ID G7Y6M7_CLOSI Unreviewed; 908 AA.
AC G7Y6M7;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=MAGUK p55 subfamily member 6 {ECO:0000313|EMBL:GAA48612.1};
GN ORFNames=CLF_101819 {ECO:0000313|EMBL:GAA48612.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA48612.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA48612.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA48612.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DF142899; GAA48612.1; -; Genomic_DNA.
DR AlphaFoldDB; G7Y6M7; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd11862; SH3_MPP; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR PANTHER; PTHR23122:SF42; MENAGE A TROIS, ISOFORM A; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 324..379
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 472..559
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 565..634
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 694..908
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
SQ SEQUENCE 908 AA; 101374 MW; 7492FA60EFCC8C84 CRC64;
MSWYLGENCL IWHQWVGLAE VERSGCTTGG IGHGPEKSTR ATSGVPWEVV AHITIPDCAC
TAHLRVMYNR DKGRIVDRCA AQLAAARMSA FVAFEKALQG YMKNNYVAFV LAVGNRKSNA
PLRYECVYYK CRRHPVKLRK FEGSDNAEGA SAFANDKRYT KHGPSGGGYI SPIYFASWKQ
IVLFRRSPDA ENVDKTQGQT FFGKASYSNQ HLAGSYKFRI FLITDDVGAF KKVRKNAKKT
FADPETSELH SIISTKGFKE IVQLNIQIQI AEHIKIGGLC MLHATLTSGT LMVSVKRNVL
TPLEEIFDLL SVSQPEVPGE CENLVALLQD TLEVLYNGPL SVDHNDIESN ELVRLLSTSH
FRSFAEAYTE VATKHFHMPE LPESAFYAIS GTYGTLASLA ASRGSIVPQN IVGDGELALH
GQSASVINAY NEPKLTGTGS MPAYLDGRIN EATLTGGGVG PALPPVEGTM KIVSFEKNLG
EDLGITVVQQ QYMSAHYGLV KELVIKRILT ASRIEQQGLL HEGDVIREAN GVPVDTPQML
QRVLRNAVGT VTFKIIPGYQ STPTTTQLFL RTYFSYNPKN DNLIPCKEAG LPFSAGDVLQ
VLKQEDPYWW QARHYGHHQR AGLIPSIVLQ ERRRAFVQSA PSPEEVTYKM VACGLARRRR
KQVVVPFRAR DADEYETKDI TLYEEVALIS GFQRPVICLI GADGVGRRSL LEMLIRSNRE
RYGTAVLHTT KERDPDEDDE TEFVVDSHAN MEKAHYENKF LEFGEFEGHY YGTKLDSIRE
VINSGRTCLL ACSIQAVPRI RNSEFMPYVV LLAAPSVSCM KAMYEYGMSM GFTHKWKRET
RQGASTMILR GKCKNWSIEG DSEKDCTAES NKIMRMCVPH NMKGKTAQSI EESIQSNGKE
FNRMHVRK
//
