ID G7YLH8_CLOSI Unreviewed; 946 AA.
AC G7YLH8;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 08-NOV-2023, entry version 47.
DE SubName: Full=Cell division cycle 20-like protein 1 cofactor of APC complex {ECO:0000313|EMBL:GAA53809.1};
GN ORFNames=CLF_111205 {ECO:0000313|EMBL:GAA53809.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA53809.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA53809.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Henan {ECO:0000313|EMBL:GAA53809.1};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the WD repeat CDC20/Fizzy family.
CC {ECO:0000256|ARBA:ARBA00006445}.
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DR EMBL; DF143599; GAA53809.1; -; Genomic_DNA.
DR AlphaFoldDB; G7YLH8; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0010997; F:anaphase-promoting complex binding; IEA:InterPro.
DR GO; GO:0097027; F:ubiquitin-protein transferase activator activity; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR033010; Cdc20/Fizzy.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19918; CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED; 1.
DR PANTHER; PTHR19918:SF1; FIZZY-RELATED PROTEIN HOMOLOG; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR01345; CERVTRCPTASE.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:GAA53809.1};
KW Cell division {ECO:0000313|EMBL:GAA53809.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 506..547
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 507..561
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 726..758
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 859..900
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 309..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 946 AA; 103895 MW; 569AD560852861AA CRC64;
MRLALPVLLS LEHGRLLFAD DLKSWSSNAS AFQMDADAAK QWSLDWHLPL NDEKCVHMSF
GGDSANSFVM HGEKGPEDIT RIDAKRDLGI WLSPNLSFSL HLEKSAQKAF AVLRMIRRTF
SRITRTDFQI LYGAYVRPLL EYANPVVYSG RTKDVILIER VQRAATKMVA GLKSMDYETR
LAVLDLFPLK YRHPRGDLIL TYVLFEQGLA NRFFTVDPAN TRRGHGKVVL DLFPLEYRRL
RGDLILTYAL FEQGLANRFF TVDPANTRRG HDPAATGMRN RCQIAATLTS VAGLSRNWSM
KLFSTGLPPH VDNANGHEQV TSQSNQQSHS AGAESSWRVS ANRTTGTPPG RIPSRDPAIP
AESHVNDLLA ALVANEVADS SMGGSFSPTK PDYISNVGSS SVLAAKENGN MFSYKIRKDN
AAKMKTSPYS MSPVSEKSQS LLKYPQKQTR RISRVPYKVL DAPELQDDFY LNLVDWSSQN
VLAVGLGTCV YLWNAFNSQV TRLCDVSREG DVISSVAWSK KGEHLAIGTY RGHVQIWDVT
KASCLRSLTG HIARVGALAW NADLLASGSR DRYILLRDTR ASATSGGGLS DPVPSAHHPS
SNTVAIPATE MNEQPMLIDG SDPDSPSTPY HVPSMDTDLT DLLGRPDASS SPPNNGTGAT
DLNTTDSDVR TTRATNDLDV SRSLGFSGPR WTGSSNLLGT HTNAGTALQT VENGADRSIS
GAVRVLKDHR QEVCGLKWSP DSQYLASGGN DNRLLVWSQH APASGGPVLT YEEHVAAVKA
IAWSPHQHGL LASGGGTADR CIRFWNTLTG QALRWVDTGS QVCNIAWSVH SNELVSTHGY
SQNQILVWRY PSLTQLVKLT GHSYRVLYLA ISPDGENIVT GAGDETLRFW NIFTKSKTPK
VPVPRLLSSI CSGQDSSQGS PKVIRYTPLR FMAAYVVEYQ ELWFTS
//