ID G7Y7B8_CLOSI Unreviewed; 903 AA.
AC G7Y7B8;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=ATP-dependent Clp protease ATP-binding subunit ClpX {ECO:0000313|EMBL:GAA48853.1};
DE Flags: Fragment;
GN ORFNames=CLF_102117 {ECO:0000313|EMBL:GAA48853.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA48853.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA48853.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA48853.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DF142914; GAA48853.1; -; Genomic_DNA.
DR AlphaFoldDB; G7Y7B8; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd19497; RecA-like_ClpX; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR005031; COQ10_START.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR023393; START-like_dom_sf.
DR PANTHER; PTHR48102:SF7; ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR48102; ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR Pfam; PF03364; Polyketide_cyc; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:GAA48853.1};
KW Hydrolase {ECO:0000313|EMBL:GAA48853.1};
KW Nucleotide-binding {ECO:0000313|EMBL:GAA48853.1};
KW Protease {ECO:0000313|EMBL:GAA48853.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909}.
FT DOMAIN 373..525
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 606..697
FT /note="Clp ATPase C-terminal"
FT /evidence="ECO:0000259|SMART:SM01086"
FT REGION 225..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..367
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 903
FT /evidence="ECO:0000313|EMBL:GAA48853.1"
SQ SEQUENCE 903 AA; 98993 MW; 176E4B24877F3F7B CRC64;
MDRRPQGGRR HTQVQWMVSP MMSENNPVVE VGMAAAVLLS NAVNAEVLCE QSSLPVRIVV
RSSAYPKAVY ASMISTTFSG VRAMCTVEVD RRATQLEVES VFKIMGLIKR QLTTSKHKDP
KKSGSEQQYL TSGSDWQTHY PFSDVSRFMK CDACHQLYTL IDKSALKVFG APEETQSFPP
PPPIPKQIHA YLDRFVVGQD RAKRVLAVQV YAHYNRINHN NLVSASEGSS VGQQSANTTS
TGSATSSHSK HPSNSPYIPG VTSPPTSSGG SHSPGSGQSS SVDNFRLPGT SQNSTHLPPG
ALSGPGTSSV AELFNILRSG TLGSSKSGSG SSPGSLSFPF ISDAPHEGQS EADKRRRGSG
LLSDDSDQPV KLEKSNIVLL GPTGSGKTLL AQTLAHCLDV PFAICDCTTL TQAGYVGEDI
ESVISKLLQD ANFNVERAQQ GIVFLDEVDK ISSKAGFLHS IRDVGGEGVQ QGMLKLLEGS
IVNVPDGKGS RKLRGETVQV DTTNILFIAS GAFNGLDKIV GRRKHKKTVG FADLSSLPDP
HQPRAEVNPE REGLDSLFNS FESSATEENA ERDRLLEEVE ARDLIDFGII PEFVGRFPII
TVLHSLNEEM LVRILTEPRN ALLKQYQLLF SIDKCELKVT PSALRAIARE ALSQRTGARG
LRSILERLLL PARYEVPGSD IASVVITEDV VYGPEPIGLS GTSISKTSVF SNSCFFLFSY
GTWALCFATQ LIRLSTCSTI VRPFHEPTVT APPGNRDWFH LPTRERITMG AYEFLFYNEF
AYNASLMDIN LEETPLIARR PLTIYTVKSR FRETTCIDGG EKQGFSRNYL LPNLVWSTDT
YECNSVAHSS HMFEYLINQW NFWPGLVANE NTCMVEFSVD FEFKSALYAK VAGLFFDQVV
AMM
//
