ID   G7Y6N1_CLOSI            Unreviewed;      1238 AA.
AC   G7Y6N1;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=WD repeat-containing protein 59 {ECO:0000313|EMBL:GAA48616.1};
GN   ORFNames=CLF_101825 {ECO:0000313|EMBL:GAA48616.1};
OS   Clonorchis sinensis (Chinese liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX   NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA48616.1, ECO:0000313|Proteomes:UP000008909};
RN   [1] {ECO:0000313|EMBL:GAA48616.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Henan {ECO:0000313|EMBL:GAA48616.1};
RX   PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA   Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA   Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA   Yu X.;
RT   "The draft genome of the carcinogenic human liver fluke Clonorchis
RT   sinensis.";
RL   Genome Biol. 12:R107-R107(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Henan;
RA   Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA   Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA   Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA   Wu Z., Yu X.;
RT   "The genome and transcriptome sequence of Clonorchis sinensis provide
RT   insights into the carcinogenic liver fluke.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DF142899; GAA48616.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7Y6N1; -.
DR   Proteomes; UP000008909; Unassembled WGS sequence.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR049567; WDR59-like.
DR   InterPro; IPR049566; WDR59_RTC1-like_RING_Znf.
DR   PANTHER; PTHR46170; GATOR COMPLEX PROTEIN WDR59; 1.
DR   PANTHER; PTHR46170:SF1; GATOR COMPLEX PROTEIN WDR59; 1.
DR   Pfam; PF17120; zf-RING_16; 1.
DR   SUPFAM; SSF54495; UBC-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT   DOMAIN          1170..1225
FT                   /note="WDR59/RTC1-like RING zinc finger"
FT                   /evidence="ECO:0000259|Pfam:PF17120"
FT   REGION          491..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          957..995
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        961..977
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        978..994
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1238 AA;  137646 MW;  7755B806905FB33F CRC64;
     MPLFQGQNAQ WIAFQKKLLL LSLFVDDHVP LYGDTFDFAT GYRICENAVD TIKTAMELCV
     LCLDQPSTAH RYPLNLKSDP TGLSWHPTEP SLLIVVKNIP EPYLTDQTAD SNGRGSLPPS
     ISDFNWSPLS AYELCSISQR GVLCVWDIRQ PNSPRDKLRS VYSHNTKVYY SPSGSHILTL
     SEPTLWKDVG FNVWNAHNLQ QPAPPLWKAD PLSGAVSRPV QTEPAVKTMT WRIPTSLNSA
     YSRKLDEEDG NGLFRGDDLD GSYDPRAQIG LSPELVTWSE DQTIRRYPIQ IYSAPVDSSF
     ATGVYSKQST ASHVATHAPP LERSATDQRC SLAKRPLGSG RNKHTDVQTK LDETNSRFFT
     AKLHTSTPEP DGSQEENAYR ILAQELSLLT PRVGQYKVEE IDMINRNAKL KLFFCRKLHY
     HHYTVCSVGA DMRGRRPSAD LEEIRDLDSL LIPPGDILPS MDNPARLEQQ WKSPEQCKSA
     TDLHDITRLD GQRQQPQQHA AHTPQLPQSQ QQSITASLAP LNARDSKQLS NSGSSDSSIP
     VAGAVTISVS FPLDYPRSAP QFTILHHYPA LPTELVSRLH EVLRTTASEL VHTCRGCMEP
     CMRKAVDLLQ NIPSNRLLTS VSRQLCPMVT SLITQPPYSN DVQRMSCGSP PVQSLKSLIS
     DPEDRHLSQT PFPRTSGVHF STRGLLVAFG LPLSLSSLRA QLRTTASVFT TDTSDWTPRS
     FKDYRSMMIT CVDTPKVSIG ATSTISGITV AKPLEELSGR TDYMITENDI FTDVEWAQSS
     FSLPPTESQT VVGQRASSRI RPPMGSFPVG TTQPWNNRNS SISSANKLTI KNVIFLDQSV
     TQLYDFSGWV VHKKLIRNYS LSTENVQNMC AHNYLVALNT GRKDIQHFWQ YAVVLTASMT
     KSSFGTLPPL SVQPVGKLLF NEWLSHFLRL CDVQHLAMAI LVLLGLENLY ADTSSDQLAR
     SSGDSKHHER ANQRPFSSKK DQDGSYSCSD SSDPVFSPVA PEVSFNLDNS EDCTPVPEAP
     INRVASGTSL LHTQHNLLVD AYEQHWGFVA SEELPCFAHY ISVYADILYS MGSFLRHARL
     LRAWTDGLKT RWSGLISSSG HKECLSSGKQ SRWPPNPMQS MLLPSCPVCG SSTSYSEVDG
     MEPPIRCHIC SWSLNGSSSS SIVLDKSTIL RCSVCRIQAK GLVFICPKCH HGGHMDHLFQ
     WFSTRSNDGC SRQCPSINCA CSCAFYFFQG NIETHFAT
//