ID   G7Y606_CLOSI            Unreviewed;       648 AA.
AC   G7Y606;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   ORFNames=CLF_101550 {ECO:0000313|EMBL:GAA48392.1};
OS   Clonorchis sinensis (Chinese liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX   NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA48392.1, ECO:0000313|Proteomes:UP000008909};
RN   [1] {ECO:0000313|EMBL:GAA48392.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Henan {ECO:0000313|EMBL:GAA48392.1};
RX   PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA   Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA   Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA   Yu X.;
RT   "The draft genome of the carcinogenic human liver fluke Clonorchis
RT   sinensis.";
RL   Genome Biol. 12:R107-R107(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Henan;
RA   Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA   Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA   Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA   Wu Z., Yu X.;
RT   "The genome and transcriptome sequence of Clonorchis sinensis provide
RT   insights into the carcinogenic liver fluke.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR   EMBL; DF142886; GAA48392.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7Y606; -.
DR   Proteomes; UP000008909; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd18787; SF2_C_DEAD; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR47958; ATP-DEPENDENT RNA HELICASE DBP3; 1.
DR   PANTHER; PTHR47958:SF31; RNA HELICASE; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000313|EMBL:GAA48392.1};
KW   Hydrolase {ECO:0000313|EMBL:GAA48392.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008909}.
FT   DOMAIN          31..205
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          233..382
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   648 AA;  73063 MW;  565F197101E24DB0 CRC64;
     MYCCRPLPLL KGIYSMGFYK PSMIQERALP CLISSEYPNM IAQSQSGTGK TATLLMAMLA
     RVDATHNFCQ CLCLVPTREL AVQLVEVGRQ MAVHMEGVKF CVATREPQAS TDDDGYVTDQ
     VVIGTPGTIA GWLRQMGPVR LDASCLKMFV LDEADVLLEV EGFCNIAMRA KQRLPRSCQI
     LLFSATFEDD VIEFAHEFVP NPIEFRMKRN QLPLRNIRQY HLEFQDWVDK YNALTEIYGG
     FDVGQAIIFC ATRKEAAWLE GRMTMDGHRV GMMSGDLDVS RREATIHEFR QGNCRVLITT
     NLCARGLDIP QVNLIINWNM PTDASGGADC ETYLHRIGRS GRFGKGGVAV NFITSEEKYL
     LQELESHFAA IPVTNRTVTN LSFAEKLFSC SILSVPNCHA TRRKHEGWVT ARLSKPLTRS
     VSYPIVSRPE SLRYSLLDRH KGGFNAFTET CSNQLNFALF DPLDGCTKQA DHKRLVRSEK
     WCYVEATDSD VIPANKDAHL RIFYVGLISR MGKQCVSPQV ARAQVAVVVL LTLRPFLMTL
     SSIKEGRKKS SLKFSFQECD YTLATTVKET EATTVNQWYS RIVAENWEVP DIAIYRIDLV
     KLSGESDNPE EQQPFSHVEN NGGSSTTFEI IREHAKDELL TKLREYIA
//