ID G7YBB9_CLOSI Unreviewed; 441 AA.
AC G7YBB9;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Voltage-gated hydrogen channel 1 {ECO:0000256|ARBA:ARBA00015897};
DE AltName: Full=Hydrogen voltage-gated channel 1 {ECO:0000256|ARBA:ARBA00031989};
GN ORFNames=CLF_104291 {ECO:0000313|EMBL:GAA50253.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA50253.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA50253.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA50253.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the hydrogen channel family.
CC {ECO:0000256|ARBA:ARBA00008437}.
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DR EMBL; DF143027; GAA50253.1; -; Genomic_DNA.
DR AlphaFoldDB; G7YBB9; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030171; F:voltage-gated proton channel activity; IEA:InterPro.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR031846; Hvcn1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46480; F20B24.22; 1.
DR PANTHER; PTHR46480:SF1; VOLTAGE-GATED HYDROGEN CHANNEL 1; 1.
DR Pfam; PF00520; Ion_trans; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 75..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 195..280
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 419..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 441 AA; 50450 MW; 74C4F8673015598A CRC64;
MLKWCFYSRV CLKVEIWYGY DFDWSRNRAI LKQLVKDNID ISMLKDEMST TLQQRGRKTW
RQYLLTILRS HMMQIILSLL VLLDAGIVIT EIVLEIQSLQ KANAQLNHTP SKSGAALRRT
RKYSKIILHR QRNGTHLQTF SEIHRQPRNY TTPTTPNIAL SDVQIDRLGE ENIFAHDPLS
FTHGTNVDNS AQMMHEASEV LHYLSIAITG LFLICVIIKI ICLKRKFLRD TNEYFDAGII
MASFASDVLY VRYASETAAA MVVFLLWRII RIINALMMHK QQQYELRIAM QKRARRLLGR
KMEIIRTEKE MQDKHIGALE DLLRELGASA EVIRRCKPRY KKCTKEQTNN ALKSIAALTT
GVMGGLVGAP SNFQGVISKY GGTGINTPTA SQKSLQDTDL AVGMFRFVGA HEQQFWQHPD
KDLPTELPPS VQKPEKGQPF A
//
