ID G7Y790_CLOSI Unreviewed; 1046 AA.
AC G7Y790;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 08-NOV-2023, entry version 54.
DE SubName: Full=Active breakpoint cluster region-related protein {ECO:0000313|EMBL:GAA48825.1};
GN ORFNames=CLF_102081 {ECO:0000313|EMBL:GAA48825.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA48825.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA48825.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA48825.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DF142912; GAA48825.1; -; Genomic_DNA.
DR AlphaFoldDB; G7Y790; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00159; RhoGAP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037769; Abr/Bcr.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23182; BREAKPOINT CLUSTER REGION PROTEIN BCR; 1.
DR PANTHER; PTHR23182:SF1; RHO GTPASE ACTIVATING PROTEIN AT 1A, ISOFORM E; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909}.
FT DOMAIN 653..777
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 827..1023
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 70..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 148..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 495..522
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1046 AA; 118961 MW; 94C0EB911008EE71 CRC64;
MPLQRHAKCI RIEYEKKGSL ISPIKVEGQP FVAISGTGMK KNNSTGMLEC GNAGAPNDSA
NPESPVILYN PADDDDRSDD DSNLLSLQSP SDAMFRMTVH TPSLETNSEK FPFEKQVDSP
GGRTDLGVRR RARDTGCYRT KIYRELSLRD DPSDSEGEAG EPNETSPAEV KQTWEEKTAA
FEGLTRRKTS LPVMDDRGTM LHYRLNREES KLSLLACLLS KFCDLKSSMN TDLINKAYNI
IQKLHDLQKE FVTKFKQLEP AFDNPDTEVA EVFRCVIQRQ EYLVIYHNLL TGFLDQVPAW
PDITETTEEQ KNHAVNSLRQ TLQEPLNWLV QEAEDVKELW QITPTNNPDQ RAFASLYERL
ITDSIESPLS GQPTKSKDSR KLRMHSLVVE LVNWQSDERK LRYLLLFSDI LVCAKITKDK
SSKHKTGLTD MFRGMRASER NRHFRSVTNV RPLPASINVW NMDEPNARLE TKWMIPLDQL
KLSHNTRVVN DPNKIAIHER AIENLKSNIS KMRNSMKRLD ESKKRDQHKL VRSLRQTEGE
LVLQSPQLVL PLVDSNGQTH YILLVTERER NHWRMALQQE VNQVKSREEC IKSLTQATDG
WNRRGQLWPY AQSSAVTTAA TTTQVPVNEL NTSCRTTAAE MNEVLKKYHY IVRLNKTGMA
ILEEAPGRTG ILRTTVHGIK GLDELDSYHV CIEVDSFAQF EEVARTHVVA HQSNPQWNET
FDLQIDNAHR ICFTIYRHAD VFSEAEVKLT NDLLCDKCIG MPIKTHEPSP RTITFTFTLS
LSRASHMIPQ GSTVQRGKIF GHALRDLVRP PPGQVDGSSR QSVVRDYDLS GEKSQAGYKP
RVPKLVLACT DEVSRRGLRE VGIYRICGSN NEIQALKDIF DQDQEEAMKR LATTDIFVVA
SLLKQFFREI PDGLITTQGS MKLMQLVELP EGSARTQEMQ NWLDGLPRAN RDTLIHMLSH
LLTVSRYSEN NKMDAGNLAL LWSAALFPPL PQLSETRTEK SPNEEIDIHM EAALVFQKTK
SITALMRAVA EGDIQHCEHH SETESR
//
