ID G7YJM8_CLOSI Unreviewed; 959 AA.
AC G7YJM8;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 28-JUN-2023, entry version 40.
DE SubName: Full=Tight junction protein ZO-3 {ECO:0000313|EMBL:GAA53161.1};
GN ORFNames=CLF_109677 {ECO:0000313|EMBL:GAA53161.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA53161.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA53161.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA53161.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DF143433; GAA53161.1; -; Genomic_DNA.
DR AlphaFoldDB; G7YJM8; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR13865:SF28; POLYCHAETOID, ISOFORM O; 1.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS51145; ZU5; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008909}.
FT DOMAIN 165..245
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 417..545
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 779..898
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 644..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 959 AA; 107050 MW; 036F370E3777DD96 CRC64;
MTAYSKHQPG VVTNRKYIGN PRKKQQFSEH RNLEDSPKED IRFSSLHDLQ SRNKPVCQKC
SETRSLQGVS QPHSLSHSDS ECQLMYRRGS RKHQDAYHKH KHKYCKDPCR PYTKDRSWTA
SPGTVGESDD GLASSETVTA DEQRPAVHKF QEEATKLKSQ SDVRQVLFHM DPRTGTGLAL
VGGNRTGVFV ATVQPDSAAD QSGIGEGDQI RAINELELDG WTKEEVALAL IADDAPIVLS
LKHDPAAYSE VQQSNQSTDF FSVRAYFNLK PDGYTQKNSE GLTELAITEG DIFQVLDTFP
GGVFGNWQAY KIYPSVSVTG IIPNMQRAKG LLEVQTATSS VRAPTPYEKV ILIDSYPLPR
PVVIYGPLSF LARQRLQGLT DSMEPEEKET STRFEVPPVN AHIGQTGPEG YPTGLIRLSA
VKMIMENGAH CLLDINMSAI KRLTFLGIPP IVILICPSSK KQLTMVLQHY WEIDKYSAAL
QYPDLLVKKR SDVLLLSERL WAEVLALKQY RAHLISDSVP VNTENVRGLY FSEVDWIRNL
VSVVQHQQNG PVNYLYCIKR DSGRSRFVSF LFYCWISSDK IHAFSSSVLS VYASCSAEEV
KRFKITRQNG TNVDRQVSAR ALKEEFRSPL KRRTSINRLQ DKRTASYKAT AKATPTGKCS
NHKNSHSSVY KEFLPVEVLS VHGSNSPRTT TPSDVENYNG VVEQISTETH RWLLLDATSQ
NEDFASVQPR GKTDPSKAGI DDISLTSQVL EDTQASPGGA SNRSIISSLP LNTTENILAE
CAGEFGYKGG ALELPEYQVR LHIPKGALPV QCERQRIFLR IYNSHPDCTL GSARATEESS
PRLISPVVMC GPHGLHFRTP VELTVPRYHF DDDNNEESNE NWKITLLHTS AHSTSADEES
VRQEVKLRQN STNWHEIPVI GDLKTSGVRP TEKINGNSDV LGITSLVQDS KIAILIDHF
//
