ID   G7YPC1_CLOSI            Unreviewed;       747 AA.
AC   G7YPC1;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   28-JUN-2023, entry version 28.
DE   RecName: Full=BRCT domain-containing protein {ECO:0000259|PROSITE:PS50172};
GN   ORFNames=CLF_105467 {ECO:0000313|EMBL:GAA54802.1};
OS   Clonorchis sinensis (Chinese liver fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Opisthorchiida; Opisthorchiata; Opisthorchiidae; Clonorchis.
OX   NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA54802.1, ECO:0000313|Proteomes:UP000008909};
RN   [1] {ECO:0000313|EMBL:GAA54802.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Henan {ECO:0000313|EMBL:GAA54802.1};
RX   PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA   Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA   Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA   Yu X.;
RT   "The draft genome of the carcinogenic human liver fluke Clonorchis
RT   sinensis.";
RL   Genome Biol. 12:R107-R107(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Henan;
RA   Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA   Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA   Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA   Wu Z., Yu X.;
RT   "The genome and transcriptome sequence of Clonorchis sinensis provide
RT   insights into the carcinogenic liver fluke.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DF143925; GAA54802.1; -; Genomic_DNA.
DR   AlphaFoldDB; G7YPC1; -.
DR   Proteomes; UP000008909; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR   CDD; cd17745; BRCT_p53bp1_rpt1; 1.
DR   Gene3D; 3.40.50.10190; BRCT domain; 1.
DR   InterPro; IPR015125; 53-BP1_Tudor.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR047249; BRCT_p53bp1-like_rpt1.
DR   InterPro; IPR047252; TP53BP1-like.
DR   PANTHER; PTHR15321:SF3; TP53-BINDING PROTEIN 1; 1.
DR   PANTHER; PTHR15321; TUMOR SUPPRESSOR P53-BINDING PROTEIN 1; 1.
DR   Pfam; PF09038; 53-BP1_Tudor; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF52113; BRCT domain; 1.
DR   PROSITE; PS50172; BRCT; 1.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008909}.
FT   DOMAIN          426..535
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   REGION          195..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          271..350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        283..308
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..335
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   747 AA;  83064 MW;  6D1CFE918D5F0DBA CRC64;
     MLRTRSLSSR KNWFGCVKID DCESVVVLYE GCKQEERNVP VVNWTFTKRL DLTVLIEVVV
     AAIDEACCFY LAGKIPIYGR WHRQLYYYAG ILELPQPGFR RLVLFEDGSQ SRLKPSDLLY
     VNLLPVSAEV CADWDNNGDF WGDCVVEAHL MDSRRPYLIF CRMNGERKAM ARKDVTIHHS
     QVCRLRDSGL LPVSADAAPE RSGAGSSTKK QPPSKRKTQK PEEQLSQPSG ALLATPEVSL
     TNVLFSKRQP KVKRYRSSWA TPVTRLAAEA KAREGGYSSE GPKHQKLSKS FTMTSSLRSP
     TLGRDSTTSG RCKRLRQRSG RSETTNASGT KKQRLLKSPP HNVLSPLKSN EYDSDVASES
     GRMYLLQNPR FLSLFTIRLF VNNSSIIVSD RFTKQPSNLM LGNFSLLTQK LRQAKSLSRC
     LGIPVPSARL FYGWKIMITG RVTVLNAPGQ GGRNILEQLV VACGGEIITQ IVPFLRSRPD
     AGDSPILGSD VHSSSSQSTT NVALVAPECC RTLKYFQALA TLGRIPLLHT DWILDACREE
     AVAFADENMQ PGVSLDWPMR LLLSCPGRYE LPRGISSVDG ERISWFAVPI RYRFPAYQAL
     PPLSLFDLRV DWLGSQNKCE LVAIVTDDME VFGPAWANIL QLANGAPLSS DELGSHVVKP
     IPIVSTDEAP QKLRHLLYPV RSRPTPQRSV NKGSLVLIDV ADLSSECIAE LDVLPCQLVT
     CDYFIQSLIC GHLLNPADSS AFVPPRH
//