSGHDTYI LSLSFRVRGE TYHTRIGHSQ
     GRFSFWSQPQ SHSASTMVEF IEKAVDHSIS GQFHYFLQNI AQGQPPVEVP LLYPLSRFQV
     VPSLRHLARF TILSFVRRDH IDKLPLPSRV LTYLKEKQYY VESLEAFEEA IRDRSPLEFR
     PRSADVASNV GRSNSDRLAN NLSETATADA AGPHPPPATS
//
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